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Resistant Kawasaki disease treated with anti-CD20.
Sauvaget, Emilie; Bonello, Béatrice; David, Marion; Chabrol, Brigitte; Dubus, Jean-Christophe; Bosdure, Emmanuelle.
J Pediatr ; 160(5): 875-6, 2012 May.
Article in English | MEDLINE | ID: mdl-22341587

ABSTRACT

We report the case of a 6-year-old boy who had Kawasaki disease resistant to intravenous immunoglobulin and systemic steroids. Because of an uncontrolled disease course, with significant lesions of the coronary arteries, anti-CD20 treatment was used. Rapid clinical, biological, and cardiac improvement was observed. The patient tolerated the treatment well.


Subject(s)
Antibodies, Monoclonal, Murine-Derived/administration & dosage , Immunologic Factors/administration & dosage , Mucocutaneous Lymph Node Syndrome/drug therapy , Blood Chemical Analysis , Child , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Resistance , Echocardiography, Doppler , Follow-Up Studies , Humans , Immunoglobulins, Intravenous/therapeutic use , Male , Mucocutaneous Lymph Node Syndrome/diagnosis , Risk Assessment , Rituximab , Severity of Illness Index , Treatment Outcome
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