[The nimodipine therapy of acute focal cerebral ischemia (minor stroke). A clinical study with an assessment of regional cerebral blood flow by SPECT]. / Terapia con nimodipina dell'ischemia cerebrale acuta a focolaio (minor stroke). Studio clinico con valutazione del flusso cerebrale regionale tramite SPECT.

Aim of the study is the evaluation of therapeutic effectiveness of nimodipine in acute focal cerebral ischaemia. Thirty patients affected by minor ischaemic stroke divided in two randomized groups have been studied consecutively: all the patients were treated with standard therapy, nimodipine was delivered in addition only to the patients of the first group. Both clinical evaluation using Mathew scale, modified by Gelmers, and flowmetric evaluation with SPECT were performed at different times. The results haven't shown any significant statistical difference in the effectiveness of the therapy between the two groups even if a positive clinical trend was evidenced in the group treated with nimodipine. The flowmetric study has shown the poor homogeneity of the groups from a physiopathological point of view not-with-standing the two groups were similar for the clinical severity, sex, age and vascular risk factors. We conclude that is advisable to carry out further trials in which the comparison study groups are more numerous and balanced also from a physiopathological point of view.

[The patient with carotid reversible cerebral ischemic attack. Clinico-instrumental pathogenetic diagnosis]. / Il paziente con attacco ischemico cerebrale reversible (RIA) carotideo. Diagnosi patogenetica clinico-strumentale.

Reversible ischemic attacks (RIA) in the carotid territory may be caused by different pathogenetic diseases (atheroembolism, cardioembolism, lacunar infarcts, hemodynamics crisis); peculiar therapeutic treatment has to be related to each pathophysiologic evidence. A pathogenetical and diagnostical approach based on clinical and instrumental data is suggested by the Authors; by this way it was possible to obtain a right pathogenetic diagnosis in 82% of a 144 patients series affected by carotid RIA.

[Platelet aggregation inhibitory therapy in chronic arterial occlusive disease of the lower limbs: results of short-term clinico-instrumental study with indobufen]. / La terapia antiaggregante piastrinica nelle arteriopatie obliteranti croniche degli arti inferiori: risultati di uno studio clinico-strumentale a breve termin con indobufene.

Aim of our study was to evaluate the effectiveness of indobufen in the treatment of II degree stage lower limb occlusive arterial disease. Forty patients were randomly assigned to the iIndobufen (400 mg/die) treatment group or the no treatment control group (20 patients each). Doppler pressure measurement (Winsor index) and subjective symptomatology were evaluated at the time of enrollment and after one month. A significant improvement (p less than 0.01) was noted only in the treated group. We conclude that indobufen may be of therapeutic value in the treatment of peripheral occlusive arterial disease.