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Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics.
Lalwani, Nikhil; Chen, Yu-Su; Brooke, Gemma; Cross, Neil A; Allen, David W; Reynolds, Alan; Ojeda, Jesús; Tizzard, Graham J; Coles, Simon J; Bricklebank, Neil.
Chem Commun (Camb) ; 51(19): 4109-11, 2015 Mar 07.
Article in English | MEDLINE | ID: mdl-25670649

ABSTRACT

Two new triphenylarsonium alkylthiolate precursors, a thiosulfate zwitterion and a thioacetate salt, have been structurally characterised and their cytotoxicity evaluated against PC3 cells. The arsonium compounds have been used to prepare gold nanoparticles decorated with triphenylarsonium groups.


Subject(s)
Arsenicals/chemistry , Arsenicals/pharmacology , Drug Carriers/chemistry , Gold/chemistry , Intracellular Space/drug effects , Metal Nanoparticles/chemistry , Cell Line, Tumor , Cell Survival/drug effects , Humans , Models, Molecular , Molecular Conformation , Sulfates/chemistry
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