Subject(s)
Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/therapy , Intestinal Mucosa/metabolism , Nitro Compounds/therapeutic use , Adsorption , Adult , Diabetes Mellitus, Type 1/metabolism , Diabetes Mellitus, Type 2/metabolism , Female , Humans , Intestines/drug effects , Male , Middle Aged , Nitro Compounds/pharmacokineticsSubject(s)
Alcoholism/complications , Endocrine System Diseases/etiology , Animals , Female , Humans , RatsSubject(s)
Coronary Disease/complications , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Fatty Acids/blood , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Sixty-six patients with diabetes mellitus were treated with carbon-containing sorbents with a resultant decrease in the content of cholesterol in lipoproteins of antiatherogenic classes and an increase in high-density lipoproteins (HDL), glycosylation of lipoproteins was suppressed, detoxicating and synthetic liver function was improved.
Subject(s)
Arteriosclerosis/prevention & control , Charcoal/therapeutic use , Diabetes Complications , Adolescent , Adult , Aged , Arteriosclerosis/etiology , Cholesterol/blood , Diabetes Mellitus/drug therapy , Female , Humans , Lipoproteins/blood , Lipoproteins, HDL/blood , Male , Middle AgedABSTRACT
The internal use of carbon containing sorbents (enterosorption) in the treatment of patients with diabetes mellitus accelerates metabolic compensation and helps to decrease a dose of sugar reducing agents. The antiatherogenic mechanisms are activated, expressed in a decrease in the level of total cholesterol, triglycerides, lipids, the atherogenicity index and an increase in cholesterol in high density lipoproteins. The use of enterosorbents in the treatment of patients with disturbed cardiac rhythm reduces the time of treatment and eliminates the side-effects of antiarrhythmic drugs.
Subject(s)
Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/therapy , Adult , Charcoal/therapeutic use , Chronic Disease , Evaluation Studies as Topic , Female , Humans , Intestinal Absorption , Male , Methods , Middle AgedSubject(s)
Coronary Disease/blood , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Lipoproteins/blood , Adult , Aged , Blood Glucose/analysis , Coronary Disease/complications , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Glycated Hemoglobin/analysis , Glycation End Products, Advanced , Humans , Lipoproteins, HDL/blood , Lipoproteins, LDL/blood , Middle AgedSubject(s)
Diabetes Mellitus, Type 1/drug therapy , Diabetes Mellitus, Type 2/drug therapy , Erythrocyte Membrane/metabolism , Lipid Peroxides/blood , Adult , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Free Radicals , Humans , Insulin/therapeutic use , Middle Aged , Sulfonylurea Compounds/therapeutic useSubject(s)
Autoimmune Diseases/etiology , Endocrine System Diseases/etiology , Adrenal Cortex/pathology , Adrenal Insufficiency/diagnosis , Atrophy , Autoantibodies/analysis , Autoimmune Diseases/diagnosis , Autoimmune Diseases/immunology , Endocrine System Diseases/diagnosis , Endocrine System Diseases/immunology , Genes , Humans , Immunity, Cellular , Major Histocompatibility Complex , SyndromeABSTRACT
A decrease in the concentration of high density cholesterol lipoproteins (HDCSLP) and an increase in the atherogeny index were observed in patients with diabetes mellitus, regardless the sex and age. The blood HDCSLP content is lower in males, suffering from the II and III stage ischemic heart disease, aggravated by diabetes mellitus comparatively to that of the females. Diabetes mellitus compensation promotes HDCSLP rising, nevertheless not acquiring the control level.
Subject(s)
Cholesterol/blood , Coronary Disease/etiology , Diabetic Angiopathies/etiology , Lipoproteins, HDL/blood , Adult , Aged , Aging , Angina Pectoris/blood , Angina Pectoris/etiology , Cholesterol, HDL , Coronary Disease/blood , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Diabetic Angiopathies/blood , Female , Humans , Male , Middle Aged , Sex CharacteristicsABSTRACT
In patients with diabetes mellitus, the processes of lipid peroxidation are activated and the system of antioxidants is disturbed (the content of reduced glutathione and red cell glutathione reductase is lowered and red cell glutathione peroxidase activity is heightened). At the same time the patients demonstrate high concentration of sterols bound by fibrinogen, a considerable lowering of cholesterol content in high density lipoproteins having an antiiatrogenic action. The alterations found underlie the development of atherosclerosis and coronary heart disease.