Are the screening guidelines for branch duct intraductal papillary mucinous neoplasms cost-effective in an Australian setting?

BACKGROUNDS: Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms of the pancreatic ductal system. These incidental cystic lesions are increasingly found on radiological imaging and screened for malignant transformation. The Fukuoka consensus guidelines recommend screening with computed tomography, magnetic resonance imaging or endoscopic ultrasound. Branch duct IPMN (BD-IPMN) have significantly lower malignancy and mortality rates compared to main duct IPMN. Our aim was to assess the cost-effectiveness of guideline's recommendations for BD-IPMN screening of cysts between 2 and 3 cm in an Australian context. METHODS: Markov model decision analysis was used to calculate the incremental cost-effectiveness ratio (ICER) of screening. The ICER was compared to a willingness to pay (WTP) threshold of $50 000. We performed scenario analysis to examine the effect of cyst size and non-linearity of malignancy rate on ICER. Probabilistic sensitivity analyses (PSA) were performed on our input parameters. RESULTS: Screening resulted in 586 quality adjusted life years gained and a net present value of $20 379 939, resulting in a base-case ICER of $34 758. After scenario analysis for non-linearity of malignancy rate the ICER increases to $64 555, which is above the WTP threshold. PSA indicates that ICER is most susceptible to the pre-test malignancy rate. CONCLUSION: This cost analysis demonstrates that screening of 2-3 cm BD-IPMN according to current guidelines is unlikely to be cost-effective in an Australian context. To determine the true ICER, a cost analysis on real-world data is required.

Audit of cervical excision depth of large loop excision of the transformation zone procedures at Counties Manukau District Health Board.

AIMS: Cervical cancer is the fourth most common malignancy in females worldwide. Large loop excision of the transformation zone (LLETZ) procedures remain the preferred surgical technique to remove squamous cervical intraepithelial neoplasia (CIN) lesions globally. This study aimed to assess whether the depth of LLETZ procedures at Counties Manukau District Health Board (CMDHB) met established standards of care. METHODS: Hospital records were reviewed for all LLETZ procedures performed at CMDHB between 1 June 2020 to 3 May 2021, and these were compared to Public Health England's (PHE) 2020 Colposcopy Guidelines. RESULTS: One hundred and eighty-four cases were identified. Forty-eight percent of all LLETZ procedures were the correct excision depth relative to PHE's ≥95% threshold, primarily due to excisions being too shallow, particularly in patients with type 2 and 3 transformation zones (TZ), 48% and 86%, respectively. Maori and Pasifika patients represented only 16% and 13% of all LLETZ procedures in this study, respectively. CONCLUSIONS: This study identified significant oversampling of LLETZ excisions in patients with type 1 TZs, and significant under-sampling in patients with types 2 and 3 TZs. Ultimately, these findings highlight the need for additional quality improvement processes and emphasise the importance of auditing LLETZ procedures nationwide.

The architecture of the 6-month-old gastrocnemius: a 3D volumetric study

Gastrocnemius is essential in normal gait, contributing to the control of ankle plantar flexion and knee flexion. However, there is a paucity of literature on the architecture of the infant gastrocnemius muscle prior to the onset of weight-bearing and gait. This study investigates the three-dimensional (3D) musculoaponeurotic architecture of the gastrocnemius in a six-month-old infant. One six-month-old cadaver was used in this study (The University of Toronto Health Sciences Research Ethics Board, #32679, and The University of Auckland Human Participants Ethics Committee, #016164). Medial (MG) and lateral (LG) heads of the gastrocnemius were serially dissected and a Microscribe G2X(TM) digitizer used to digitize fiber bundles, aponeuroses and tendons. Data were then exported to Autodesk(R) Maya(R) to create 3D models. Custom software quantified architectural parameters, including fiber bundle length, pennation angle, physiological cross-sectional area, and muscle volume. The intramuscular architecture was assessed to determine whether musculoapo-neurotic partitions were present. Muscle volume was <1cm3 for both MG and LG. Three architectural partitions, proximal, middle, and distal, were identified for both MG and LG. Notably, the proximal partitions of both MG and LG had mean fiber bundle length at 2.21 ± 0.41 cm and 2.22 ± 0.27 cm, significantly greater (p < 0.05) than the middle and the distal partitions. The results of this study suggest that both MG and LG have architectural partitions before the commencement of gait. Further longitudinal studies with larger sample sizes are needed to confirm the presence of these architectural partitions, as well as to investigate their growth across the developmental spectrum

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The incidence of symptomatic remnant gall bladder: a population study.

BACKGROUND: Subtotal cholecystectomy is utilized in conditions of high risk to critical structures, like the common bile duct. However, the remnant gall bladder may become symptomatic and require a completion cholecystectomy for treatment. This second procedure can itself be a risk to critical structures. To establish the incidence of redo-cholecystectomy and identify risk factors that lead to subtotal cholecystectomy and repeat operation in a review of state-based practices for cholecystectomy. METHODS: A search of state coding records relating to cholecystectomy from 1998 to 2016. Patients who were coded for cholecystectomy-related procedures on different dates were identified. Patients who underwent the procedures within 6 months were excluded to avoid acute post-operative complications and gall bladder malignancy. RESULTS: 210 719 cholecystectomies were performed. 1133 required repeat procedure. 616 were excluded, leaving 516 (0.25%) cholecystectomy patients requiring a second cholecystectomy. The subsequent operation was more likely to be an emergency procedure; involve transcystic bile duct exploration, adhesiolysis and require intensive care unit admission post-operatively. A repeat cholecystectomy was more likely to occur after having the primary procedure at a public hospital and when an intra-operative cholangiogram was not performed. Over the study period, the rate of repeat cholecystectomy increased from 0.02% to 0.6%. Incidentally, the rate of intra-operative cholangiogram during a primary cholecystectomy increased from 43% to 73%. CONCLUSIONS: Repeat cholecystectomy is an uncommon procedure. A second cholecystectomy is a more complex and likely to require intensive care unit support. Referral to a tertiary hepatobiliary unit is recommended.

Outcomes of central hepatectomy versus extended hepatectomy.

BACKGROUND: Central hepatectomy (CH) is more difficult than extended hepatectomy (EH) and is associated with greater morbidity. In this modern era of liver management with aims to prevent post-hepatectomy liver failure (PHLF), there is a need to assess outcomes of CH as a parenchyma-sparing procedure for centrally located liver tumors. METHODS: A total of 178 major liver resections performed by specialist surgeons from two Australian tertiary institutions between June 2009 and March 2017 were reviewed. Eleven patients had CH and 24 had EH over this study period. Indications and perioperative outcomes were compared between the groups. RESULTS: The main indication for performing CH was colorectal liver metastases. There was no perioperative mortality in the CH group and four (16.7%) in the EH group (P = 0.285). No group differences were found in median operative time [CH vs. EH: 450 min (290-840) vs. 523 min (310-860), P = 0.328], intraoperative blood loss [850 mL (400-1500) vs. 650 mL (100-2000), P = 0.746] or patients requiring intraoperative blood transfusion [1 (9.1%) vs. 7 (30.4%), P = 0.227]. There was a trend towards fewer hepatectomy-specific complications in the CH group [3 (27.3%) vs. 13 (54.2%), P = 0.167], including PHLF (CH vs. EH: 0 vs. 29.2%, P = 0.072). Median length of stay was similar between groups [CH vs. EH: 9 days (5-23) vs. 12 days (4-85), P = 0.244]. CONCLUSIONS: CH has equivalent postoperative outcomes to EH. There is a trend towards fewer hepatectomy-specific complications, including PHLF. In appropriate patients, CH may be considered as a safe parenchyma-sparing alternative to EH.

Is operative management of fractures safe in the collocated burn and fracture injury?

AIMS: To review the management of a collocated major fracture and dermal burn injury in adult multi-trauma patients. In particular, this study examines the methods and timing for fracture fixation and the fracture complications observed. METHODS: A retrospective chart review of all patients admitted to the Alfred Hospital, Melbourne, Australia from January 2000 to December 2012 with a collocated dermal burn and major fracture. RESULTS: Of the 22 patients included (median abbreviated injury score-98 of 22 and total burn surface area of 8%), 17 underwent operative fracture fixation. Eleven patients had internal fixation, two had external fixation and four had temporary external fixation with delayed internal fixation. Median time to operative fixation was 5.7h (interquartile range: 3.5-16.8), with 15 of the 17 patients undergoing fixation within 24h. Nine patients experienced a fracture complication. Five patients had an infective fracture complication (wound infection or osteomyelitis), and all of these patients had had internal fixation. No fracture complications occurred in patients managed conservatively. CONCLUSION: Previous studies have supported the use of internal fixation for early mobility and simplified wound care. However, we observed a high rate of fracture complications with internal fixation, despite undergoing management within 24h of presentation. At this point, we are unable to conclude on the safety of utilising internal fixation in the collocated injury.

Implementation of the Canadian C-spine rule reduces cervical spine x-ray rate for alert patients with potential neck injury.

The objectives of this before-and-after study of alert, stable adult patients presenting to the Emergency Department of Western Hospital with potential neck injuries who were immobilized in hard cervical collars were to determine the impact of implementation of the Canadian C-spine rule on x-ray ordering rates and whether implementation of the rule reduced time in hard collars for patients with potential neck injury. Data collected included demographics, mechanism of injury, x-ray rate, and time in hard collar. Data analysis was by chi-square test for proportions and Mann-Whitney U test for continuous variables. There were 211 patients studied. The x-ray ordering rate decreased from 67% to 50% (25% relative reduction, p = 0.0187). Time in hard collar was also reduced from a median of 128 min to a median of 103 min (effect size 25.5 min), but this did not reach statistical significance. Implementation of the Canadian C-spine rule reduced x-ray ordering by 25%.

Can nurses apply the Canadian C-Spine Rule? A pilot study.

OBJECTIVE: The aim of this study was to determine the inter-rater agreement between physicians and nurses regarding eligibility for application of the Canadian C-Spine Rule (CCR) and assessment of the criteria of the CCR. METHODS: In this observational study, nurses and physicians independently assessed the CCR criteria in a convenience sample of patients with potential C-spine injury. Data were entered onto separate data sheets. The outcomes of interest were the inter-rater agreement between nurse and physician regarding eligibility for application of the rule, for assessment of each component of the rule and for interpretation of the rule overall, assessed by kappa analysis. RESULTS: In total, 88 cases were eligible for analysis. Physicians and nurses agreed on which patients were eligible for CCR application in 96.6% of cases. Inter-rater agreement for most CCR criteria was good (* > 0.61), with the exception of midline tenderness (* = 0.58) and range of motion, which most nurses did not test. CONCLUSION: This study shows that nurses have the potential to reliably apply the Canadian C-Spine Rule but require further training in the assessment of midline tenderness and range of motion.