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1.
Cardiovasc Intervent Radiol ; 46(3): 337-349, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36653660

ABSTRACT

PURPOSE: The primary objectives of this study were to evaluate safety, and efficacy of Transarterial Chemoembolization (TACE) using doxorubicin-loaded radiopaque microspheres (DC Bead LUMI™) for the treatment of early and intermediate stage Hepatocellular Carcinoma (HCC) not amenable for curative treatments. Distribution of the microspheres was correlated with results post embolization. MATERIALS AND METHODS: This was a prospective, single arm, open label study. The primary outcome measures were distribution of the radiopaque microspheres as showed by computerized tomography (CT) and local response measured by modified Response Evaluation Criteria (mRECIST) after Magnetic Resonance Imaging (MRI). Secondary measures were Time to Progression (TTP) and Overall Survival (OS). RESULTS: Fifty patients were enrolled over 36 months. Median age was 69.0 years; mean sum of target lesions diameters was 78.6 ± 36.8 mm. There were no Grade 4 or 5 adverse events (AEs). At 6 months Complete Response (CR) (18%), Partial Response (PR) (62%), Objective Response OR (80%) and Stable Disease (SD) (20%) were recorded. Before embolization, Diffusion Weighted Imaging (DWI) showed high signal (restricted diffusion). Post procedure, patients with dense deposition (< 5 mm distance of microsphere aggregations) showed 100% absence of enhancement and no restriction in 30.6%. Median TTP was 8.3 months. TTP for patients with CR was 13.3 months and 7.2 and 5.6 for PR and SD, respectively. At 6 and 36 months, survival was 94% and 34%, respectively. CONCLUSION: DC Bead LUMI™ is well tolerated and effective in early and intermediate stage HCC with maximal necrosis obtained in dense deposition in the target.


Subject(s)
Carcinoma, Hepatocellular , Chemoembolization, Therapeutic , Liver Neoplasms , Humans , Aged , Carcinoma, Hepatocellular/therapy , Carcinoma, Hepatocellular/drug therapy , Liver Neoplasms/therapy , Liver Neoplasms/drug therapy , Prospective Studies , Chemoembolization, Therapeutic/methods , Doxorubicin , Microspheres , Treatment Outcome , Antibiotics, Antineoplastic
2.
Eur J Orthop Surg Traumatol ; 31(8): 1625-1630, 2021 Dec.
Article in English | MEDLINE | ID: mdl-33709268

ABSTRACT

PURPOSE: Osteoid osteomas in the spine constitute a challenging group for both surgical and percutaneous approaches. Purpose of the present study is to report a case report of a spinal osteoid osteoma in a challenging spinal location and review literature for safety and efficacy of the technique. METHODS: We report a case of spinal osteoid osteoma extending in the epidural space and abutting the dura in a pediatric patient treated by percutaneous computed tomography-guided radiofrequency ablation. This is not a systematic review of the literature. A number of separate literature searches were performed. Non-English studies and case reports were excluded from the study. All references of the obtained articles were also evaluated for any additional information. RESULTS: Although all prophylactic measures were taken (hydrodissection, thermocouples and neurophysiologic monitoring) and the procedure was uneventful, patient within three hours, was unable to raise or bend the unilateral lower extremity below the knee. Pain reduction was significant from the first morning post-ablation and during the follow-up period of 18 months. MR scan was within normal limits. Dexamethasone was iv injected for 24 h and prescribed per os for 7 days. At follow-up 1 week later mobility of the lower extremity had returned to normal. CONCLUSION: As far as spine ablation is concerned, all prophylactic measures should be taken; neurophysiologic monitoring seems to be more sensitive than temperature measurement. Intravenous and per os corticosteroids are extremely useful in case of nerve damage.


Subject(s)
Bone Neoplasms , Catheter Ablation , Osteoma, Osteoid , Radiofrequency Ablation , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/surgery , Child , Humans , Osteoma, Osteoid/diagnostic imaging , Osteoma, Osteoid/surgery , Tomography, X-Ray Computed , Treatment Outcome
3.
Radiat Prot Dosimetry ; 190(2): 150-157, 2020 Aug 28.
Article in English | MEDLINE | ID: mdl-32626896

ABSTRACT

The aim of the study was to measure and evaluate the radiation dose to the eye lens and forehead of interventional radiologists (IRs). The study included 96 procedures (lower-limb percutaneous transluminal angioplasties, embolisations/chemoembolisations and vertebroplasties) performed by 6 IRs. A set of seven thermoluminescence dosemeters was allocated to each physician. The highest dose per procedure was found for the left eye lens of the primary operator in vertebroplasties (1576 µSv). Left and right eye doses were linearly correlated to left and right forehead doses, respectively. A workload-based estimation of the annual dose to participating IRs revealed that the occupational dose limit for the eye lens can be easily exceeded. The left eye dose of ΙRs must be routinely monitored on a personalised basis. Τhe left eye dose measurement provides a reliable assessment of the ipsilateral forehead dose, along with valid estimations for the right eye and right forehead doses.


Subject(s)
Lens, Crystalline , Occupational Exposure , Radiation Protection , Forehead , Humans , Occupational Exposure/analysis , Radiation Dosage , Radiologists , Radiology, Interventional
4.
Eur J Neurol ; 27(7): 1343-1349, 2020 07.
Article in English | MEDLINE | ID: mdl-32250518

ABSTRACT

BACKGROUND AND PURPOSE: The purpose was to investigate our centre's experience on computed-tomography-guided (CT-guided), transforaminal, intrathecal administration of nusinersen in adult subjects with spinal muscular atrophy (SMA) type 2 and severe spinal deformity. METHOD: This is a retrospective, single-centre study investigating the feasibility and safety of CT-guided, transforaminal, lumbar puncture for the intrathecal administration of nusinersen (Spinranza®; Biogen; Cambridge, MA, USA) in a cohort of adult subjects with SMA type 2, severe neuromuscular scoliosis and previous spinal surgery. Between January 2019 and October 2019, five male, adult, SMA type 2 subjects were eligible to be treated in our centre with nusinersen. The mean age of the patients was 31 ± 9 years (range 19-43 years). The study's outcome measures were technical success, adverse events and radiation exposure. RESULTS: In total, four patients completed the four loading doses, whilst the fifth patient received only one loading dose; two patients also received their first maintenance doses. Overall, 20 consecutive transforaminal, intrathecal treatments were analysed. Technical success was 100% (20/20 intrathecal infusions). No adverse events were documented following the procedures. Mean dose-length product (DLP) value per injection was 665.4 ± 715.5 mGy*cm. Estimated mean effective dose per injection was 12.7 ± 12.9 mSv. Subgroup analysis between the chronologically first 10 versus subsequent 10 procedures demonstrated a clear trend towards less radiation exposure in the latter, although this difference did not reach statistical significance (DLP: 984.7 ± 903.3 vs. 436.7 ± 321.5 mGy*cm, P = 0.165; respectively). CONCLUSIONS: In this retrospective series, CT-guided transforaminal access for intrathecal injection of nusinersen was proven feasible and safe. A decrease in radiation dose over time was noted. Protocols to minimize radiation exposure are essential.


Subject(s)
Radiation Exposure , Spinal Muscular Atrophies of Childhood , Adult , Feasibility Studies , Humans , Injections, Spinal , Male , Oligonucleotides , Retrospective Studies , Spinal Muscular Atrophies of Childhood/drug therapy , Tomography, X-Ray Computed , Young Adult
5.
J Long Term Eff Med Implants ; 30(2): 113-118, 2020.
Article in English | MEDLINE | ID: mdl-33426849

ABSTRACT

Piriformis syndrome (PS), first described by Yeoman in 1928, is a general term referring to low back pain, sciatica, and instability. PS has a 6% incidence rate worldwide. In this study, we aim to retrospectively evaluate the effectiveness of computed tomography (CT)-guided percutaneous infiltration in a series of consecutive PS patients who have symptoms that are refractory to conservative therapies. An institutional database search identified 20 such consecutive patients who underwent infiltration with a mixture of long-acting corticosteroid and local anesthetic. Preoperational evaluation included physical examination and magnetic resonance imaging. The correct position of the 22-gauge spinal needle was verified with CT scan after contrast medium injection. Pain measured before the procedure and at 1 wk and 1, 6, and 12 mo after the procedure was compared by means of a numeric visual scale (NVS) questionnaire. The mean pain score before CT-guided percutaneous infiltration was 8.95 ± 1.432 NVS units. This score was reduced to a mean value of 0.85 ± 0.933 units at 1 wk, 0.90 ± 0.852 at 1 mo, 1.10 ± 1.165 at 6 mo, and 1.20 ± 1.399 at 12 mo follow-up (p < 0.001). Two patients of 20 (10%) underwent a second infiltration that was performed at 7 and 10 d after the first, respectively. No complications were observed. CT-guided infiltration seems to be a feasible, efficacious, and safe approach for pain reduction and mobility improvement in patients with symptomatic PS.


Subject(s)
Piriformis Muscle Syndrome , Anesthetics, Local , Humans , Pain Measurement , Piriformis Muscle Syndrome/diagnostic imaging , Piriformis Muscle Syndrome/drug therapy , Retrospective Studies , Tomography, X-Ray Computed
6.
Diagn Interv Imaging ; 100(7-8): 391-400, 2019.
Article in English | MEDLINE | ID: mdl-30935863

ABSTRACT

Osteoarthritis of the knee is the most common cause of chronic knee pain being more prevalent in middle-aged and elderly patients. Symptomatic patients complain of pain and mobility impairment. Therapeutic armamentarium includes physical therapy, oral pharmacologic therapy, intra-articular injections, nerve ablation or modulation, trans-catheter arterial embolization, minimally invasive arthroscopic treatment and partial or total knee arthroplasty. Interventional radiology therapies for knee osteoarthritis include intra-articular injections, neurotomy and neuromodulation techniques as well as transcatheter intra-arterial therapies. These therapies aim to control pain and inflammation, improve mobility and function whilst the novel cell-based therapies have the potential for bone and cartilage regenerative repair facilitating the delay to surgery. The purpose of this review is to illustrate the technical aspects, the indications and the methodology of local therapies for knee osteoarthritis performed by interventional radiologists and provide current evidence.


Subject(s)
Knee Joint/diagnostic imaging , Osteoarthritis, Knee/therapy , Radiology, Interventional , Denervation , Embolization, Therapeutic , Glucocorticoids/therapeutic use , Humans , Hyaluronic Acid/therapeutic use , Injections, Intra-Articular , Mesenchymal Stem Cell Transplantation , Mobility Limitation , Osteoarthritis, Knee/diagnostic imaging , Platelet-Rich Plasma , Transcutaneous Electric Nerve Stimulation , Viscosupplements/therapeutic use
7.
Int J Hyperthermia ; 34(8): 1265-1269, 2018 12.
Article in English | MEDLINE | ID: mdl-29417855

ABSTRACT

OBJECTIVES: To prospectively evaluate the effectiveness of intra-articular application of pulsed radiofrequency (PRF) combined with viscosupplementation in patients with knee osteoarthritis suffering from chronic pain refractory to conservative therapies. METHODS: During a 30-month period, PRF combined with viscosupplementation was performed on 53 cases of knee osteoarthritis (45 patients, 8/45 with bilateral knee osteoarthritis). Pre-operational imaging included standard knee X-rays on anterior-posterior and lateral views used to evaluate patients according to the Kellgren-Lawrence classification. Pain, prior, one week/one, 6 and 12 months post were compared by means of a numeric visual scale (NVS) questionnaire. RESULTS: Mean pain score prior to PRF was 8.19 ± 1.4 NVS units. This score was reduced to a mean value of 2.47 ± 2.5 NVS units at 1 week after, 2.55 ± 2.6 at 1 month, 3.1 ± 2.8 at 6 months and 5.02 ± 3.09 at 12 months of follow-up (p < 0.01). Overall mobility improved in 47/53 (88.6%) patients. No complication was observed. CONCLUSIONS: Combining PRF with viscous supplementation is an effective and safe technique for palliative management of chronic pain in patients with knee osteoarthritis. Results seem to be reproducible and long lasting. There seems to be a need of repeating the session at 1 year.


Subject(s)
Osteoarthritis, Knee , Pulsed Radiofrequency Treatment , Viscosupplementation , Humans , Prospective Studies , Radiofrequency Ablation , Treatment Outcome
8.
Int J Hyperthermia ; 34(7): 1077-1081, 2018 11.
Article in English | MEDLINE | ID: mdl-29202667

ABSTRACT

OBJECTIVES: Percutaneous ablation is an expanding, minimally invasive approach for small- to medium-sized renal masses. The purpose of this study is to review safety, and mid-term efficacy of percutaneous microwave ablation (MWA) for Renal Cell Carcinoma (RCC) treatment using a high power microwave system. METHODS AND MATERIALS: Institutional database research identified 50 consecutive patients with a single lesion resembling renal cell carcinoma in CT and MRI who underwent percutaneous microwave ablation using a high power microwave system. All patients underwent biopsy on the same session with ablation using an 18G semi-automatic soft tissue biopsy needle. Contrast-enhanced computed tomography or magnetic resonance imaging was used for post-ablation follow-up. Patient and tumour characteristics, microwave technique, complications and pattern of recurrence were evaluated. RESULTS: Mean patient age was 74 years (male-female: 31-19). Average lesion size was 3.1 cm (range 2.0-4.3 cm). Biopsy results report RCC (n = 48), inflammatory myofibroblastic tumour (n = 1), and non-diagnostic sample (n = 1). The 3-year overall survival was 95.8% (46/48). Two patients died during the 3-year follow-up period due to causes unrelated to the MW ablation and to the RCC. Minor complications including haematomas requiring nothing but observation occurred at 4% (2/50) of the cases. Local recurrence of 6.25% (3/48) was observed with 2/3 cases being re-treated achieving a total clinical success of 97.9% (47/48 lesions). CONCLUSIONS: Percutaneous microwave ablation of RCC using a high power microwave system is a safe and efficacious technique for the treatment of small- to medium-sized renal masses.


Subject(s)
Carcinoma, Renal Cell/therapy , Catheter Ablation/methods , Microwaves/therapeutic use , Aged , Carcinoma, Renal Cell/diagnostic imaging , Carcinoma, Renal Cell/pathology , Female , Humans , Male
9.
Int J Hyperthermia ; 33(6): 670-674, 2017 09.
Article in English | MEDLINE | ID: mdl-28540776

ABSTRACT

OBJECTIVE: To evaluate safety and efficacy of radiofrequency ablation (RFA) in the treatment of painful intra-articular osteoid osteoma. MATERIALS AND METHODS: During the last 3 years, 15 patients underwent computed tomography (CT)-guided biopsy and RFA of symptomatic intra-articular osteoid osteoma. In order to assess and sample the nidus, a coaxial bone biopsy system was used. Biopsy was performed and followed by ablation session with osteoid osteoma protocol in all cases. Procedure time (i.e. drilling including local anaesthesia and ablation), amount of scans, the results of biopsy and pain reduction during follow-up period are reported. RESULTS: Access to the nidus through normal bone, biopsy and electrode insertion was technically feasible in all cases. Median procedure time was 54 min. Histologic verification of osteoid osteoma was performed in all cases. Median amount CT scans, performed to control correct positioning of the drill and precise electrode placement within the nidus was 9. There were no complications or material failure reported in our study. There was no need for protective techniques of the articular cartilage. Pain reduction was significant from the first morning post ablation and complete at the one week and during the follow-up period. No recurrences were noted. CONCLUSIONS: RFA under CT guidance is a safe and efficient technique for the treatment of painful intra-articular osteoid osteoma. Imaging guidance, extra-articular access through normal bone and exact positioning of the needle-electrode inside the nidus facilitate safety of the technique and prevention of damage to the articular cartilage.


Subject(s)
Ablation Techniques , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/surgery , Osteoma, Osteoid/diagnostic imaging , Osteoma, Osteoid/surgery , Tomography, X-Ray Computed , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Young Adult
10.
Eur J Vasc Endovasc Surg ; 53(2): 238-254, 2017 Feb.
Article in English | MEDLINE | ID: mdl-28007450

ABSTRACT

BACKGROUND: The widespread use of central venous catheters, ports, pacemakers, and defibrillators has increased the incidence of benign superior vena cava syndrome (SVCS). This study aimed at reviewing the results of open and endovascular treatment of SVCS. METHOD: Medical literature databases were searched for relevant studies. Studies with more than five adult patients, reporting separate results for the SVC were included. Nine studies reported the results of endovascular treatment of SVCS including 136 patients followed up for a mean of 11-48 months. Causes of SVCS were central venous catheters and pacemakers (80.6%), mediastinal fibrosis (13.7%), and other (5.6%). Percutaneous transluminal angioplasty (PTA) and stenting was performed in 73.6%, PTA only in 17.3%, and thrombolysis, PTA, and stenting in 9%. Four studies reported the results of open repair of SVCS including 87 patients followed up between 30 months and 10.9 years. The causes were mediastinal fibrosis (58.4%), catheters and pacemakers (28.5%), and other (13%). Operations performed included a spiral saphenous interposition graft, other vein graft, PTFE graft, and human allograft. Thirteen patients required re-operations (15%) before discharge mainly for graft thrombosis. RESULTS: In the endovascular group technical success was 95.6%. Thirty day mortality was 0%. Regression of symptoms was reported in 97.3%. Thirty-two patients (26.9%) underwent 58 secondary procedures. In the open group the 30 day mortality was 0%. Symptom regression was reported in 93.5%. Twenty-four patients (28.4%) underwent a total of 33 secondary procedures. CONCLUSIONS: Endovascular is the first line treatment for SVCS caused by intravenous devices, whereas surgery is most often performed for mediastinal fibrosis. Both treatments show good results regarding regression of the symptoms and mid-term primary patency, with a significant incidence of secondary interventions.


Subject(s)
Angioplasty, Balloon , Blood Vessel Prosthesis Implantation , Superior Vena Cava Syndrome/therapy , Thrombolytic Therapy , Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/instrumentation , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/instrumentation , Female , Graft Occlusion, Vascular/etiology , Humans , Male , Middle Aged , Risk Factors , Stents , Superior Vena Cava Syndrome/diagnostic imaging , Superior Vena Cava Syndrome/epidemiology , Superior Vena Cava Syndrome/physiopathology , Thrombolytic Therapy/adverse effects , Time Factors , Treatment Outcome , Vascular Patency
11.
Cardiovasc Intervent Radiol ; 39(10): 1499-505, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27230513

ABSTRACT

PURPOSE: To report our experience with the use of a battery-powered drill in biopsy and radiofrequency ablation of osteoid osteoma with excess reactive new bone formation. The battery-powered drill enables obtaining the sample while drilling. MATERIALS AND METHODS: During the last 18 months, 14 patients suffering from painful osteoid osteoma with excess reactive new bone formation underwent CT-guided biopsy and radiofrequency ablation. In order to assess and sample the nidus of the osteoid osteoma, a battery-powered drill was used. Biopsy was performed in all cases. Then, coaxially, a radiofrequency electrode was inserted and ablation was performed with osteoid osteoma protocol. Procedure time (i.e., drilling including local anesthesia), amount of scans, technical and clinical success, and the results of biopsy are reported. RESULTS: Access to the nidus through the excess reactive new bone formation was feasible in all cases. Median procedure time was 50.5 min. Histologic verification of osteoid osteoma was performed in all cases. Radiofrequency electrode was coaxially inserted within the nidus and ablation was successfully performed in all lesions. Median amount CT scans, performed to control correct positioning of the drill and precise electrode placement within the nidus was 11. There were no complications or material failure reported in our study. CONCLUSIONS: The use of battery-powered drill facilitates access to the osteoid osteoma nidus in cases where excess reactive new bone formation is present. Biopsy needle can be used for channel creation during the access offering at the same time the possibility to extract bone samples.


Subject(s)
Bone Neoplasms/pathology , Bone Neoplasms/surgery , Catheter Ablation/instrumentation , Image-Guided Biopsy/instrumentation , Minimally Invasive Surgical Procedures/instrumentation , Osteogenesis , Osteoma, Osteoid/pathology , Osteoma, Osteoid/surgery , Surgery, Computer-Assisted/instrumentation , Surgical Instruments , Tomography, X-Ray Computed/instrumentation , Adolescent , Adult , Female , Humans , Male , Operative Time , Osteogenesis/physiology
12.
Cardiovasc Intervent Radiol ; 39(1): 90-6, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26048014

ABSTRACT

PURPOSE: To evaluate clinical efficacy/safety of augmented peripheral osteoplasty in oncologic patients with long-term follow-up. MATERIALS AND METHODS: Percutaneous augmented peripheral osteoplasty was performed in 12 patients suffering from symptomatic lesions of long bones. Under extensive local sterility measures, anesthesiology care, and fluoroscopic guidance, direct access to lesion was obtained and coaxially a metallic mesh consisting of 25-50 medical grade stainless steel micro-needles (22 G, 2-6 cm length) was inserted. PMMA for vertebroplasty was finally injected under fluoroscopic control. CT assessed implant position 24-h post-treatment. RESULTS: Clinical evaluation included immediate and delayed follow-up studies of patient's general condition, NVS pain score, and neurological status. Imaging assessed implant's long-term stability. Mean follow-up was 16.17 ± 10.93 months (range 2-36 months). Comparing patients' scores prior (8.33 ± 1.67 NVS units) and post (1.42 ± 1.62 NVS units) augmented peripheral osteoplasty, there was a mean decrease of 6.92 ± 1.51 NVS units. Overall mobility improved in 12/12 patients. No complication was observed. CONCLUSION: Percutaneous augmented peripheral osteoplasty (rebar concept) for symptomatic malignant lesions in long bones seems to be a possible new technique for bone stabilization. This combination seems to provide necessary stability against shearing forces applied in long bones during weight bearing.


Subject(s)
Cementoplasty/methods , Fractures, Spontaneous/prevention & control , Neoplasms/complications , Pain Management/methods , Pain/etiology , Female , Femur/diagnostic imaging , Femur/pathology , Fluoroscopy , Follow-Up Studies , Humans , Humerus/diagnostic imaging , Humerus/pathology , Male , Tomography, X-Ray Computed , Treatment Outcome , Ulna/diagnostic imaging , Ulna/pathology
13.
Phys Med ; 29(5): 549-55, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23517667

ABSTRACT

The purpose of this study was to compare effective and ovarian doses (E and OD, respectively) in hysterosalpingography (HSG) examinations performed with conventional posterioanterior (PA) projections and rotational 3D (3D) techniques. 29 HSG examinations (11 conventional and 18 3D), were performed using a digital C-arm angiographic system. In the conventional technique, we used posterioanterior (PA) instead of an anterioposterior (AP) projection normally used according to the international literature. All information concerning exposure conditions for each patient, were recorded. Thermoluminescent dosimeters (TLDs) were attached on the skin of each patient over the ovaries. In conventional HSGs, average values were for Dose Area Product (DAP) 0.41 Gycm(2), for Effective Dose (E) 0.15 mSv and for Ovarian Dose (OD) 0.24 mGy. In 3D-HSGs, they were 14.4 Gycm(2), 2.29 mSv and 3.96 mGy correspondingly. Patient doses in 3D-HSGs are of the same order of magnitude with those reported in the literature for conventional technique. However, they are larger compared to the conventional HSG performed with the technique we use in this specific X-ray system. E and OD are much lower with our technique where PA projection and the specific C-arm system are used in comparison with the corresponding values published in the literature for the conventional technique where the AP projection is used.


Subject(s)
Hysterosalpingography/methods , Imaging, Three-Dimensional/methods , Ovary/radiation effects , Radiation Dosage , Rotation , Calibration , Female , Humans , Phantoms, Imaging
14.
Vasa ; 41(4): 295-300, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22825865

ABSTRACT

Patients with juxtarenal aneurysms require complex surgical open repair, which is associated with increased mortality and morbidity. An alternative procedure that can be used is the "chimney graft" technique. Three cases of abdominal aortic aneurysms were successfully treated in our department with this technique. One type-Ia endoleak occurred which was successfully treated with coiling and biological glue infusion. All of the chimney grafts have remained patent for the period of observation. The "chimney" technique has good results as a bail out procedure in complex EVAR or in well planned difficult cases. Long-term data is necessary to determine the efficacy of this technique.


Subject(s)
Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis Implantation/methods , Endovascular Procedures/methods , Renal Artery/surgery , Aged , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortography/methods , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/instrumentation , Embolization, Therapeutic , Endoleak/etiology , Endoleak/therapy , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Humans , Male , Middle Aged , Prosthesis Design , Renal Artery/diagnostic imaging , Stents , Tissue Adhesives/therapeutic use , Tomography, X-Ray Computed , Treatment Outcome
16.
Eur J Vasc Endovasc Surg ; 43(6): 627-31, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22487782

ABSTRACT

OBJECTIVES/DESIGN: The aim of the study was to investigate debris captured in filter embolic protection devices (EPDs) during carotid artery stenting (CAS) and its possible correlation with plaque echogenicity and other risk factors. MATERIALS/METHODS: Between June 2010 and March 2011, 51 consecutive CAS patients (11 females, mean age 71.2 ± 7, 10 symptomatic) who underwent 53 procedures were included in this prospective study. Ultrasonographic Gray-Weale plaque type (I-V, echolucent to echogenic) characterisation was obtained in all cases. The same type of stent and filter EPD was used. Filters were collected and, after macroscopic evaluation, they were examined using the Thin-Prep(®) liquid-based cytology (LBC) technique. RESULTS: Technical success was 100%. Thirty-day stroke and death rates were 1.8% (1/53) and 0%, respectively. Visible debris was detected in eight (15%) filters, whereas LBC revealed the presence of embolic material particles in 30 filters (56.6%). The presence of embolic material into the filter EPD was 2.38-fold increased for every category change from type IV to type I carotid plaques (OR = 2.38, 95%CI = 1.15-4.93). This association remained robust even after adjustment for age, gender and known atherosclerotic disease risk factors (OR = 2.26, 95%CI = 1.02-5.02). In multivariate analysis for risk factors, hypertension was associated with increased presence of embolic material detection in filter EPD (OR = 20.4, 95%CI = 1.28-326.1). The time distance from symptom to CAS was inversely correlated with debris quantity in EPD (Spearman rho -0.716; p = 0.02). CONCLUSIONS: Echolucent plaques, smaller time frame from last symptom and hypertension were associated with increased presence of embolic material.


Subject(s)
Angioplasty/instrumentation , Carotid Stenosis/therapy , Embolic Protection Devices , Embolism/prevention & control , Plaque, Atherosclerotic/therapy , Stents , Aged , Angioplasty/adverse effects , Asymptomatic Diseases , Carotid Stenosis/complications , Carotid Stenosis/diagnostic imaging , Carotid Stenosis/mortality , Chi-Square Distribution , Embolism/etiology , Embolism/mortality , Embolism/pathology , Female , Greece , Humans , Hypertension/complications , Logistic Models , Male , Middle Aged , Odds Ratio , Plaque, Atherosclerotic/complications , Plaque, Atherosclerotic/diagnostic imaging , Plaque, Atherosclerotic/mortality , Prospective Studies , Risk Assessment , Risk Factors , Stroke/etiology , Stroke/prevention & control , Time Factors , Treatment Outcome , Ultrasonography
17.
Cardiovasc Intervent Radiol ; 35(5): 1145-53, 2012 Oct.
Article in English | MEDLINE | ID: mdl-21870208

ABSTRACT

PURPOSE: To illustrate quantitative discomanometry's (QD) diagnostic efficacy and predictive value in discogenic-pain evaluation in a prospective study correlating intradiscal pressure values with pain reduction after percutaneous image-guided technique (i.e., percutaneous decompression, PD). MATERIALS AND METHODS: During the last 3 years, 36 patients [21 male and 15 female (mean age 36 ± 5.8 years)] with intervertebral disc hernia underwent QD before PD. Under absolute sterilization and fluoroscopy, a mixture of contrast medium and normal saline (3:1 ratio) was injected. A discmonitor performed a constant rate injection and recorded pressure and volume values, thus producing the relative pressure-volume curve. PD was then performed. Pain reduction and improved mobility were recorded at 3, 12, and 24 months after PD using clinical evaluation and a numeric visual scale (NVS; 0 to 10 units). RESULTS: Mean pain values of 7.5 ± 1.9 (range 4 to 8) NVS units were recorded before PD; these decreased to 2.9 ± 2.44 at 3 months, 1.0 ± 1.9 at 12 months, and 1.0 ± 1.9 NVS units at 24 months after PD. Recorded correlations (pressure, volume, significant pain-reduction values) with bilateral statistical significance included a maximum injected volume of 2.4 ml (p = 0.045), P (o) < 14 psi [initial pressure required to inject 0.1 ml of the mixture inside the disc (p = 0.05)], P (max) ≤ 65 psi [greatest pressure value on the curve (p = 0.018)], and P (max) - P (o) ≤ 47 psi (p = 0.038). Patients meeting these pressure or volume cut-off points, either independently or as a total, had significant pain reduction (>4 NVS units) after PD. No complications were noted. CONCLUSIONS: QD is an efficient technique that may have predictive value for discogenic pain evaluation. It might serve as a useful tool for patient selection for intervertebral disc therapies.


Subject(s)
Diskectomy, Percutaneous/methods , Intervertebral Disc Displacement/physiopathology , Intervertebral Disc Displacement/surgery , Manometry/methods , Adolescent , Adult , Chi-Square Distribution , Decompression, Surgical , Female , Fluoroscopy , Humans , Male , Middle Aged , Pain Measurement , Prospective Studies , Treatment Outcome
18.
Br J Radiol ; 84(997): 70-7, 2011 Jan.
Article in English | MEDLINE | ID: mdl-21172967

ABSTRACT

OBJECTIVES: The aim of this study was to determine occupational dose levels in interventional radiology and cardiology procedures. METHODS: The study covered a sample of 25 procedures and monitored occupational dose for all laboratory personnel. Each individual wore eight thermoluminescent dosemeters next to the eyes, wrists, fingers and legs during each procedure. Radiation protection shields used in each procedure were recorded. RESULTS: The highest doses per procedure were recorded for interventionists at the left wrist (average 485 µSv, maximum 5239 µSv) and left finger (average 324 µSv, maximum 2877 µSv), whereas lower doses were recorded for the legs (average 124 µSv, maximum 1959 µSv) and the eyes (average 64 µSv, maximum 1129 µSv). Doses to the assisting nurses during the intervention were considerably lower; the highest doses were recorded at the wrists (average 26 µSv, maximum 41 µSv) and legs (average 18 µSv, maximum 22 µSv), whereas doses to the eyes were minimal (average 4 µSv, maximum 16 µSv). Occupational doses normalised to kerma area product (KAP) ranged from 11.9 to 117.3 µSv/1000 cGy cm² and KAP was poorly correlated to the interventionists' extremity doses. CONCLUSION: Calculation of the dose burden for interventionists considering the actual number of procedures performed annually revealed that dose limits for the extremities and the lenses of the eyes were not exceeded. However, there are cases in which high doses have been recorded and this can lead to exceeding the dose limits when bad practices are followed and the radiation protection tools are not properly used.


Subject(s)
Extremities/radiation effects , Occupational Exposure/prevention & control , Radiation Protection/standards , Radiology, Interventional , Female , Humans , Male , Medical Staff, Hospital , Radiation Dosage , Radiology, Interventional/methods
19.
J Cardiovasc Surg (Torino) ; 51(4): 533-8, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20671636

ABSTRACT

The field of endovascular abdominal aortic repair has changed remarkably compared to what it was prior to 1993, the year of the first commercial endograft deployment in the United States. Over the years of endovascular aneurysm repair experience, various companies have attempted to construct an ideal stent-graft for exclusion of an abdominal aortic aneurysm (AAA). However, it has become evident that not all abdominal aortic anatomies are amenable to endovascular treatment and that the rationale "one device fits all AAAs" can lead to disastrous results. Different endografts have dissimilar properties and characteristics. Type of graft material, configuration and type of stent structural support, modularity, type of transrenal fixation, are potentially influential factors of endograft behavior. The self-expanding E-vita abdominal stent-graft (JOTEC, Hechingen, Germany) is a relatively new infrarenal, modular stent-graft with suprarenal fixation designed for AAA reconstruction. The present paper analyzes the technical characteristics and properties of this device. We also analyze our experience with the endoprosthesis and review the current literature.


Subject(s)
Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis , Endovascular Procedures/instrumentation , Stents , Aged , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortography , Blood Vessel Prosthesis Implantation/adverse effects , Endoleak/etiology , Endovascular Procedures/adverse effects , Graft Occlusion, Vascular/etiology , Humans , Male , Prosthesis Design , Treatment Outcome
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