A METHOD FOR IMPROVING THE PROFESSIONAL PERFORMANCE AND RELIABILITY OF PERSONS DRIVING HIGH-SPEED VEHICLES.

Recently, due to the emergence of a variety of modifications of air, land, water vehicles and an increase in their speed and maneuverability, the number of people with severe manifestations of motion sickness has also increased. The relevance of this problem is dictated by the fact that, despite significant achievements in the field of preventive medicine, a significant number of people prone to motion sickness have been observed to date. Thus, among persons using land modes of transport, the percentage of sick people reaches 15.0%, air modes 20.0%, while using water modes of transport, the number of sick people reaches 30.0%. The significance of this problem is dictated by the fact that the psycho-physiological capabilities of our body do not keep pace with the rapidly increasing speed-maneuvering characteristics of vehicles.

[The combined use of peptide bioregulators and self-massage in order to improve the psychophysiological state and increase the professional performance of the elderly.]

The development of modern society is characterized by an increase in the volume and changing forms of information presentation. In the works of Russian and foreign gerontologists, it is noted that the perception and analysis of the flow of relevant data today causes difficulties for a significant part of citizens of older age groups, which is due, among other things, to the deterioration of their psychophysiological state. The lack of the ability to use the necessary information negatively affects the quality of life, the level of social adaptation and professional competence. This problem is particularly significant for population groups and professional communities, whose life and activities require the actualization of certain sectors of the information field. Typical examples of such groups are citizens of retirement age who continue professional activities related to the mobilization of intellectual and creative potential, in particular, university teachers. The use of gerontotechnologies contributes to solving the problem, which provides for the development of effective methods for correcting the functional state of elderly citizens, in particular, increasing the ability to perceive information and the level of vital activity. This publication presents the results of an experimental study of the effectiveness of the combined use of peptide bioregulators and massage on the level of professional performance of elderly teachers of a pedagogical university.

[Accelerated aging as a risk of the education digitalization: possibilities for prevention.]

The work is devoted to the analysis of the education digitalization negative effects and the possibilities of their prevention consideration. The urgency of this problem in the modern conditions of combating the pandemic of the new coronavirus infection and moving a significant part of education and leisure to the virtual space is noted. Against the background of a deficit in physical activity and an increase in the information consumption duration, the participants in the experiment showed a significant increase in the frequency of mental and physical maladjustment symptoms occurrence, a decrease in performance indicators and a deterioration in the biological age parameters. The geroprotective effect of correcting the student lifestyle with an emphasis on information hygiene, optimizing sleep, rest, motor and nutritional regimen in terms of qualitative and quantitative indicators is shown.

DRUG DEVELOPMENT BY IN SILICO METHODS.

Multicenter studies of the last decade have confirmed the direct relationship between the spatial structure of drug compounds and their biological activity. Aim - the relevance of this topic, on the one hand, is explained by the rapid development of new technologies, on the other hand, by a large number of researches works devoted to the study of the influence of stereoisomeric factors on the therapeutic effect and side effects of drugs. In recent decades, computational approaches have been used to reveal the relationship between the biological properties of substances and their structure and to quantitatively describe this relationship. Quantitative Structure - Activity Relationships (QSAR) is widely used in modern drug chemistry. In combination with molecular modeling techniques, this trend has been commonly referred to as in silico methods, which implies a preliminary search for drugs by computer only, prior to experimental screening. Hundreds of QSAR and molecular modeling programs have been developed around the world: dozens of specialized scientific journals are published dedicated to computer-based methods of searching for biologically active substances. Thousands of articles have been published demonstrating the results of successful application of QSAR methods in the search for new biologically active substances. There are currently more than 101 million known organic compounds in the world, and the known number of biological activities exceeds 25,000, so global experimental testing of all substances is impossible. Thus, the use of in silico methods to search for drugs, in particular, for the preliminary selection of unpromising compounds is super relevant.

[Working ability of elderly university teachers under the combined influence of breathing exercises and peptide bioregulator «Cortexin¼.]

The two-week use of special breathing exercises in combination with the Cortexin peptide bioregulator optimizes the functional state and increases the professional performance of older teachers more effectively compared to the single use of a pharmacological preparation. The maximum effect is noted immediately after the end of the course use of special breathing exercises and the peptide bioregulator and lasts for two months. The results obtained open up prospects for the use of breathing exercises to enhance and prolong the nootropic drugs and antihypoxants antistress and geroprotective effects.

[The influence of self-massage combined with drug Noopept on the professional performance of teachers older.]

It is shown that the two-week use of self-massage of the head and neck in combination with the pharmacological drug Noopept improves the functional state and increases the professional performance of elderly teachers compared to single use of nootropic drug. The greatest increase in the functional state and professional performance was noted immediately after the course of self-massage of the head and neck in combination with the pharmacological drug Noopept. The combined effect of self-massage and nootropic drug on the functional state and professional performance indicators are maintained for 1-2 months, and by the end of the third month they are approaching the initial values.

[Modern means of statokinetic improvement and vestibular rehabilitation].

The article presents the results of studying the effectiveness of the complex vestibular workouts based on non-invasive neuromodulation technology in 37 healthy patients aged 18-20 years who have symptoms of aerial sickness in 5 or less minutes. Non-invasive neuromodulation wire-familiarize with the apparatus for vestibular rehabilitation "Brain-Port" (USA), performing electric tactile stimulation of the tongue with biofeedback. An indicator of statokinetic stability was considered from time to tolerance to the vestibular load up to development of vegetative manifestations of aerial sickness. 'Improvement of statokinetic tolerability vestibular training confirmed by computed posturography and gait analysis. Increase of statokinetic stability accompanied not only by an increase in exposure, necessary for motion sickness, but also a decrease in autonomic manifestations, which are the main obstacle to the operator's military activities. Improving balance and gait performance after the swipe-of vestibular training course demonstrates the possible realization of two mechanisms of compensatory and restorative processes: sensory substitution equilibrium function and induction of neuroplasticity in short time.

[The pathogenetic approach to the development of tools and methods for the improvement of statokinetic stability in the operators of aerospace systems].

The objective of the present study was to estimate the efficacy of the tools and methods for the optimization of the activity of the central nervous system (CNS) and analyzers involved in the maintenance of the statokinetic (SK) stability in man. To this effect, we evaluated the outcome of bemitil treatment during 10 days with and without A.I. Yarotsky test and the influence of these procedures on the pathophysiological characteristics of selected elements of the work of operators of aerospace systems. Based on the data obtained in the study, the tools and methods have been developed that allow the efficacy and quality of certain aspects of the operators' activity to be improved, viz. general working capacity under conditions requiring enhanced statokinetic stability, self-confidence, emotional and somatic comfort.

[The effect of training flights on the level of statokinetic resistance in the aviation cadets of foreign armies]. / Vliianie uchebno-trenirovochnykh poletov na uroven' statokineticheskoi ustoichivosti kursantov inostrannykh armii.

The article studies the influence of training flight upon the statokinetic resistance of cadets from foreign countries. It was found out that in the process of flight training the level of statokinetic resistance was growing, and simultaneously the vegetative, sensor and somatic manifestations were decreasing, and the period of stable equilibration in N.N. Bondarevskii test was increasing. The most pronounced changes in statokinetic resistance was marked in the cadets from Mozambique, Mongolia and Angola; the smallest--in cadets from Vietnam and Laos. In order to optimize the flight training of cadets and safety of training flights it is recommended to apply the system of complex medical monitoring, which will realize the control over the psychophysiological state and statokinetic resistance during the whole period of training.