Subject(s)
Glaucoma/diagnosis , Glaucoma/etiology , Weill-Marchesani Syndrome/complications , Weill-Marchesani Syndrome/diagnosis , Adolescent , Ectopia Lentis/complications , Ectopia Lentis/diagnosis , Ectopia Lentis/pathology , Female , Glaucoma/pathology , Humans , Lens, Crystalline/diagnostic imaging , Lens, Crystalline/pathology , Weill-Marchesani Syndrome/pathologySubject(s)
Papilledema/complications , Papilledema/diagnosis , Tuberous Sclerosis/complications , Adolescent , Angiofibroma/complications , Angiofibroma/diagnosis , Facial Neoplasms/complications , Facial Neoplasms/diagnosis , Fluorescein Angiography , Hamartoma/complications , Hamartoma/diagnosis , Humans , Male , Retinal Diseases/complications , Retinal Diseases/diagnosis , Skin Neoplasms/complications , Skin Neoplasms/diagnosis , Tuberous Sclerosis/diagnosisABSTRACT
PURPOSE: To determine whether phacoemulsification with intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients compared to non-diabetic patients. MATERIALS AND METHODS: This study compared the endothelial status in 32 diabetics with good glycemic control and 32 non-diabetic patients before and after uneventful phacoemulsification. Central corneal thickness (CCT), central corneal endothelial cell density (CD), hexagonal cell percentage (HEX), and percent coefficient of variation (% CV) were measured using a specular microscope. RESULTS: Data were matched by age and sex. Diabetics showed a significantly higher loss of endothelial cells compared to non-diabetics. After 3 months, there was a decline of 165 endothelial cells (SD 97) in the diabetic group and 114 (SD 45) in the control group. This was statistically significant (P=0.0065). In addition, diabetics showed a slower recovery trend of endothelial healing as evidenced by a lower CV variation. The CV change was 4.7 in the control group and 3.2 in the diabetic group, which was statistically significant (P=0.023). A significant correlation was found between the energy used and the change in endothelial count as well as the CV in both groups. CONCLUSION: Despite good glycemic control, diabetics have significantly more endothelial damage compared to non-diabetics with a similar nuclear classification and phacoemulsification energy used. This justifies a more careful use of phacoemulsification energy in diabetics.