Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions.

Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are otherwise healthy. The overgrowth in OPDKD affects body parts that typically have lower temperature than 37°C. We present evidence that OPDKD is associated with a temperature sensitive, activating substitution, p.(Asn666Tyr), in PDGFRB. Phosphorylation levels of PDGFRB and downstream targets were higher in OPDKD fibroblasts at 37°C but were further greatly increased at the average corneal temperature of 32°C. This suggests that the substitution cause significant constitutive autoactivation mainly at lower temperature. In contrast, a different substitution in the same codon, p.(Asn666Ser), is associated with Penttinen type of premature aging syndrome. This devastating condition is characterized by widespread tissue degeneration, including pronounced chronic ulcers and osteolytic resorption in distal limbs. In Penttinen syndrome fibroblasts, equal and high levels of phosphorylated PDGFRB was present at both 32°C and 37°C. This indicates that this substitution causes severe constitutive autoactivation of PDGFRB regardless of temperature. In line with this, most downstream targets were not affected by lower temperature. However, STAT1, important for tissue wasting, did show further increased phosphorylation at 32°C. Temperature-dependent autoactivation offers an explanation to the strikingly different clinical outcomes of substitutions in the Asn666 codon of PDGFRB.

Accidental exposure to electromagnetic fields from the radar of a naval ship: a descriptive study.

Part of a crew on a Norwegian naval ship was exposed to the radar waves for approximately 7 min from an American destroyer during an incident at sea in August 2012. Information about the exposure was not given by the navy. This is a description of what happened with the crew on board after this event. 14 persons had been on the ship bridge or outside on the deck during the exposure and the rest of the crew had been inside the ship. 27 persons were examined at a hospital 6-8 months after the event, as they had developeda large number of symptoms from different organ systems. They were very worried about all types of possible adverse health effects due to the incident. All were examined by an occupational physician and anophthalmologist, by an interview, clinical examinations and blood tests at the hospital. The interview of the personnel revealed that they had not experienced any major heating during the episode. Their symptoms developed days or weeks after the radar exposure. They had no objective signs of adverse health effects at the examination related to the incident. Long-term health effect from the exposure is highly unlikely. The development of different symptoms after the incident was probably due to the fear of possible health consequences. Better routines for such incidents at sea should be developed to avoid this type of anxiety.

The activity on a Norwegian Occupational Health mailing list 1997-2006.

BACKGROUND: Professional mailing lists on the Internet have become a popular medium for communication in the medical field. There are few descriptions of the scientific activity on these mailing lists and none concerning occupational health have been found. AIM: To describe the activity of an occupational health electronic mailing list in Norway between 1997 and 2006. METHODS: All messages sent to the Norwegian Occupational Health mailing list from 1997 to 2006 were studied, counting numbers, members and type of topic discussed. The job titles of contributors in 2006 were identified and all messages in a 3-month period in 2006 were analysed in more detail. RESULTS: A total of 5269 messages were posted to the list. The number of members was 200 at the start of 1997, later rising to between 450 and 500, including doctors, physiotherapists, occupational hygienists and nurses. The main topics discussed were chemical hazards (19%), organization of occupational health services (17%), working methods in health and safety in general (10%) and ergonomics (8%). Most messages were questions and answers and they seldom led to discussion. CONCLUSIONS: The activity shows the need for electronic mailing communication in occupational health services. A broad range of topics was covered and most professional disciplines in occupational health services were represented. The quality of the content and usefulness of the discussions need further investigation.

Mandatory use of eye protection prevents eye injuries in the metal industry.

BACKGROUND: Eyes are frequently injured in occupational accidents. What is the preventive effect of mandatory eye protection in metalworking? METHODS: The injury incidence was determined before and after eye protection became mandatory in a metalworking yard. RESULTS: The incidence declined from 6.09 to 0.42 injuries per million working hours after eye protection became mandatory. CONCLUSIONS: Mandatory eye protection among metalworkers in Norway has high potential for preventing eye injuries and should be implemented.

[Can work-related eye injuries be avoided?]. / Kan arbeidsrelaterte øyeskader unngås?

BACKGROUND: The eyes are among the organs most frequently hurt in occupational injuries. The characteristics of eye injuries were studied in order to suggest preventive measures. MATERIAL AND METHODS: Analyses were performed on work-related eye injuries reported to the Norwegian Injury Surveillance System from a selection of emergency centres during the period 1990-2002, and on injuries reported by employers to the National Insurance Administration 1998-2001. RESULTS: The occurrence of injuries was stable over the period. Men sustained 94.4% of the injuries registered in injury surveillance system. The highest incidence was among those 20 to 24 years of age. Metal cutters and tools for polishing were involved in 25.7% of cases. Analyses of the injuries reported to the National Insurance Administration showed an odds ratio of 8.8 (95% CI 7.6-10.1) for injuries to workers in metal industry, 18.8 (95% CI 17.0-20.8) in automotive industry, and only 0.5 (95% CI 0.1-3.4) in oil refineries. Workers in oil refineries have a potentially hazardous work environment, but there, eye protection is mandatory. INTERPRETATION: There was no decline in the incidence of work-related eye injuries from 1990 to 2002. Workers in metal industry have a high risk of injuries and employers should consider requiring the use of eye protection.