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1.
Eur Heart J ; 44(30): 2805-2814, 2023 08 07.
Article in English | MEDLINE | ID: mdl-37264699

ABSTRACT

The colorful term "coronary steal" arose in 1967 to parallel "subclavian steal" coined in an anonymous 1961 editorial. In both instances, the word "steal" described flow reversal in the setting of an interconnected but abnormal vascular network-in one case a left subclavian stenosis proximal to the origin of the vertebral artery and in the other case a coronary fistula. Over time, the term has morphed to include a larger set of pathophysiology without explicit flow reversal but rather with a decrease in stress flow due to other mechanisms. This review aims to shed light on this phenomenon from a clinical and a pathophysiological perspective, detailing the anatomical and physiological conditions that allow so-called steal to appear and offering treatment options for six distinct scenarios.


Subject(s)
Coronary Artery Disease , Coronary-Subclavian Steal Syndrome , Subclavian Steal Syndrome , Humans , Vertebral Artery , Heart
2.
J Neurosurg Anesthesiol ; 31(2): 218-226, 2019 Apr.
Article in English | MEDLINE | ID: mdl-29782389

ABSTRACT

BACKGROUND: Preexisting cognitive impairment in surgical patients is one of the leading risk factors for adverse cognitive outcomes such as postoperative delirium and postoperative cognitive dysfunction. We developed a self-administered tablet computer application intended to assess the individual risk for adverse postoperative cognitive outcomes. This cross-sectional study aimed to establish normative data for the tool. MATERIALS AND METHODS: Healthy volunteers aged 65 years and above were administered the Mini-Mental State Examination, Geriatric Depression Scale, and Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery to assess cognitive health. All subjects completed the tablet computer application without assistance. Primary outcome measure was the test performance. Regression models were built for each cognitive domain score with the covariates age, sex, and education in cognitively healthy subjects. Demographically adjusted standard scores (z-scores) were computed for each subtest. RESULTS: A total of 283 participants (155 women, 128 men) were included in the final analysis. Participants' age was 73.8±5.2 years (mean±SD) and their level of education was 13.6±2.9 years. Mini-Mental State Examination score was 29.2±0.9 points, Geriatric Depression Scale score was 0.4±0.7 points, and Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery total score was 98.7±5.7 points. Older age was associated with poorer performance in the visual recognition task and in Trail Making Test B (P<0.05 after Bonferroni-Holm adjustments). CONCLUSIONS: This study provides normative data for a novel self-administered tablet computer application that is ultimately designed to measure the individual risk for adverse postoperative cognitive outcomes in elderly patients.


Subject(s)
Cognition Disorders/diagnosis , Cognition , Neuropsychological Tests , Age Factors , Aged , Aged, 80 and over , Alzheimer Disease/psychology , Cognition Disorders/etiology , Cognition Disorders/psychology , Cross-Sectional Studies , Delirium/etiology , Delirium/psychology , Depression/diagnosis , Depression/psychology , Female , Geriatric Assessment , Healthy Volunteers , Humans , Male , Mental Status and Dementia Tests , Postoperative Complications/psychology , Reference Values , Trail Making Test
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