1.
J Virol
; 85(19): 10404-8, 2011 Oct.
Article
in English
| MEDLINE
| ID: mdl-21795336
ABSTRACT
Candid1, a live-attenuated Junin virus vaccine strain, was developed during the early 1980s to control Argentine hemorrhagic fever, a severe and frequently fatal human disease. Six amino acid substitutions were found to be unique to this vaccine strain, and their role in virulence attenuation in mice was analyzed using a series of recombinant viruses. Our results indicate that Candid1 is attenuated in mice through a single amino acid substitution in the transmembrane domain of the G2 glycoprotein. This work provides insight into the molecular mechanisms of attenuation of the only arenavirus vaccine currently available.
Subject(s)
Junin virus/immunology , Junin virus/pathogenicity , Mutation, Missense , Viral Envelope Proteins/genetics , Viral Vaccines/genetics , Virulence Factors/genetics , Amino Acid Substitution/genetics , Animals , Arenaviridae Infections/pathology , Arenaviridae Infections/virology , DNA Mutational Analysis , Disease Models, Animal , Mice , Molecular Sequence Data , Point Mutation , Rodent Diseases/pathology , Rodent Diseases/virology , Sequence Analysis, DNA , Vaccines, Attenuated/genetics , Vaccines, Attenuated/immunology , Viral Envelope Proteins/metabolism , Viral Vaccines/immunology , Virulence Factors/metabolism
2.
Buenos Aires; Vitae; ago. 1960. 156 p. (67709).
Monography
in Spanish
| BINACIS
| ID: bin-67709
3.
Buenos Aires; Vitae; ago. 1960. 156 p.
Monography
in Spanish
| BINACIS
| ID: biblio-1194078
4.
Boletín de la Oficina Sanitaria Panamericana (OSP)
; 39(6),dic. 1955
Article
| PAHO-IRIS
| ID: phr-12112