Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence.

BACKGROUND: Stimulant use and sexual behaviors have been linked in behavioral and epidemiological studies. Although methamphetamine-related neurofunctional differences have been investigated, few studies have examined neural responses to drug and sexual cues with respect to shorter or longer term methamphetamine abstinence in individuals with methamphetamine dependence. METHODS: Forty-nine men with shorter term methamphetamine abstinence, 50 men with longer term methamphetamine abstinence, and 47 non-drug-using healthy comparison men completed a functional magnetic resonance imaging cue-reactivity task consisting of methamphetamine, sexual, and neutral visual cues. RESULTS: Region-of-interest analyses revealed greater methamphetamine cue-related activation in shorter term methamphetamine abstinence and longer term methamphetamine abstinence individuals relative to healthy comparison men in the ventromedial prefrontal cortex. A significant interaction of group and condition in the anterior insula was found. Relative to healthy comparison participants, both shorter term methamphetamine abstinence and longer term methamphetamine abstinence groups displayed greater sexual cue-related anterior insula activation relative to methamphetamine cues and neutral cues, but there were no differences between shorter term methamphetamine abstinence and longer term methamphetamine abstinence groups in anterior insula responses. Subsequent whole-brain analyses indicated a group-by-condition interaction with longer term methamphetamine abstinence participants showing greater sexual-related activation in the left superior frontal cortex relative to healthy comparison men. Shorter term methamphetamine abstinence participants showed greater superior frontal cortex activation to sexual relative to neutral cues, and longer term methamphetamine abstinence participants showed greater superior frontal cortex activation to sexual relative to neutral and methamphetamine cues. CONCLUSIONS: The findings suggest that abstinence from methamphetamine may alter how individuals respond to drug and sexual cues and thus may influence drug use and sexual behaviors. Given the use of methamphetamine for sexual purposes and responses to natural vs drug rewards for addiction recovery, the findings may have particular clinical relevance.

Factorial validity of a substance-use stigma scale in methamphetamine-using adults in China.

BACKGROUND: Despite the large number of individuals who use substances of abuse and the stigma of such behaviors in China, scales have not been developed and validated for assessing substance-use stigma. Given its importance for targeting interventions, the aim of the present study was to validate a Chinese substance-use stigma measure including three dimensions of substance-use-disorder-related stigma (personal stigma, perceived stigma and social distance) by modifying a pre-existing scale measuring mental illness-related stigma and social distance. METHODS: A convenience sample of eight-hundred-and-twelve individuals with substance abuse (aged 18-68 years) from different drug rehabilitation centers completed a self-reported survey including their demographics and drug use, and the stigma and social distance scales. The adapted, translated from English to Chinese, and back-translated scales were an 18-items stigma scale including personal stigma and perceived stigma subscales and a 5-items one domain social distance scale. Confirmatory factor analysis and multigroup confirmatory factor analysis tested factorial validity and measurement invariance of the scales, respectively. RESULTS: For the stigma scale, by deleting one low correlation dimension (named "weak-not-sick"), personal stigma and perceived stigma showed acceptable fit indices and internal consistency with two dimensions (named "dangerous/unpredictable" and "social discrimination"), separately. The social distance scale showed good fit indices and internal consistency as a separate facet of stigma-related substance-use problems. Invariance of the model across drug-rehabilitation centers was found. CONCLUSIONS: The Chinese substance-use stigma scale may serve as a valuable tool for better understanding substance-use stigma among adults in China who abuse substances.