1.
Bioorg Med Chem Lett
; 28(17): 2985-2992, 2018 09 15.
Article
in English
| MEDLINE
| ID: mdl-30122227
ABSTRACT
A series of squaramide-based hydroxamic acids were designed, synthesized and evaluated against human HDAC enzyme. Squaramides were found to be potent in the Hut78 cell line, but initially suffered from low solubility. Leads with improved solubility and metabolic profiles were shown to be class I, IIB and IV selective.