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Synthesis and pharmacological evaluation of a series of analgesic and antiinflammatory 4-aminopyrroles.
Tarzia, G; Panzone, G; Leali, M; Burdisso, M; Schiatti, P; Selva, D.
Farmaco Sci ; 39(6): 538-58, 1984 Jun.
Article in English | MEDLINE | ID: mdl-6432578

ABSTRACT

The synthesis and the pharmacological evaluation of a series of analgesic, antiinflammatory beta-aminopyrroles is described. Qualitative structure activity relationships are discussed. One of the compounds reported in the study is a candidate for toxicological and clinical trials.


Subject(s)
Analgesics/chemical synthesis , Anti-Inflammatory Agents/chemical synthesis , Pyrroles/chemical synthesis , Animals , Arachidonic Acid , Arachidonic Acids/antagonists & inhibitors , Arthritis, Experimental/drug therapy , Carrageenan , Chemical Phenomena , Chemistry , Diarrhea/drug therapy , Edema/drug therapy , Lethal Dose 50 , Male , Pyrroles/pharmacology , Rats , Rats, Inbred Strains , Structure-Activity Relationship , Ulcer/chemically induced
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