Subject(s)
Lung , Ultrasonography, Doppler, Color , Ultrasonography, Prenatal , Humans , Female , Ultrasonography, Doppler, Color/methods , Pregnancy , Ultrasonography, Prenatal/methods , Lung/diagnostic imaging , Lung/abnormalities , Lung/embryology , Adult , Airway Obstruction/diagnostic imaging , Airway Obstruction/congenital , Airway Obstruction/etiology , Bronchial Diseases/diagnostic imaging , Bronchial Diseases/congenitalSubject(s)
Myofibromatosis , Diagnosis, Differential , Diagnostic Imaging , Female , Humans , Myofibromatosis/diagnostic imaging , PregnancyABSTRACT
The good knowledge of the characteristics of the left outflow tract allows us to detect but also to identify anomalies such as conal VSD and conotruncal anomalies. The analysis of this specific area of the heart must always be performed as part of a global analysis of the outflow tracts, combining the analysis of the right outflow tract with the assessment of the three vessel and trachea view.
Subject(s)
Heart Defects, Congenital/diagnosis , Heart Ventricles/abnormalities , Echocardiography , Female , Heart Defects, Congenital/diagnostic imaging , Heart Ventricles/diagnostic imaging , Heart Ventricles/physiopathology , Humans , Pregnancy , Stroke Volume , Ultrasonography, PrenatalABSTRACT
OBJECTIVES: To assess the added value of intravenous gadolinium injection to magnetic resonance imaging (MRI) -based diagnosis of abnormally invasive placenta (AIP) and to examine this in relation to the radiologist's experience. DESIGN: Retrospective study. SETTING: Between March 2009 and October 2012, 31 pregnant women who had previous caesarean delivery together with a placenta praevia and suspected placenta accreta on ultrasound in the third trimester of pregnancy. POPULATION: All were offered MRI examination, and made aware of the limited (but so far reassuring) data regarding fetal safety of gadolinium. Twenty pregnant women agreed to undergo prenatal MRI (1.5 T), with and without gadolinium injection. METHODS: Two sets of MRI examinations without and with gadolinium were reviewed independently 2 months apart by two senior and two junior radiologists; all were blinded to the outcome (known in all cases). Histopathological findings and clinical signs of AIP were considered as the defining criteria of diagnosis. MAIN OUTCOME MEASURE: accuracy of MRI with and without gadolinium was assessed. RESULTS: Eight of the 20 women had confirmed abnormal placental invasion. The overall performance of both sets of readers in detecting AIP increased with gadolinium-sensitivity and specificity of 75.0% (42.0-100%) and 47.9% (19.9-75.9%) increasing to 87.5% (57.1-100%) and 60.4% (33.9-86.9%), respectively (P = 0.04). The added value of gadolinium remained irrespective of radiologist's experience, although senior radiologists performed better overall (sensitivity and specificity of 87.5% and 62.5% versus 62.5% and 33.3%, respectively, increasing with injection to 93.8% and 70.8% versus 81.3% and 50%, respectively; P < 10-4 ). CONCLUSION: There was an association between gadolinium use and improvement in MRI-based diagnostic accuracy for the diagnosis of AIP, for both junior and senior radiologists. TWEETABLE ABSTRACT: Gadolinium injection improves MRI performance of radiologists for the diagnosis of placenta accreta.
Subject(s)
Gadolinium , Magnetic Resonance Imaging/methods , Placenta Accreta/diagnosis , Placenta Previa/diagnosis , Placenta/pathology , Administration, Intravenous , Adult , Contrast Media , Female , Humans , Predictive Value of Tests , Pregnancy , Pregnancy, High-Risk , Retrospective Studies , Sensitivity and Specificity , Ultrasonography, Prenatal/methodsABSTRACT
The management of patients with congenital heart disease was profoundly changed firstly by the advent of pediatric and prenatal ultrasound and then more recently by cardiac magnetic resonance imaging (MRI) and computed tomography (CT) of the heart and great vessels. The improved life expectancy of these patients has brought about new medical and imaging requirements. MRI and CT are increasing second line techniques in this group of patients. This article summarizes the advantages and limitations of CT and MRI in some frequently encountered situations in children and adults followed up for congenital heart disease.
Subject(s)
Cardiac Imaging Techniques/trends , Heart Defects, Congenital/diagnostic imaging , Heart Defects, Congenital/surgery , Magnetic Resonance Imaging/trends , Tomography, X-Ray Computed/trends , Adult , Child , Forecasting , Humans , Image Interpretation, Computer-Assisted/methods , Imaging, Three-Dimensional/methods , Imaging, Three-Dimensional/trends , Sensitivity and SpecificityABSTRACT
If ultrasonography is the first intention exam in the evaluation of fetal cerebral structures, MR is the second intention exam the indications of which are well defined. Both techniques are complementary but still independent and the retrospective synthesis of these exams allows optimal analysis of fetal cerebral anomalies. Real time virtual sonography can synchronize a sonographic image and MRI multiplanar image of the same section in real time. This technique can be performed in the evaluation of fetal cerebral structures and synchronous recognition of anatomic structures and has many advantages especially on the pedagogic plan. However, this technique is currently limited to the research area.
Subject(s)
Brain/embryology , Magnetic Resonance Imaging/methods , Ultrasonography, Prenatal/methods , Echoencephalography/methods , Female , Humans , PregnancyABSTRACT
OBJECTIVES: Perinatal asphyxia complicated by hypoxic ischemic brain injury remains a source of neurological lesions. A major aim of neonatologists is to evaluate the severity of neonatal encephalopathy (NE) and to evaluate prognosis. The purpose of this study was to determine the contribution of brain MRI compared to electroencephalogram (EEG) and clinical data in assessing patients' prognosis. MATERIALS AND METHODS: Thirty newborns from the pediatric resuscitation unit at Rouen university hospital were enrolled in a retrospective study between January 2006 and December 2008, prior to introduction of hypothermia treatment. All 30 newborns had at least two anamnestic criteria of perinatal asphyxia, one brain MRI in the first 5 days of life and another after 7 days of life as well as an early EEG in the first 2 days of life. Then, the infants were seen in consultation to assess neurodevelopment. RESULTS: This study showed a relation between NE stage and prognosis. During stage 1, prognosis was good, whereas stage 3 was associated with poor neurodevelopment outcome. Normal clinical examination before the 8th day of life was a good prognostic factor in this study. There was a relationship between severity of EEG after the 5th day of life and poor outcome. During stage 2, EEG patterns varied in severity, and brain MRI provided a better prognosis. Lesions of the basal ganglia and a decreased or absent signal of the posterior limb of the internal capsule were poor prognostic factors during brain MRI. These lesions were underestimated during standard MRI in the first days of life but were visible with diffusion sequences. Cognitive impairment affected 40% of surviving children, justifying extended pediatric follow-up. CONCLUSION: This study confirms the usefulness of brain MRI as a diagnostic tool in hypoxic ischemic encephalopathy in association with clinical data and EEG tracings.
Subject(s)
Asphyxia Neonatorum/diagnosis , Asphyxia Neonatorum/therapy , Brain Damage, Chronic/therapy , Brain/pathology , Electroencephalography , Hypothermia, Induced , Hypoxia-Ischemia, Brain/therapy , Magnetic Resonance Imaging , Neurologic Examination , Apgar Score , Asphyxia Neonatorum/classification , Brain Damage, Chronic/classification , Brain Damage, Chronic/diagnosis , Child, Preschool , Cohort Studies , Developmental Disabilities/classification , Developmental Disabilities/diagnosis , Developmental Disabilities/therapy , Female , Fetal Distress/classification , Fetal Distress/diagnosis , Fetal Distress/therapy , Follow-Up Studies , France , Humans , Hypoxia-Ischemia, Brain/classification , Hypoxia-Ischemia, Brain/diagnosis , Infant , Infant, Newborn , Male , PrognosisABSTRACT
Walker-Warburg syndrome (WWS) is a rare, lethal autosomal recessive disorder characterized by congenital muscular dystrophy and brain and eye anomalies. A prenatal finding of hydrocephalus associated with posterior fossa anomalies and/or encephalocele is nonspecific, whereas additional ocular anomalies are typical for WWS. We report a fetus of consanguineous parents found to have encephalocele at US in week 15 of gestation. The parents did not wish to terminate the pregnancy. Follow-up US revealed bilateral abnormal ocular echoic structures suggesting a major form of persistent primary vitreous. WWS was suspected. The POMT2 mutation confirmed this diagnosis. In hydrocephalus associated with posterior fossa anomalies and/or encephalocele, we recommend detailed US examination of the fetal eyes. Ocular anomalies in this context strongly suggest WWS.
Subject(s)
Retinal Detachment/congenital , Retinal Detachment/diagnostic imaging , Ultrasonography, Prenatal/methods , Walker-Warburg Syndrome/diagnostic imaging , Walker-Warburg Syndrome/embryology , HumansSubject(s)
Gastroschisis/complications , Gastroschisis/diagnostic imaging , Septum Pellucidum/abnormalities , Abortion, Eugenic , Adolescent , Adult , Female , Gastroschisis/surgery , Humans , Incidental Findings , Infant, Newborn , Infant, Newborn, Diseases/surgery , Pregnancy , Ultrasonography, Prenatal , Young AdultABSTRACT
PURPOSE: Perinatal stroke is the most frequent cause of congenital hemiplegia. The MR imaging features of cerebral infarction in full-term newborns will be reviewed and the underlying etiologies discussed. PATIENTS AND METHODS: Retrospective study (1999-2005) including 15 newborn infants without history of fetal distress with early seizures (before day 7) with ischemic or hemorrhagic infarct on MR. All MR examinations were reviewed by consensus (MBD, CHA) using a checklist and results were correlated with findings at clinical follow-up (mean follow-up of 1 year). RESULTS: MR showed ischemic strokes in 10 infants (5 left, 4 right, 1 bilateral) in the middle (n=9) or anterior (n=1) cerebral artery distribution or with extensive bilateral distribution. The cortex and subcortical regions were involved in all cases with ipsilateral basal ganglia/internal capsule extension in 4 cases. The imaging features were related to the timing of the MR examination: within 5 days (n=4): cortical effacement on T1W and T2W images, increased signal on DWI with reduced signal on ADC; between 7-14 days (n=6): T1W hyperintense and T2W hypointense cortex. Five infants had unifocal (3/5) or multifocal (2/5) hemorrhagic infacrtion. Of 13 patients followed-up from 3 months to 3 years (1 lost to follow-up, 1 deceased), 11 had no clinical deficits, 1 had hemiparesis, and 1 had asymmetrical muscle tone. The latter 2 infants had involvement of the posterior limb internal capsule, with basal ganglia and hemispheric involvement. In the literature, this association of lesions is considered predictive of hemiplegia and a high rate of sequelae is reported following neonatal stroke: 50-75% with motor deficit and/or seizure disorder. The 4 infacts with hemorrhagic infarction followed-up for 14 months to 5 years had a globally favorable neurological outcome. CONCLUSION: Cerebral infacrtion in full-term newborns without associated risk factor is variable and should be recognized. Early MR, before day 2, with diffusion-weighted sequences, allows diagnosis but follow-up MR after day 7 is necessary to better depict the extent of permanent lesions. The presence of hemorrhage is not a predictive factor of poor neurological outcome.
Subject(s)
Cerebral Infarction/diagnosis , Magnetic Resonance Imaging , Female , Humans , Infant, Newborn , Male , Retrospective StudiesABSTRACT
Although prenatal sonography remains the primary imaging method for screening fetal anomalies, fetal MRI with ultrafast imaging technique is a complementary imaging method as soon as the second trimester. It allows better tissue contrast images than does US, a large field of view of the foetus and is not limited by large maternal body habitus and oligohydramnios, without any risk for the foetus. In the future, the development of new techniques (diffusion-weighted imaging, proton MR spectroscopy) and faster sequences will make it possible to widen the indications i.e. cardiac, functional renal and cerebral imaging.
Subject(s)
Congenital Abnormalities/diagnosis , Magnetic Resonance Imaging , Prenatal Diagnosis/instrumentation , Female , Humans , Magnetic Resonance Imaging/adverse effects , Magnetic Resonance Imaging/methods , Pregnancy , Pregnancy Trimester, SecondABSTRACT
OBJECTIVE: Evaluate the advantages of color Doppler and pulsed Doppler in the diagnosis and prognosis of fetal pulmonary malformations. MATERIALS AND METHOD: This retrospective study of 24 fetuses explored pulmonary malformations using sonography. A classification into four groups was made based on the presence of cysts and the echogenicity of the lesion, then analysis of video recordings including Doppler with an interpretation chart: afferent vessel, color chart, spectrum shape (afferent vessel and within the malformation) to determine the contribution of Doppler within each group. RESULTS: Four lesions were avascular: bronchogenic cysts (three cases), subphrenic sequestration (one case). The other lesions were vascularized and color Doppler determined the source of vascularization feeding the malformation: branches of the pulmonary artery in 13 cases (eight cases of cystic adenomatoid disease, two cases of atresia, and three airway obstacles) or the aorta in seven cases (pulmonary sequestrations) with pulmonary venous return, six cases (intralobular sequestrations), or systemic venous return, one case (extralobular sequestration). The pulsed Doppler recording in the malformation (six cases) completed the color Doppler examination by showing the different spectrum shapes according to the aortic or pulmonary source of flow. The color chart matched in three cases (normal pulmonary segmentation) and was heterogeneous in eight cases (parenchymatous dysplasia). Furthermore, perfusion intensity was correlated with lesion progression. CONCLUSION: Color Doppler and pulsed Doppler provided a more precise diagnosis of these malformations and seems to contribute prognostic information.
Subject(s)
Lung/abnormalities , Lung/diagnostic imaging , Ultrasonography, Doppler, Pulsed , Ultrasonography, Prenatal , Female , Humans , Pregnancy , Retrospective StudiesABSTRACT
We suggest the term 'hyper-echogenic colon' to describe a hyperechoic foetal colonic content with no other intestinal abnormality. This is a rare pattern, which to our knowledge, has never been correlated with a specific pathology. The accidental observation of a cystine kidney stone in an infant who presented with this sign during the prenatal period made it possible to diagnose this disease retrospectively in two other children.