1.
J Am Chem Soc
; 143(11): 4187-4192, 2021 03 24.
Article
in English
| MEDLINE
| ID: mdl-33689345
ABSTRACT
The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals and late stage C-H oxidation to incorporate the C7' alcohol.