ABSTRACT
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Subject(s)
Male , Middle Aged , Humans , Vocal Cord Paralysis/etiology , Myasthenia Gravis/complications , Myasthenia Gravis/diagnosisABSTRACT
A case of severe miastenia beginning with dyspnea, secondary to a bilateral larynx paralysis in aduction is presented. During the evolution of the severe miastenia the affectation of the larynx musculature does not result infrequent, but however, after having realized a bibliographic revision, the infrequency resulting in this disease of the beginning through a bilateral larynx paralysis in aduction was verified. A wide exposition of the clinic case, methods of exploration to obtain the diagnosis of severe miastenia, and the different treatment options actually in use to control these disease, are realized.
Subject(s)
Myasthenia Gravis/complications , Respiratory Sounds/etiology , Vocal Cord Paralysis/complications , Humans , Male , Middle Aged , Vocal Cord Paralysis/etiologyABSTRACT
A severe adverse drug effect secondary to allopurinol ingestion has been described, characterized by fever, eosinophilia, cutaneous rash, hepatic lesion and renal failure, with a high mortality (21-26%) and unknown ethiopathogenicity. In many cases patients had a previous disorder on their renal function (53%) and more than half received allopurinol due to asymptomatic hyperuricemia. We present two new cases and review other 18 patients diagnosed in the last nine years, analyzing the ethiopathogenicity, epidemiological, clinical, therapeutical and preventive aspects.
Subject(s)
Allopurinol/adverse effects , Drug Hypersensitivity/etiology , Aged , Drug Hypersensitivity/pathology , Female , Humans , Male , Middle AgedABSTRACT
BACKGROUND: Cerebrovascular disease has particular features in young adults (15-45 years). In this context, non-traumatic intracranial hematoma (NTICH) has received little attention. Therefore, its analysis has been attempted focusing on etiology, localization and short term prognosis. METHODS: 42 patients aged 15-45 years who were admitted because of NTICH were evaluated. 41 variables were analyzed with chi-square method and Fischer's exact test. RESULTS: The localization of hematoma was as follows: basal ganglia/thalamus in 59%, lobar in 19%, posterior fossa in 12%, pure intraventricular in 2 cases and multiple in one case. The most common etiology was hypertension (HT) (32%), followed by arteriovenous malformations (12%), oral anticoagulants (10%), chronic alcohol abuse (10%), coagulation disorders and one central nervous system arteriopathy; 12 cases were idiopathic. On the basis of etiology two groups were distinguished: 15-30 years (no case with hypertension) and 30-45 years (HT as the leading cause). Survival was 89%. CONCLUSIONS: NTICH in young adults has a heterogeneous etiology. On the basis of the most common cause two groups can be considered: from 15 to 30 years (arteriovenous malformation) and from 30 to 45 years (HT). High blood pressure at the time of stroke is correlated with previous HT. The short term life prognosis is better than that of NTICH in general series. Deterioration of consciousness in the acute phase and oral anticoagulation are poor prognostic factors.