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Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.

Rendón-Ochoa, Ernesto Alberto; Padilla-Orozco, Montserrat; Calderon, Vladimir Melesio; Avilés-Rosas, Victor Hugo; Hernández-González, Omar; Hernández-Flores, Teresa; Perez-Ramirez, María Belén; Palomero-Rivero, Marcela; Galarraga, Elvira; Bargas, José.

ASN Neuro ; 14: 17590914221102075, 2022.

Article in English | MEDLINE | ID: mdl-36050845

ABSTRACT

SUMMARY STATEMENT: A2A receptor required previous D2 receptor activation to modulate Ca2+ currents. Istradefylline decreases pramipexole modulation on Ca2+ currents. Istradefylline reduces A2A + neurons activity in striatial microcircuit, but pramipexole failed to further reduce neuronal activity.

Subject(s)

Dopamine , Parkinsonian Disorders , Adenosine , Animals , Parkinsonian Disorders/drug therapy , Pramipexole , Receptors, Dopamine D2/physiology , Rodentia

ABSTRACT

Subject(s)

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