Stemless total shoulder arthroplasty using a novel multiplanar osteotomy and elliptical humeral head results in both improved early range of motion and radiographic center of rotation compared with standard total shoulder arthroplasty.

BACKGROUND: Restoration of the native glenohumeral anatomy is an important consideration in obtaining optimal range of motion (ROM) after anatomic total shoulder arthroplasty (TSA). Recently, a new stemless TSA system has been developed that uses both a multiplanar osteotomy (MPO), to improve the surgeon's ability to restore humeral center of rotation (COR), and an elliptical humeral head to improve ROM. The purpose of our study was to compare the difference in early postoperative ROM and restoration of radiographic COR, between this stemless TSA and standard stemmed TSAs. METHODS: This was a retrospective review of 50 consecutive primary TSAs performed by a single surgeon for glenohumeral osteoarthritis. The initial cohort underwent TSA with a standard stemmed humeral component with a circular humeral head (n = 25), whereas the subsequent cohort underwent stemless TSA using an MPO and an elliptical humeral head (n = 25). Postoperative data collection included active shoulder ROM as measured by goniometer, complications or revision surgery, and measurements of radiographic COR. Patients were assessed at 6 weeks, 12 weeks, 6 months, and 12 months after surgery. Change in COR was determined on postoperative radiographs by 2 fellowship-trained surgeons on 2 separate occasions. Intra- and interrater reliability were computed using intraclass correlation coefficients. RESULTS: For both mean forward flexion (FF) and external rotation (ER), there was greater ROM in the MPO-elliptical group at all time points, which was statistically significant. Mean change in FF favored the MPO group at 6 and 12 weeks and was statistically significant and above the minimal clinically important difference (MCID): 6 weeks, standard -15.8° vs. MPO 8.4° (P = .004); 12 weeks, standard 6.4° vs. MPO 29.2° (P = .001). Mean change in ER favored the MPO group at 6 weeks and was statistically significant: standard 5.4° vs. MPO 14.0° (P = .02). There were no revision surgeries in either group. Average change in COR was 2.7 mm in the standard group and 1.8 mm in the MPO-elliptical group, which was statistically significant (P < .001). Number of patients with >3 mm of difference in COR was 10 (40%) in the standard group and 1 (5%) in the MPO-elliptical group, which was statistically significant (P = .002). Average intraclass correlation coefficient was 0.75, indicating good reliability within and between surgeon measurements. CONCLUSION: The use of a multiplanar osteotomy and elliptical humeral head was associated with improved early range of motion and better reproduction of the radiographic COR compared with standard stemmed TSA.

What do positive and negative Cutibacterium culture results in periprosthetic shoulder infection mean? A multi-institutional control study.

BACKGROUND: Deep tissue culture specimens obtained at the time of revision shoulder arthroplasty are commonly positive for Cutibacterium. Clinical interpretation of positive cultures can be difficult. This was a multi-institutional study evaluating the accuracy of cultures for Cutibacterium using positive control (PC) and negative control (NC) samples. The relationship between time to culture positivity and strength of culture positivity was also studied. METHODS: Eleven different institutions were each sent 12 blinded samples (10 PC and 2 NC samples). The 10 PC samples included 2 sets of 5 different dilutions of a Cutibacterium isolate from a failed total shoulder arthroplasty with a probable periprosthetic infection. At each institution, the samples were handled as if they were received from the operating room. Specimen growth, time to culture positivity, and strength of culture positivity (based on semiquantitative assessment) were reported. RESULTS: A total of 110 PC samples and 22 NC samples were tested. One hundred percent of specimens at the 4 highest dilutions were positive for Cutibacterium. At the lowest dilution, 91% of samples showed positive findings. Cutibacterium grew in 14% of NC samples. Cutibacterium grew in PC samples at an average of 4.0 ± 1.3 days, and all of these samples showed growth within 7 days. The time to positivity was significantly shorter (P < .001) and the strength of positivity was significantly higher (P < .001) in true-positive cultures compared with false-positive cultures. CONCLUSIONS: This multi-institutional study suggests that different institutions may report highly consistent rates of culture positivity for revision shoulder arthroplasty samples with higher bacterial loads. In contrast, with lower bacterial loads, the results are somewhat less consistent. Clinicians should consider using a shorter time to positivity and a higher strength of positivity as adjuncts in determining whether a tissue culture sample is a true positive.

Surgical Management of Pectoralis Major Tears of the Sternal Origin Because of Seat Belt Trauma: A Report of 2 Cases.

CASES: Two patients presented with medial chest pain and deformity after high-speed motor vehicle accidents (MVAs) in which they were restrained drivers. Physical examination revealed retraction of the pectoralis major from the sternum on resisted adduction and internal rotation of the arm. MRI confirmed tears of the pectoralis major from the sternal origin. Both patients underwent delayed surgical repair with excellent results. CONCLUSION: Tears of the pectoralis major at the sternal origin are rare injuries that can result in significant deformity and pain. Surgical repair, even in a delayed fashion, can result in excellent patient outcomes.

The In Vitro Efficacy of Doxycycline over Vancomycin and Penicillin in the Elimination of Cutibacterium Acnes Biofilm.

Cutibacterium acnes (formerly Propionibacterium acnes) is a significant pathogen in periprosthetic joint infections (PJIs) in total shoulder arthroplasty. Poor outcomes seen in PJIs are due to the established C. acnes bacterial biofilms. The prolonged nature of C. acnes infections makes them difficult to treat with antibiotics. The goal of this study was to determine the relative efficacy of vancomycin compared with penicillin and doxycycline against planktonic and mature biofilms. Clinical isolates from PJI patients as well as a laboratory strain of C. acnes were tested. Planktonic minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were obtained using modified clinical laboratory standard index assays. Biofilm MICs and MBCs were also obtained. The MIC was determined for both using the PrestoBlue viability stain. The MBC was determined using differential reinforced clostridial medium agar plates for colony-forming unit analysis. Using the PrestoBlue viability reagent, the planktonic MIC values for vancomycin were significantly higher than doxycycline. Across 10 strains of C. acnes, all three antibiotics had decreased efficacy when comparing planktonic and biofilm cultures. Although effective antibiotic doses ranged from 1 to 1,000 µg/mL, only doxycycline achieved inhibitory and bactericidal concentrations in all tested strains. Penicillin failed to achieve the minimum biofilm inhibitory concentration (MBIC) in 60% of tested strains, whereas vancomycin failed in 80% of tested strains. Penicillin, doxycycline, and vancomycin have similar abilities in inhibiting C. acnes growth planktonically. The MBIC for doxycycline was within the clinical dosing range, suggesting C. acnes biofilm offers minimal tolerance to these antibiotics. The MBIC for penicillin was within clinical dosing ranges in only 60% of trials, suggesting the relative tolerance of C. acnes to penicillin. The minimum biofilm bactericidal concentration (MBBC) of doxycycline showed efficacy in 90% of trials, whereas penicillin and vancomycin achieved MBBC in 15% of samples.

Wear rates of highly cross-linked polyethylene humeral liners subjected to alternating cycles of glenohumeral flexion and abduction.

BACKGROUND: Although short-term outcomes of reverse total shoulder arthroplasty have been promising, long-term success may be limited due to device-specific complications, including scapular notching. Scapular notching has been explained primarily as mechanical erosion; however, the generation of wear debris may lead to further biologic changes contributing to the severity of scapular notching. METHODS: A 12-station hip simulator was converted to a reverse total shoulder arthroplasty wear simulator subjecting conventional and highly cross-linked ultra-high-molecular-weight polyethylene humeral liners to 5 million cycles of alternating abduction-adduction and flexion-extension loading profiles. RESULTS: Highly cross-linked polyethylene liners (36.5 ± 10.0 mm(3)/million cycle) exhibited significantly lower volumetric wear rates compared with conventional polyethylene liners (83.6 ± 20.6 mm(3)/million cycle; P < .001). The flexion-extension loading profile exhibited significantly higher wear rates for conventional (P < .001) and highly cross-linked polyethylene (P < .001) compared with the abduction-adduction loading profile. Highly cross-linked wear particles had an equivalent circle diameter significantly smaller than wear particles from conventional polyethylene (P < .001). CONCLUSIONS: Highly cross-linked polyethylene liners significantly reduced polyethylene wear and subsequent particle generation. More favorable wear properties with the use of highly cross-linked polyethylene may lead to increased device longevity and fewer complications but must be weighed against the effect of reduced mechanical properties.

Clinical and radiographic results of cementless reverse total shoulder arthroplasty: a comparative study with 2 to 5 years of follow-up.

BACKGROUND: Most studies of reverse total shoulder arthroplasty (RTSA) involve cemented humeral stems. To our knowledge, this is the first study to compare the results of cementless RTSA, using a porous-coated stem designed for uncemented fixation, with cemented RTSA. METHODS: A prospective database of patients undergoing RTSA was retrospectively reviewed for patients with a diagnosis of cuff tear arthropathy or severe rotator cuff deficiency with minimum 2-year follow-up. Of these, 37 patients had cemented RTSA and 64 patients had cementless RTSA. Outcome measures included Constant-Murley scores, American Shoulder and Elbow Surgeons scores, visual analog pain scale scores, range of motion, patient satisfaction, and radiographic evidence of complication. RESULTS: Compared with preoperative values, both cohorts demonstrated significant improvements (P < .01) in all functional scores, active forward elevation, and active internal rotation. There was no significant difference (P > .05) in comparing the changes in these values after surgery between the cemented and cementless cohorts. On radiographic evaluation, there was no evidence of loosening or humeral components "at risk" of loosening in either group. There was no significant difference (P = 1.0) in the incidence of humeral component radiolucent lines between the cemented and uncemented cohorts. There was no significant difference (P = .30) in the incidence of scapular notching between the cemented (n = 8) and uncemented (n = 10) cohorts. CONCLUSION: Cementless fixation of a porous-coated RTSA humeral stem provides clinical and radiographic outcomes equivalent to those of cemented stems at minimum 2-year follow-up. With advantages such as simplified operative technique, no cement-related complications, greater ease of revision, and long-lasting biologic fixation, uncemented fixation may provide several benefits over cemented fixation.

Biomechanical testing of small versus large lesser tuberosity osteotomies: effect on gap formation and ultimate failure load.

BACKGROUND: Subscapularis muscle dysfunction after total shoulder arthroplasty (TSA) can be a devastating complication. Recent biomechanical and clinical results suggest the superiority of lesser tuberosity osteotomy (LTO) over subscapularis tenotomy; however, disagreement over the best repair technique remains. This study aimed to characterize the strength of 2 novel repair techniques for LTO fixation compared with standard tenotomy and dual-row tuberosity osteotomies during TSA. METHODS: Twenty fresh frozen cadaveric shoulders were dissected of all soft tissues except the humeri and attached subscapularis myotendinous unit. Humeri and subscapularis muscle belly were secured to a materials testing frame and subjected to cyclic loading, followed by load to failure for characterization of gap formation, ultimate failure load, and mechanism of failure. Repair techniques investigated were traditional subscapularis tenotomy and dual-row fleck LTO compared with novel techniques of single-cable and 2-suture large LTO repairs. RESULTS: No significant difference in ultimate failure load was noted among the repair techniques (P = .565). The tenotomy repair (6.0 ± 3.9 mm) displayed significantly greater gapping in response to increasing load than LTO repair techniques (P < .05). No significant difference was noted between any LTO repairs at specific loads during cyclic testing (P > .05). CONCLUSION: Our study displayed superior repair integrity of LTO vs tenotomy repairs. The advantages of the 2-suture large LTO technique over other LTO techniques include its simple technique, with a minimum amount of suture, avoidance of metallic hardware, and greater access to the glenoid, while providing comparable repair stability. Further research is warranted to fully evaluate these new techniques.

Results of total shoulder arthroplasty with a monoblock porous tantalum glenoid component: a prospective minimum 2-year follow-up study.

BACKGROUND: Aseptic loosening of all-polyethylene glenoid components remains a limiting factor in achieving long-term implant survival in total shoulder arthroplasty (TSA). This study prospectively evaluated the functional and radiographic outcomes of patients undergoing TSA with a novel, porous, tantalum-backed glenoid component, with a minimum 2 years of follow-up. MATERIALS AND METHODS: Porous tantalum-backed glenoid components were used in 19 TSAs in 19 patients. All patients were available for radiographic follow-up at an average of 38 months (range, 24-64 months). Patients were evaluated prospectively using the American Shoulder and Elbow Surgeons (ASES) score and pain on a visual analog scale (VAS). Radiographs were evaluated for component loosening and failure of the porous tantalum backing at a minimum 2 years of follow-up. RESULTS: The mean VAS decreased from 8.6 to 2.9 (P < .0001). The mean ASES score improved from 21 to 70 points (P < .05). Mean active forward elevation improved from 75° to 131° (P < .0001). At latest follow-up, all glenoid components except 1 had complete in-growth of the porous tantalum keel; however, 4 components (21%) failed by fracture at the keel-glenoid face junction. CONCLUSIONS: There was an unacceptably high rate of glenoid component failure (21%) due to fracture at the keel-glenoid face junction in this series. The manufacturer has subsequently revised this early design to reduce the risk of failure. The results of this study illustrate that caution should be exercised in the use of novel implants with an unproven clinical track record.

A biomechanical analysis of initial fixation options for porous-tantalum-backed glenoid components.

BACKGROUND: Porous-tantalum (PT)-backed glenoid components have recently been developed to improve fixation and minimize the incidence of glenoid component loosening, which remains a key limiting factor in long-term survival in total shoulder arthroplasty. PT-backed glenoids promote bony ingrowth as a method of preventing glenoid loosening at the prosthesis-glenoid interface. The use of polymethyl-methacrylate (PMMA) cement for initial fixation may prevent osteointegration due to mechanical occlusion of the porous surface and the nonosteoconductive properties of PMMA. This study aims to investigate alternative fixation methods of PT-backed glenoids in a biomechanical investigation. MATERIALS AND METHODS: Nine PT-backed monoblock glenoid components were implanted in a polyurethane bone substitute using either press-fit, PMMA cement, or calcium phosphate cement techniques. A control group of 3 all-polyethylene pegged glenoid components was implanted with PMMA. Glenoid and humeral head components were fixed to a biomechanical testing machine for testing according to ASTM Standard F-2028. The humeral head was translated ±1.5 mm along the superior-inferior axis for 50,000 cycles for characterization of glenoid rocking and inferior-superior translation. RESULTS: Glenoid compression and glenoid distraction followed similar patterns for PT-backed glenoids. Overall, the all-polyethylene cemented glenoid demonstrated superior fixation compared to all PT-backed groups throughout the test. Glenoids fixed with PMMA cement displayed more favorable initial fixation and resistance to glenoid motion throughout cyclic testing. CONCLUSION: This study showed that among PT-backed glenoids, PMMA fixation provided an increase in stability during initial and final cycles compared to press-fit and calcium-phosphate fixation techniques. This improved stability may enhance the osteointegration of the implant.

Reverse total shoulder arthroplasty for the management of failed shoulder arthroplasty with proximal humeral bone loss: is allograft augmentation necessary?

BACKGROUND: Patients undergoing revision shoulder arthroplasty frequently have deficient proximal humeral bone stock. Proximal humeral allograft has been recommended to augment reverse total shoulder arthroplasty (RTSA) to improve stability and function. This study reports the results of RTSA without proximal humeral allograft in patients with proximal humeral bone loss secondary to failed shoulder arthroplasty. MATERIALS AND METHODS: From 2005 to 2008, 251 patients were enrolled in a prospective RTSA cohort study. Significant humeral bone loss was demonstrated in 15 of 56 undergoing revision for failed arthroplasty. Average age was 67 years. Average bone loss measured 38.4 mm (range, 26-72 mm). Patients were followed up for a minimum of 2 years with American Shoulder and Elbow Surgeons (ASES), Subjective Shoulder Value (SSV), Constant Score (CS), and visual analog scale (VAS) pain scores, as well as self-reported satisfaction and radiographs. RESULTS: Patients demonstrated significant improvement in mean CS (23.0 to 44.2), ASES (38.2 to 68.3), ASES activities of daily living (7.0 to 15.9), SSV (19.2 to 75.8), and VAS pain (4.6 to 1.6) scores. Thirteen of 15 patients reported satisfaction (87%). Range of motion improved in forward flexion (38.3° to 103.2°) and external rotation (-0.5° to 11.9°). Radiographs demonstrated notching in 3 patients (20%), no humeral subsidence or loosening, and prosthetic fracture of 1 modular humeral stem. CONCLUSIONS: Use of RTSA for failed shoulder arthroplasty and deficient humeral bone stock provides a significant clinical benefit without the need for allograft augmentation. Monoblock humeral component use may diminish risk for prosthetic fracture.

Comparison of standard two-dimensional and three-dimensional corrected glenoid version measurements.

HYPOTHESIS: There is concern regarding the accuracy of 2-dimensional (2D) computed tomography (CT) for measuring glenoid version. Three-dimensional (3D) CT scan reconstructions can properly orient the glenoid to the plane of the scapula and have been reported to accurately measure glenoid version in cadaver models. We hypothesized that glenoid version measured by correcting 2D CT scans to the plane of the scapula by 3D reconstruction would be significantly different compared with standard 2D CT scan measurement of the glenoid in a clinical patient population. MATERIALS AND METHODS: Thirty-four patients underwent dedicated axial 2D CT scan of the shoulder with 3D reconstruction. The 2D glenoid version was measured on unmodified midglenoid axial cuts, and the 3D glenoid version measurement was corrected to be perpendicular to the plane of the scapula and then measured in the axial plane. Three observers repeated each measurement on 2 different days. RESULTS: The difference between the overall average 2D and 3D measurements was not statistically significant (P = .45). In individual scapulae, 35% of 2D measurements were 5° to 10° different and 12% were greater than 10° different from their corresponding 3D-corrected CT measurement (P < .001 to P = .045). Reproducibility of both 2D and 3D-corrected measurements was good. DISCUSSION: Although 2D and 3D corrected methods showed a high degree of both intraobserver and interobserver reliability in this series, axial 2D images without correction were 5 to 15 degrees different than their 3D-corrected counterparts in 47% of all measurements. Correcting 2D glenoid version by 3D reconstruction to the transverse plane perpendicular to the scapular body allows for an accurate assessment of glenoid version in spite of positioning differences and results in increased accuracy while maintaining high reliability. CONCLUSIONS: Owing to the variability in scapular position, the axial 2D CT scan measurement was significantly different from 3D-corrected measurement of glenoid version. Averaging the version measurements across patients did not reflect this finding.