[Effect of manganese on transketolase activity and total pentose content in rabbits]. / Vliianie margantsa na transketolaznuiu aktivnost' i soderzhanie obshchikh pentoz v organizme krolikov.

Different doses of manganese are shown to exert a positive effect on the transketolase activity in the blood serum and in certain tissues as well as on the amount of total pentoses in the blood serum of rabbits. This confirms intensification of the pentose-phosphate exchange of carbohydrates under the effect of manganese.

[Effect of combined administration of manganese and insulin on glucose utilization]. / Vliianie sovmestnogo vvedeniia margantsa i gliukozy na utilizatsiiu gliukozy.

A prolonged action of exogenic insulin is found in rabbits with preliminary manganese injection. Under conditions of experimental hyperglycemia the mentioned trace element injected in combination with insulin into the test animal organism causes a gradual decrease in the glucose level in the blood as compared with the only insulin injections. A possibility of a prolonged action of the hormone is very important for insulin therapy.

[Effect of manganese on the sugar content, hexokinase and insulin activity of rabbit blood]. / Vliianie margantsa na soderzhanie sakhara, geksokinaznuiu i insulinovuiu aktivnost' v krovi krolikov.

The paper deals with the effect of manganese on the sugar content and the hexokinase and insulin activity in the rabbit blood. The trace element in a dose of 0.1-3.0 mg/kg has a definite hypoglycemic effect. The sugar level lowers significantly during the whole period of the experiment with administration of 0.6 and 3.0 mg/kg of manganese; the activity of hexokinase and insulin being significantly increased. It is supposed that a change in the enzyme and insulin activity under the effect of manganese is one of the reasons of the sugar level decrease in the blood.

[Influence of manganese on the level of glycogen and its fractions in organism tissues]. / Vliianie margantsa na uroven' glikogena i ego fraktsii v tkaniakh organizma.

Changes in the level of total glycogen and its fractions in the organism tissues were studied under conditions of injecting different doses of manganese into intact rabbits. It is established that the trace element doses of 0.6 and 3 mg per 1 kg of the weight cause a significant increase in the total glycogen quantity in the liver, mainly due to its free and protein-bound forms. Higher doses of manganese (6 mg/kg) produce an opposite effect. In the cerebral tissues the level increase of total glycogen and in most cases of its fractions occurs under the influence of the trace element in doses of 0.1-6 mg/kg. In the myocardium tissue manganese did not cause any significant changes in the glycogen level. It is supposed that manganese participates in the processes of glycogene metabolism in the organism.

[Interrelationship between manganese, vitamin B1 and the level of pyruvic acid]. / Izuchenie vzaimosviazi mezhdu margantsem, vitaminom B1 i urovnem pirovinogradnoi kisloty.

Addition of manganese to the diets promotes an increase of the total thiamine content in the blood and the liver, heart and brain tissues. This trace element appreciably changes the correlation between different thiamine fractions. The free vitamin B1 level in the blood and tissues decreases, while the level of its bound form (pyrophosphatic) increases. All the administered manganese doses induced a statistically significant reduction of pyruvic acid concentration in the blood.