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Invasive aspergillosis with pulmonary and central nervous system involvement during ibrutinib therapy for relapsed chronic lymphocytic leukaemia: case report.

Peri, A M; Bisi, L; Cappelletti, A; Colella, E; Verga, L; Borella, C; Foresti, S; Migliorino, G M; Gori, A; Bandera, A.

Clin Microbiol Infect ; 24(7): 785-786, 2018 07.

Article in English | MEDLINE | ID: mdl-29427802

Subject(s)

Central Nervous System Fungal Infections/diagnosis , Central Nervous System Fungal Infections/etiology , Invasive Pulmonary Aspergillosis/diagnosis , Invasive Pulmonary Aspergillosis/etiology , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Pyrazoles/adverse effects , Pyrimidines/adverse effects , Adenine/analogs & derivatives , Antifungal Agents/pharmacology , Antifungal Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Blood Culture/methods , Central Nervous System Fungal Infections/drug therapy , Humans , Invasive Pulmonary Aspergillosis/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Neoplasm Recurrence, Local , Piperidines , Pyrazoles/administration & dosage , Pyrazoles/therapeutic use , Pyrimidines/administration & dosage , Pyrimidines/therapeutic use , Tomography, X-Ray Computed , Treatment Outcome

Synthesis and structure-activity relationships of new second-generation taxoids.

Ojima, I; Wang, T; Miller, M L; Lin, S; Borella, C P; Geng, X; Pera, P; Bernacki, R J.

Bioorg Med Chem Lett ; 9(24): 3423-8, 1999 Dec 20.

Article in English | MEDLINE | ID: mdl-10617084

ABSTRACT

A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as "advanced second generation taxoids".

Subject(s)

Alkaloids/chemical synthesis , Antineoplastic Agents/chemical synthesis , Alkaloids/chemistry , Alkaloids/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Drug Screening Assays, Antitumor , Humans , Paclitaxel/analogs & derivatives , Structure-Activity Relationship , Tumor Cells, Cultured

[Rhabdomyolysis complicating acute lumbar compartment syndrome]. / Rhabdomyolyse compliquant un syndrome compartimental lombaire aigu.

Leone, J; Hamon, R; Borella, C; Detree, F; Pennaforte, J L; Eschard, J P; Etienne, J C.

Rev Rhum Ed Fr ; 61(11): 865-7, 1994 Dec.

Article in French | MEDLINE | ID: mdl-7858586

Subject(s)

Compartment Syndromes/complications , Rhabdomyolysis/etiology , Acute Disease , Adult , Humans , Lumbar Vertebrae , Male

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