ABSTRACT
Foramen magnum meningioma poses a challenge for neurosurgeons. Prognosis has generally improved with diagnostic and surgical advances over the past two decades; however, it may ultimately depend more on the surgeon's ability to tailor the approach and interpret intraoperative risks in single cases. The series comprised 64 patients operated on for ventral and ventrolateral foramen magnum meningioma. All patients underwent preoperative magnetic resonance imaging and received surgery via the dorsolateral route, rendering the series homogeneous in neuroradiological workup and surgical treatment. Particular to this series was that the majority of patients were of advanced age (n = 29; age, >65 years), had serious functional impairment (n = 30, Karnofski score <70), and large tumors (mean diameter, 3.5 cm). Total tumor removal was achieved in 52 (81 %) patients; operative mortality was nil. Early outcome varied depending on difficulties encountered at surgery (cranial nerve position and type of involvement in particular) and type of preoperative dysfunction. Long-tract signs and cerebellar deficits improved in 74 and 77 % of cases, respectively, but only 27 % of cranial nerve deficits did so. Surgical complications most often involved the cranial nerves: cranial nerve impairment, especially of the 9th through the 12th cranial nerves, due to stretching or encasement was noted in 44 cases. At final outcome assessment, two thirds of the cranial nerve deficits cleared, and all but two patients returned to a normal productive life. One patient was reoperated on during the follow-up period. Foramen magnum meningiomas behave like clival or spinal tumors depending on their prevalent extension. A dorsolateral approach tailored to tumor position and extension and meticulous surgical technique allow for definitive control of surgical complications. Scrupulous postoperative care may prevent dysphagia, a major persistent complication of surgery. Long-term observation of indolent tumor behavior at follow-up suggests that incomplete resection may be a viable surgical treatment option.
Subject(s)
Foramen Magnum/surgery , Meningioma/surgery , Skull Base Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Female , Foramen Magnum/pathology , Humans , Male , Meningioma/diagnosis , Meningioma/pathology , Middle Aged , Neurosurgical Procedures , Postoperative Complications/pathology , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/pathology , Treatment OutcomeABSTRACT
BACKGROUND: A limited number of reports on the long-term neurologic outcome of patients with SDAVFs treated by surgery and/or embolization are available in the literature. The aim of our study is to neurologically evaluate these patients at 2 different follow-up stages, after surgery, to demonstrate a possible late neurologic deterioration after an initial improvement. METHODS: Between January 1987 and May 2002, 29 patients with SDAVFs were operated on at the Verona Department of Neurosurgery. In this group we retrospectively identified 16 patients who had 2 different clinical follow-ups, at a mean of 4.5 and 9.2 years, respectively. We compared their neurologic status using the ALS. All these data were obtained from clinical charts and phone interviews. RESULTS: The epidemiologic, clinical, and radiologic features of our group of patients are very similar to those previously described in the literature. Comparing the global clinical status between the 2 different follow-up stages, we observed a late deterioration in 8 cases (50%). A worsening of the mean G and M values of the ALS was also noted. Spinal angiography and contrast-enhanced MRI did not show any signs of recurrence of the fistula. CONCLUSIONS: Our study confirms the possible occurrence of a late clinical deterioration in as many as 50% of patients surgically treated for a SDAVF. We deem that the main pathophysiologic mechanism underlining this phenomenon is a gradual and irreversible decline in spinal function related to those hemodynamic modifications induced by the fistula and to the persistence of a state of anatomofunctional deficiency of the spinal venous drainage.
Subject(s)
Central Nervous System Vascular Malformations/physiopathology , Central Nervous System Vascular Malformations/surgery , Psychomotor Performance , Adult , Aged , Angiography , Central Nervous System Vascular Malformations/diagnosis , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Medical Records , Middle Aged , Research Design , Retrospective Studies , Surveys and Questionnaires , Telephone , Time Factors , Treatment OutcomeABSTRACT
Spinal cavernous angiomas are rare vascular malformations occurring mainly in the vertebral body with or without an extradural extension. Only 3-5% of these lesions are entirely located in the spinal canal where they can occupy an extradural, intradural-extramedullary or intramedullary position. We present a 75-year-old woman with signs and symptoms of multiple lumbar radiculopathy. The lumbosacral MRI showed an intradural cauda equina lesion with heterogeneous contrast enhancement that was subsequently radically removed through an L3-L4 laminectomy. The microscopic appearance was suggestive of cavernous angioma with intraneural growth. Clinical, radiological, and surgical features of this unusual lesion (to date, only 12 cases are reported) are discussed.
Subject(s)
Cauda Equina/pathology , Hemangioma, Cavernous, Central Nervous System/complications , Hemangioma, Cavernous, Central Nervous System/pathology , Polyradiculopathy/etiology , Polyradiculopathy/pathology , Aged , Blood Vessels/pathology , Blood Vessels/physiopathology , Cauda Equina/physiopathology , Cauda Equina/surgery , Decompression, Surgical , Female , Hemangioma, Cavernous, Central Nervous System/physiopathology , Humans , Laminectomy , Lumbar Vertebrae/pathology , Lumbar Vertebrae/physiopathology , Lumbar Vertebrae/surgery , Magnetic Resonance Imaging , Polyradiculopathy/physiopathology , Radiculopathy/etiology , Radiculopathy/pathology , Radiculopathy/physiopathology , Spinal Canal/pathology , Spinal Canal/physiopathology , Spinal Canal/surgeryABSTRACT
In spite of advancements in neuro-imaging and microsurgical techniques, surgery for intramedullary spinal cord tumors (ISCT) remains a challenging task. The rationale for using intraoperative neurophysiological monitoring (IOM) is in keeping with the goal of maximizing tumor resection and minimizing neurological morbidity. For many years, before the advent of motor evoked potentials (MEPs), only somatosensory evoked potentials (SEPs) were monitored. However, SEPs are not aimed to reflect the functional integrity of motor pathways and, nowadays, the combined used of SEPs and MEPs in ISCT surgery is almost mandatory because of the possibility to selectively injury either the somatosensory or the motor pathways. This paper is aimed to review our perspective in the field of IOM during ISCT surgery and to discuss it in the light of other intraoperative neurophysiologic strategies that have recently appeared in the literature with regards to ISCT surgery. Besides standard cortical SEP monitoring after peripheral stimulation, both muscle (mMEPs) and epidural MEPs (D-wave) are monitored after transcranial electrical stimulation (TES). Given the dorsal approach to the spinal cord, SEPs must be monitored continuously during the incision of the dorsal midline. When the surgeon starts to work on the cleavage plane between tumor and spinal cord, attention must be paid to MEPs. During tumor removal, we alternatively monitor D-wave and mMEPs, sustaining the stimulation during the most critical steps of the procedure. D-waves, obtained through a single pulse TES technique, allow a semi-quantitative assessment of the functional integrity of the cortico-spinal tracts and represent the strongest predictor of motor outcome. Whenever evoked potentials deteriorate, temporarily stop surgery, warm saline irrigation and improved blood perfusion have proved useful for promoting recovery, Most of intraoperative neurophysiological derangements are reversible and therefore IOM is able to prevent more than merely predict neurological injury. In our opinion combining mMEPs and D-wave monitoring, when available, is the gold standard for ISCT surgery because it supports a more aggressive surgery in the attempt to achieve a complete tumor removal. If quantitative (threshold or waveform dependent) mMEPs criteria only are used to stop surgery, this likely impacts unfavorably on the rate of tumor removal.
Subject(s)
Monitoring, Intraoperative/methods , Monitoring, Intraoperative/trends , Spinal Cord Neoplasms/surgery , Female , Humans , MaleABSTRACT
OBJECTIVE: Glomus jugulare tumors are generally considered slow-growing, benign lesions. However, their pronounced local aggressiveness frequently results in severe neurological deficits. Surgical removal is rarely radical and is usually associated with morbidity. There is increasing evidence that stereotactic radiosurgery, particularly gamma knife radiosurgery (GKR), may play a relevant role as a therapeutic option in these tumors. METHODS: Between 1996 and 2005, we used GKR to treat 20 patients bearing growing glomus jugulare tumors, mostly classified as Glasscock-Jackson Grade IV or Fisch Stage D1. Follow-up (mean, 50.85 mo) data was available for 20 patients (four men, 16 women; mean age, 56 yr): eight out of 20 tumors were surgical recurrences, three out of 20 patients had GKR as the primary treatment, and 11 out of 20 patients previously underwent endovascular embolization. Regarding the radiosurgical dose planning, the average tumor volume was 7.03 cm (range, 1.5-13.4 cm) and the mean marginal dose was 17.3 Gy (range, 13-24 Gy). RESULTS: Neurological signs and symptoms were unchanged in 13 out of 20 patients. An improvement of cranial nerve function was observed in five patients and hearing deterioration was observed in two patients. Tumor volume was unchanged in 11 out of 20 patients and was slightly (Subject(s)
Glomus Jugulare Tumor/surgery
, Radiosurgery/instrumentation
, Radiosurgery/methods
, Adult
, Aged
, Female
, Follow-Up Studies
, Glomus Jugulare Tumor/diagnostic imaging
, Humans
, Male
, Middle Aged
, Radiography
ABSTRACT
OBJECTIVE: The value of intraoperative neurophysiological monitoring (INM) during intramedullary spinal cord tumor surgery remains debated. This historical control study tests the hypothesis that INM monitoring improves neurological outcome. METHODS: In 50 patients operated on after September 2000, we monitored somatosensory evoked potentials and transcranially elicited epidural (D-wave) and muscle motor evoked potentials (INM group). The historical control group consisted of 50 patients selected from among 301 patients who underwent intramedullary spinal cord tumor surgery, previously operated on by the same team without INM. Matching by preoperative neurological status (McCormick scale), histological findings, tumor location, and extent of removal were blind to outcome. A more than 50% somatosensory evoked potential amplitude decrement influenced only myelotomy. Muscle motor evoked potential disappearance modified surgery, but more than 50% D-wave amplitude decrement was the major indication to stop surgery. The postoperative to preoperative McCormick grade variation at discharge and at a follow-up of at least 3 months was compared between the two groups (Student's t tests). RESULTS: Follow-up McCormick grade variation in the INM group (mean, +0.28) was significantly better (P = 0.0016) than that of the historical control group (mean, -0.16). At discharge, there was a trend (P = 0.1224) toward better McCormick grade variation in the INM group (mean, -0.26) than in the historical control group (mean, -0.5). CONCLUSION: The applied motor evoked potential methods seem to improve long-term motor outcome significantly. Early motor outcome is similar because of transient motor deficits in the INM group, which can be predicted at the end of surgery by the neurophysiological profile of patients.
Subject(s)
Astrocytoma/surgery , Ependymoma/surgery , Evoked Potentials, Motor , Monitoring, Intraoperative , Spinal Cord Neoplasms/surgery , Adolescent , Adult , Aged , Astrocytoma/physiopathology , Case-Control Studies , Child , Ependymoma/physiopathology , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Muscle, Skeletal/physiopathology , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/pathology , Spinal Cord Neoplasms/physiopathology , Treatment OutcomeABSTRACT
OBJECT: The authors conducted a study to evaluate the long-term outcomes and prognostic factors for survival in a large series of patients treated by gamma knife surgery (GKS) for non-small cell lung cancer (NSCLC) brain metastases. METHODS: The study is based on the retrospective analysis of clinical and radiological records obtained during a 10-year period (1993-2003), concerning 836 lesions in 504 patients. The lesions were primary in 86% and recurrent 14% of the cases; they were solitary in 31%, single in 29%, and multiple in 40%. The mean follow-up period was 16 months (range 4-113 months). The most common histological types were adenocarcinoma (51%) and squamous cell carcinoma (27%). Dose planning parameters were as follows: mean target volume 6.2 cm3 (range 0.06-22.5 cm3); mean prescription dose 21.4 Gy (range 15.5-28 Gy); and mean number of isocenters 6.7 (range one-18). Progression-free and actuarial survival curves were calculated using the Kaplan-Meier method. The main factors affecting survival were determined by unimultivariate analysis (log-rank test and Cox proportional hazard models). Analysis of long-term outcomes seemed to confirm that GKS is a primary therapeutic option in these patients. The 1-year local tumor control rate was 94%. The overall median survival was 14.5 months, with extremely rewarding quality of life indices. The recursive partitioning analysis classification was the dominant prognostic factor. CONCLUSIONS: Gamma knife surgery is a useful treatment for brain metastases from NSCLC.
Subject(s)
Adenocarcinoma/secondary , Adenocarcinoma/surgery , Brain Neoplasms/secondary , Brain Neoplasms/surgery , Carcinoma, Non-Small-Cell Lung/secondary , Carcinoma, Non-Small-Cell Lung/surgery , Carcinoma, Squamous Cell/secondary , Carcinoma, Squamous Cell/surgery , Lung Neoplasms/surgery , Radiosurgery/instrumentation , Adult , Aged , Aged, 80 and over , Humans , Middle Aged , Radiation Dosage , Retrospective Studies , TimeABSTRACT
OBJECTS: The authors report their experience of gamma knife radiosurgery (GKR) in a large series of pediatric cerebral arteriovenous malformations (cAVMs). The advantages, risks and failures of this approach are presented and discussed. METHODS: Gamma knife radiosurgery was performed on 63 children aged < or =16 years. Haemorrhage was the clinical onset in 50 out of 63 cases. The mean pre-GK cAVM volume was 3.8 cm(3). Fifty-eight out of 63 cAVMs were Spetzler-Martin grades I-III. Most lesions (47 out of 63) were in eloquent or deep-seated brain regions. CONCLUSION: Gamma knife radiosurgery-related complications occurred in 2 out of 47 cases with an available follow-up (1 had transient and 1 permanent morbidity). No bleeding occurred during the latency period. In 39 children with >36-month follow-up, complete cAVM occlusion was angiographically documented in 31, with a 3- and 4-year actuarial obliteration rate of 72 and 77% respectively. High rates of complete obliteration and very low frequency of permanent morbidity with no bleeding during the latency period encourage widespread application of GKR in the treatment of pediatric cAVMs.
Subject(s)
Intracranial Arteriovenous Malformations/surgery , Radiosurgery/methods , Adolescent , Cerebral Angiography/methods , Cerebral Hemorrhage/surgery , Child , Child, Preschool , Female , Humans , Intracranial Arteriovenous Malformations/physiopathology , Male , Postoperative Complications , Retrospective Studies , Treatment OutcomeSubject(s)
Medicine in the Arts , Mythology , Paintings/history , Famous Persons , History, 16th Century , Humans , ItalyABSTRACT
OBJECT: This study was performed to further elucidate technical and patient-specific risk factors for perioperative stroke in patients undergoing temporary arterial occlusion during the surgical repair of their aneurysms. METHODS: One hundred twelve consecutive patients in whom temporary arterial occlusion was performed during surgical repair of an aneurysm were retrospectively analyzed. Confounding factors (inadvertent permanent vessel occlusion and retraction injury) were identified in six cases (5%) and these were excluded from further analysis. The demographics for the remaining 106 patients were analyzed with respect to age, neurological status, aneurysm characteristics, intraoperative rupture, duration of temporary occlusion, and number of occlusive episodes; end points considered were outcome at 3-month follow up and symptomatic and radiological stroke. CONCLUSIONS: Overall 17% of patients experienced symptomatic stroke and 26% had radiological evidence of stroke attributable to temporary arterial occlusion. A longer duration of clip placement, older patient age, a poor clinical grade (Hunt and Hess Grades IV-V), early surgery, and the use of single prolonged clip placement rather than repeated shorter episodes were associated with a higher risk of stroke based on univariate analysis. Intraoperative aneurysm rupture did not affect stroke risk. On multivariate analysis, only poorer clinical grade (p = 0.001) and increasing age (p = 0.04) were significantly associated with symptomatic stroke risk.
Subject(s)
Aneurysm, Ruptured/epidemiology , Aneurysm, Ruptured/surgery , Intracranial Aneurysm/epidemiology , Intracranial Aneurysm/surgery , Stroke/epidemiology , Adult , Age Distribution , Aged , Aged, 80 and over , Cerebral Hemorrhage/epidemiology , Cerebral Hemorrhage/surgery , Female , Humans , Intraoperative Complications/epidemiology , Ischemic Attack, Transient/epidemiology , Ischemic Attack, Transient/surgery , Male , Middle Aged , Prognosis , Reperfusion Injury/epidemiology , Reperfusion Injury/surgery , Risk FactorsABSTRACT
OBJECT: The purpose of this investigation was to describe and compare through cadaveric dissection the microsurgical exposure afforded by the median, paramedian, and extreme-lateral infratentorial-supracerebellar approaches to the posterior and middle incisural space. METHODS: The median, paramedian, and extreme-lateral infratentorial-supracerebellar approaches were performed in 10 embalmed cadaveric heads by using standard microneurosurgical methods; each approach was executed a minimum of five times. The dissections were performed in a stepwise fashion, comparing the exposure afforded by each surgical route and highlighting the relationships among the targeted neurovascular structures. Exposure of the dural sinuses and transection of the tentorium were also evaluated in relation to the degree of exposure achieved. The median infratentorial-supracerebellar route provides direct exposure of the posterior incisural space, although the culmen represents a relative obstacle to exposure of the lower quadrigeminal plate. The paramedian variant allows a more lateral perspective on the posterolateral brainstem surface at the level of the middle incisural space, in addition to exposing the homolateral collicular plate. The extreme-lateral corridor widens the exposure of the paramedian approach to include the anterolateral brainstem surface, offering a complete view of the cisternal space surrounding the middle incisural space. Complete, constant exposure and retraction of the dural sinuses facilitated the surgical exposure. CONCLUSIONS: The infratentorial-supracerebellar approaches allow safe circumferential exposure of the posterior and middle incisural space. Choosing among different variants allows the surgeon to reach selected areas, with the midline variant being best for exposure of the posterior incisural space, and the paramedian and extreme-lateral variants being best for reaching the posterior and the anterior part of the middle incisural space, respectively. The more lateral the approach, the more anterior and multiangled the exposure gained. Complete, constant exposure and retraction of the dural sinuses improves the exposure. Accurate knowledge of the regional anatomy is mandatory.
Subject(s)
Cerebellum/anatomy & histology , Cranial Fossa, Posterior/anatomy & histology , Craniotomy/methods , Mesencephalon/anatomy & histology , Cadaver , Cerebellum/surgery , Cranial Fossa, Posterior/surgery , Cranial Nerves/anatomy & histology , Cranial Nerves/surgery , Humans , Mesencephalon/surgeryABSTRACT
OBJECTIVE: To evaluate the efficacy of gamma knife (GK) radiosurgery, in terms of neurological improvement and tumor growth control (TGC), for a large series of patients with cavernous sinus meningiomas. METHODS: Between February 1993 and January 2002, 156 patients with cavernous sinus meningiomas (35 male and 121 female patients; mean age, 56.1 yr) were treated with GK radiosurgery in our department. GK radiosurgery was used as a first-choice treatment for 75 of 156 patients and as postoperative adjuvant therapy for 81 of 156 patients (all with Grade I meningiomas). Eligibility criteria for radiosurgery were as follows: symptomatic meningiomas and/or documented tumor progression on magnetic resonance imaging scans, conditions of high operative risk, patient refusal of microsurgery or reoperation, tumor volume of <20 cm(3), and location no less than 2 mm from the optic pathways. RESULTS: Follow-up data for at least 12 months were available for 122 patients (median follow-up period, 48.9 mo). Clinical conditions were improved or stable for 118 of 122 patients (97%). Neurological recovery was observed for 78.5% of patients treated with GK radiosurgery alone and for 60.5% of patients treated with adjuvant therapy (P < 0.05). Adequate TGC was documented for 119 of 122 tumors (97.5%), with shrinkage/disappearance in 75 of 122 cases (61.5%) and no variation in volume in 44 of 122 cases (36%); the overall actuarial progression-free survival rate at 5 years was 96.5%. Tumor size regression was observed for 80% of patients with follow-up periods of more than 30 months, compared with 43.5% of patients with follow-up periods of less than 30 months (P < 0.0002). Radiosurgical sequelae were transient in 4 of 122 cases (3.0%) and permanent in 1 case (1%). CONCLUSION: For the follow-up periods in our series (median, >4 yr), GK radiosurgery seems to be both safe (permanent morbidity rate, 1%) and effective (97% neurological improvement/stability, 97.5% overall TGC, and 96.5% actuarial TGC at 5 yr). GK radiosurgery might be considered a first-choice treatment for selected patients with cavernous sinus meningiomas.
Subject(s)
Cavernous Sinus , Meningeal Neoplasms/surgery , Meningioma/surgery , Radiosurgery , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Meningeal Neoplasms/radiotherapy , Middle Aged , Radiosurgery/adverse effects , Radiotherapy, Adjuvant , Survival Analysis , Treatment OutcomeABSTRACT
PURPOSE: To evaluate the efficacy of Gamma Knife (GK) radiosurgery in terms of neurologic improvement and tumor growth control (TGC) in a large series of patients with cavernous sinus meningioma (CSM). METHODS AND MATERIALS: One hundred thirty-eight patients with CSM (28 males, 110 females; mean age: 56.2 years) were treated with GK between February 1993 and February 2001. GK was used as a first-choice treatment in 68/138 patients and as postoperative adjuvant therapy in 70/138. In 32 patients, it was possible to compare the size of the planned treatment volume to tumor volume using the conformity index (CI); optimal CI values were taken to be < or =1.5 (range: 0.94-2.24). RESULTS: A follow-up (FU) period of at least 12 months was available for 111 patients (median: 48.2 months, range: 12.1-84.5 months). Clinical conditions were improved or stable in 107/111 patients (96.5%). Neurologic recovery was observed in 76% of cases treated by GK alone and in 56.5% of adjuvant treatments (p < 0.03). Adequate TGC was documented in 108/111 tumors (97%), with shrinkage/disappearance in 70/111 (63%) and no variation in volume in 38/111 (34%); the overall actuarial progression-free survival rate at 5 years was 96%. Tumor size regression was observed in 79.5% of patients with FU >30 months, compared with 47.5% of patients with FU <30 months (p < 0.001). One hundred percent TGC was shown in treated patients with a CI < or =1.5 (20/32), compared with 92% TGC in cases with a CI >1.5 (p < 0.15, NS). Radiosurgical sequelae were transient in 4/111 cases (3.5%) and permanent in one case (1%). CONCLUSIONS: For the FU period of our series (median: >4 years), GK radiosurgery seems to be both safe (permanent morbidity 1%) and effective (96% neurologic improvement/stability, 97% overall TGC, 96% actuarial TGC at 5 years) and might be considered as a first-choice treatment for selected patients with CSM.
Subject(s)
Meningeal Neoplasms/surgery , Meningioma/surgery , Radiosurgery/methods , Adult , Aged , Aged, 80 and over , Brain/pathology , Disease-Free Survival , Female , Humans , Male , Middle Aged , Time Factors , Treatment OutcomeABSTRACT
OBJECT: The aim of this retrospective study was to assess the role of gamma knife radiosurgery (GKS) as a primary treatment for brain metastases by evaluating the results in particularly difficult cases such as oncotypes-which are unresponsive to radiation-cystic lesions, and highly critical locations such as the brainstem. METHODS: Treatment of 804 patients with 1307 solitary (29%), single (26%), and multiple (45%) brain metastases was evaluated. Treatment planning parameters were as follows: mean tumor volume 4.8 cm3 (range 0.01-21.5 cm3), mean prescription dose 20.6 Gy (range 12-29 Gy), and mean number of isocenters 6.5 (one-19). In unresponsive oncotypes such as melanoma and renal cell carcinoma, the mean target dosages were higher. Cystic metastatic lesions were initially stereotactically evacuated and then GKS was performed. Patients with brainstem metastases were treated with lower doses. Conventional radiotherapy was used in only a minority (14%) of selected cases. The overall median patient survival time was 13.5 months, and the 1-year actuarial local progression-free survival rate was 94%, with a mean palliation index and functional independence index of 53.8 and 52.5 weeks, respectively. The local tumor control rate was 93%, with a mean follow-up period of 14 months. In the overall series, and especially in the unresponsive oncotypes, systemic disease progression was the main limiting factor with regard to patient life expectancy. CONCLUSIONS: Gamma knife radiosurgery seems to be the primary treatment option for patients harboring small-to-medium size (< or = 20-cm3) brain metastases with reasonable life expectancy and no impending intracranial hypertension. Results are better than with those obtained using whole-brain radiotherapy and comparable to the best selected surgery-radiation series, even in oncotypes unresponsive to therapeutic radiation, cystic tumors, and tumors located in the brain stem.