[Morphological changes in the vestibular analyzer in the dynamics of an experimental disorder of the cerebral circulation]. / Morfologicheskie izmeneniia vestibuliarnogo analizatora v dinamike éksperimental'nogo narusheniia mozgovogo krovoobrashcheniia.

The alterations of microcirculatory structures and of neurons as a result of chronic cerebrovascular disturbances induced by ligation of the left common carotid artery were studied on 56 noninbred white male rats. The objects of investigation were central links of vestibular analyser such as anterior vestibular nucleus, posterior ventro-lateral part of hypothalamus, sensomotor brain cortex. It was established that one-sided ligation of common carotid artery resulted in alterations in vessels of microcirculatory bed, in neurons' bodies, in synapses. These disorders were similar to oxygen-deficient damages, described in literature which confirm the model's adequacy. These alterations appeared in different time and had various degree of expression in different structures. The latter observation may reflect different phylogenetic age of the structures studied. The reaction of the neuronal population as the functional system was observed as the process of alterations of the correlation of neurons with different functional activity. This process had periodic pattern.

[The place of vascular pathology among suicide risk factors]. / Mesto sosudistoi patologii v faktorakh riska zavershennykh suitsidov.

A study was made of the structure and intensity of vascular pathology in persons with completed suicides. The relation of that pathology to other risk factors was established as was the correlation between vascular pathology in different organs together with its role as a risk factor of suicides. Based on the data obtained, the system of medicosocial security of elderly patients is proposed in order to prevent suicides.

[The pathomorphological changes in the epiphysis in chronic alcoholism]. / Patomorfologicheskie izmeneniia épifiza pri khronicheskom alkogolizme.

Routine, histochemical and morphometric methods were used in examination of epiphyses in 45 autopsy cases of persons that suffered of alcoholism. Characteristic morphofunctional features of the epiphysis were found in those suffering from alcoholism with a stable and hard drinking character, alcohol epilepsy showing involvement of the epiphysis in the complex pathogenesis of the disease.

[Endocrine function of the epiphysis in disorders of cerebral circulation (morphological study)]. / Endokrinnaia funktsiia épifiza pri narusheniiakh mozgovogo krovoobrashcheniia (morfologicheskoe issledovanie).

In a quantitative morphological study of the epiphyses from 56 patients whose death was related to various types of cerebral circulation disorders the authors have specified the characteristics of the endocrine function of this organ in each of the pathological types studied, with the status of the merocrine and "emergency" holocrine secretion of the epiphysis being assessed separately. The authors consider the possible significance of the identified epiphysis dysfunction in the development and course of cerebrovascular diseases and outline possible types of involvement of the epiphysis in their pathogenesis.

[Biogenic monoamines and their precursors in rats with spontaneous arterial hypertension]. / Biogennye monoaminy i ikh predshestvenniki u krys so spontannoi arterial'noi gipertenziei.

Content of tryptophane, tyrosine, serotonin, noradrenaline, adrenaline and dopamine was studied in blood serum and various brain regions of rats with genetically determined spontaneous form of hypertension. The arterial pressure of these animals was shown to depend on activity of noradrenaline-, serotonin- and dopaminergic systems of brain. Oppositely directed alterations in content of dopamine and noradrenaline were observed in various brain regions apparently as a result of changes in activity of the enzymes involved in the amines synthesis and degradation.

[Spectrofluorimetric study of interaction between acetylcholine and brain proteins]. / Spektrofluorimetricheskoe iccledovanie vzaimodeistviia atsetilkholina s belkami mozga.

Interaction of acetyl-choline in 10(-4) . 10(-12) M concentration with a water-soluble fraction of homogenates of different brain areas (medulla oblongata, pons varolii, sensomotor cortex, dorsal and ventral hippocamp, hypothalamus, amygdaloid nuclei region and septal region) was studied by the spectrofluorimetric method. Fluorescence complexes spectra at excitation wavelength of 280, 296 nm were investigated. It is shown that the ACH addition to the water-soluble fractions results in reduction of the spectrum intensity and in insignificant shift of the fluorescence maxima to a short-wave region. This effect is supposed to be due to ACH interaction with the cholinoreceptor (CHR). The number of CHR in all the brain regions studied is calculated. Good correlation is observed between the regional distribution of CHR and the acetylcholinesterase activity.

[Morphologo-histochemical characteristics of ischemic cerebral infarcts in the acute stage of the stroke in patients with atherosclerosis]. / Morfologo-gistokhimicheskaia kharakteristika ishemicheskikh infarktov mozga v ostroi stadii insul'ta u bol'nykh aterosklerozom.

Morphological and histochemical investigations of the activity of succinate, malate, lactate, isocitrate, and glucoso-6-phosphate dehydrogenases, and NAD-diaphorase in the central, marginal, borderline and perifocal zones of ischemic brain infarctions were carried out. Deep changes in the activity of the enzymes listed, and peculiarities of this activity in various brain structures and tissues were revealed. A connection between the activity of the enzymes, the duration of the infarction, and the structural and biochemical peculiarities of the affected brain part is demonstrated. A suggestion is made on the pathogenesis of the ischemic infarctions and on the possibility of using histochemical data for the purposes of the pathoanatomic diagnosis.