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Inflamm Res ; 71(1): 131-140, 2022 Jan.
Article in English | MEDLINE | ID: mdl-34850243

ABSTRACT

OBJECTIVES: The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27- IgD- B cells in COVID-19 patients, representing a group of atypical and neglected subpopulations of this cell lineage. METHODS: Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis. RESULTS: We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups. CONCLUSION: This study provides insights into DN B cell subsets' potential role in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.


Subject(s)
COVID-19/blood , COVID-19/immunology , Immunoglobulin D/blood , SARS-CoV-2 , Tumor Necrosis Factor Receptor Superfamily, Member 7/blood , Adult , Aged , Aged, 80 and over , B-Lymphocytes/cytology , COVID-19/diagnosis , COVID-19/virology , Cell Lineage , Computational Biology , Disease Progression , Female , Humans , Male , Middle Aged , Principal Component Analysis , Prognosis , Respiration, Artificial , Severity of Illness Index , Young Adult
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