ABSTRACT
Ageing induces a decline in GABAergic intracortical inhibition, which seems to be associated not only with decremental changes in well-being, sleep quality, cognition and pain management but also with impaired motor control. So far, little is known regarding whether targeted interventions can prevent the decline of intracortical inhibition in the primary motor cortex in the elderly. Therefore, the present study investigated whether age-related cortical dis-inhibition could be reversed after 6 months of balance learning and whether improvements in postural control correlated with the extent of reversed dis-inhibition. The results demonstrated that intracortical inhibition can be upregulated in elderly subjects after long-term balance learning and revealed a correlation between changes in balance performance and intracortical inhibition. This is the first study to show physical activity-related upregulation of GABAergic inhibition in a population with chronic dis-inhibition and may therefore be seminal for many pathologies in which the equilibrium between inhibitory and excitatory neurotransmitters is disturbed. KEY POINTS: Ageing induces a decline in GABAergic intracortical inhibition. So far, little is known regarding whether targeted interventions can prevent the decline of intracortical inhibition in the primary motor cortex in the elderly. After 6 months of balance learning, intracortical inhibition can be upregulated in elderly subjects. The results of this study also revealed a correlation between changes in balance performance and intracortical inhibition. This is the first study to show physical activity-related upregulation of GABAergic inhibition in a population with chronic dis-inhibition.
Subject(s)
Aging , Learning , Motor Cortex , Postural Balance , Humans , Male , Aged , Postural Balance/physiology , Motor Cortex/physiology , Female , Aging/physiology , Learning/physiology , Neural Inhibition , Middle Aged , GABAergic Neurons/physiology , Adult , Transcranial Magnetic Stimulation , gamma-Aminobutyric Acid/metabolism , Evoked Potentials, MotorABSTRACT
Augmented feedback (aF) positively influences motor performance by enhancing motivation and/or by providing information about task execution. It was speculated that aF-induced performance increments that rely on motivation should also occur when providing incorrect aF, while performance increments that rely on guidance towards "successful executions" (i.e. improved performances) should only occur when aF is correct. We further hypothesised that the informational content of aF is more important in more complex motor tasks. Thus, 32 participants received two forms of aF (correct, incorrect) during maximal voluntary contractions (MVC's; maximise force without time constraints; less complex) and maximal explosive contractions (MEC's; maximise force in the shortest possible way; more complex) of the knee extensors. Peak torque (MVC), peak rate of torque development (MEC) and EMG signals of rectus femoris (RF) and vastus lateralis were recorded. Correct and incorrect aF significantly enhanced MVC performance, indicating that performance improvements resulted mainly from the motivational property of aF. The observed trend towards increased RF muscle activity supports this conclusion. In contrast, while correct aF positively impacted MEC performance, incorrect aF had a negative influence. This indicates that the informational property of aF guided participants towards movement executions resulting in improved (correct aF) or decreased (incorrect aF) performances. The observed simultaneous decrease in muscle activity suggests that participants changed motor strategy, supporting the guiding role of aF. Our results demonstrate that the motivational aspect of aF dominates in maximal tasks with lower complexity (MVC), while the informational aspect is used during more complex maximal tasks (MEC).
Augmented feedback (aF) can influence performance by enhancing the motivation and/or by providing information about the execution of a task.Our results demonstrate that over the short-term, the motivational aspect of aF dominates in maximal tasks with lower complexity (maximal voluntary contractions). In contrast, the informational aspect will predominantly be used during more complex maximal tasks (maximal explosive contractions).This is the first study distinguishing between the motivational and informational aspects of aF during maximal motor tasks. Future research should focus on the long-term effects of these two separate aspects of aF.