1.
Monatsh Chem
; 148(1): 63-68, 2017.
Article
in English
| MEDLINE
| ID: mdl-28127092
ABSTRACT
ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH4-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents.