Relationship between intended force and actual force: comparison between athletes and non-athletes.

This cross-sectional study aimed to investigate whether athletes (ATHL) and non-athletes (NON-ATHL) individuals had similar accuracy in matching intended to actual force during ballistic (BAL) and tonic (TON) isometric contractions. In this cross-sectional study, the subjects were divided into ATHL (n = 20; 22.4 ± 2.3 yrs; 73.2 ± 15.7 kg; 1.76 ± 0.08 m) and NON-ATHL (n = 20; 24.6 ± 2.4 yrs; 68.2 ± 15.0 kg; 1.73 ± 0.1 m) groups. The isometric quadriceps strength was measured with a load cell applied to a custom-built chair. For each condition, subjects performed at first three maximal voluntary isometric contractions (MVIC) as reference. Then, subjects had to match three intended force intensities expressed in percentage of the MVIC (i.e., 25%, 50%, and 75%) without any external feedback. Subjects performed three trials for each force intensity. The accuracy (AC) was calculated as the absolute difference in percentage between the intended and the actual force. A Likert scale was administered for each trial to assess the subjective matching between the intended and the actual force. Statistical analysis showed that the ATHL group was more accurate (p < 0.001) than the NON-ATHL group. In contrast, the AC (p < 0.001) was lower when the force intensities increased independently from the group. Moreover, significantly higher AC (p < 0.001) and lower aggregate Likert scores (p < 0.001) were found in BAL than TON conditions. These results suggest that (i) sports practice could enhance muscle recruitment strategies by increasing the AC in the isometric task; (ii) differences between intended and actual force appeared to be intensity-dependent with lower AC at high force intensities; (iii) different control systems act in modulating BAL and TON contractions.

Thinking about it: the impact of COVID-19-related stimuli on prospective memory.

Background: Since 2020, information regarding COVID-19 has been a constant presence in the news, in our conversations and thoughts. Continuous exposure to this type of stimuli could have an impact on cognitive processes essential for our everyday activities, such as prospective memory (PM). PM is the ability to remember to perform an intention at a specific point in the future, like remembering to take prescribed medicines at a specific time or to turn off the stove after cooking. Do COVID-related stimuli affect our ability to perform a PM task? Methods: To answer this question, we proposed a novel version of the classical paradigm used to investigate PM. Namely, this paradigm includes a baseline condition, in which an ongoing task is presented alone, and a PM condition in which the same task is proposed again together with a second (prospective) task. In this study, a short video clip was presented between the baseline and the PM condition. The video clip displayed either neutral, negative, or COVID-related content. Additionally, participants were asked to respond to two questionnaires and a series of questions regarding their well-being and experience with the pandemic. Namely, the DASS-21 scale (evaluating depression, anxiety, and stress), and the COVID-19-PTSD questionnaire (a questionnaire evaluating post-traumatic stress disorder symptoms related to the pandemic experience) were administered. Participants' performance and responses were analyzed using a linear mixed effect (LME) model approach, and correlation analyses were run to highlight possible correlations between participants' scores in the DASS-21, the COVID-19-PTSD, and the additional questions on their personal experience with the pandemic. Results: The LME models revealed significant effects of the displayed video on performance: in line with previous studies, the clip displaying standard negative contents led to impaired accuracy in the ongoing task in the PM condition, compared to the Baseline. In contrast, participants who saw the COVID-related clip showed improved accuracy in the ongoing task compared to the other participants, selectively in the block performed after the video clip was displayed (PM condition). Furthermore, the explanatory power of the LME model calculated on accuracy to the ongoing trials was enhanced by the inclusion of the scores in the anxiety subscale of the DASS-21, suggesting a detrimental role of anxiety. Altogether, these results indicate a different effect of the exposure to classical negative contents (associated with a cost in terms of accuracy in the ongoing task between the baseline and the PM condition) and the pandemic-related one, which was instead characterized by a higher accuracy to ongoing trials compared to the other video clips. This counterintuitive finding seems to suggest that COVID-related stimuli are processed as "acute stressors" rather than negative stimuli, thus inducing a state of increased alertness and responsivity.

Young adults and multisensory time perception: Visual and auditory pathways in comparison.

The brain continuously encodes information about time, but how sensorial channels interact to achieve a stable representation of such ubiquitous information still needs to be determined. According to recent research, children show a potential interference in multisensory conditions, leading to a trade-off between two senses (sight and audition) when considering time-perception tasks. This study aimed to examine how healthy young adults behave when performing a time-perception task. In Experiment 1, we tested the effects of temporary sensory deprivation on both visual and auditory senses in a group of young adults. In Experiment 2, we compared the temporal performances of young adults in the auditory modality with those of two samples of children (sighted and sighted but blindfolded) selected from a previous study. Statistically significant results emerged when comparing the two pathways: young adults overestimated and showed a higher sensitivity to time in the auditory modality compared to the visual modality. Restricting visual and auditory input did not affect their time sensitivity. Moreover, children were more accurate at estimating time than young adults after a transient visual deprivation. This implies that as we mature, sensory deprivation does not constitute a benefit to time perception, and supports the hypothesis of a calibration process between senses with age. However, more research is needed to determine how this calibration process affects the developmental trajectories of time perception.

Time bisection and reproduction: Evidence for a slowdown of the internal clock in right brain damaged patients.

Previous studies show that the right hemisphere is involved in time processing, and that damage to the right hemisphere is associated with a tendency to perceive time intervals as shorter than they are, and to reproduce time intervals as longer than they are. Whether time processing deficits following right hemisphere damage are related and what is their neurocognitive basis is unclear. In this study, right brain damaged (RBD) patients, left brain damaged (LBD) patients, and healthy controls underwent a time bisection task and a time reproduction task involving time intervals varying between each other by milliseconds (short durations) or seconds (long durations). The results show that in the time bisection task RBD patients underestimated time intervals compared to LBD patients and healthy controls, while they reproduced time intervals as longer than they are. Time underestimation and over-reproduction in RBD patients applied to short but not long time intervals, and were correlated. Voxel-based lesion-symptom mapping (VLSM) showed that time underestimation was associated with lesions to a right cortico-subcortical network involving the insula and inferior frontal gyrus. A small portion of this network was also associated with time over-reproduction. Our findings are consistent with a slowdown of an 'internal clock' timing mechanism following right brain damage, which likely underlies both the underestimation and the over-reproduction of time intervals, and their (overlapping) neural bases.

The role of posterior parietal cortex and medial prefrontal cortex in distraction and mind-wandering.

Distraction reflects a drift of attention away from the task at hand towards task-irrelevant external or internal information (mind-wandering). The right posterior parietal cortex (PPC) and the medial prefrontal cortex (mPFC) are known to mediate attention to external information and mind-wandering, respectively, but it is not clear whether they support each process selectively or rather they play similar roles in supporting both. In this study, participants performed a visual search task including salient color singleton distractors before and after receiving cathodal (inhibitory) transcranial direct current stimulation (tDCS) to the right PPC, the mPFC, or sham tDCS. Thought probes assessed the intensity and contents of mind-wandering during visual search. The results show that tDCS to the right PPC but not mPFC reduced the attentional capture by the singleton distractor during visual search. tDCS to both mPFC and PPC reduced mind-wandering, but only tDCS to the mPFC specifically reduced future-oriented mind-wandering. These results suggest that the right PPC and mPFC play a different role in directing attention towards task-irrelevant information. The PPC is involved in both external and internal distraction, possibly by mediating the disengagement of attention from the current task and its reorienting to salient information, be this a percept or a mental content (mind-wandering). By contrast, the mPFC uniquely supports mind-wandering, possibly by mediating the endogenous generation of future-oriented thoughts capable to draw attention inward, away from ongoing activities.

Controlled hypotension during middle ear surgery: hemodynamic effects of remifentanil vs nitroglycerin.

INTRODUCTION: Controlled hypotension is a well-known technique used by anesthesiologists to limit intraoperative bleeding in patients undergoing middle ear surgery and improve visibility of the surgical field. Nitroglycerin and remifentanil are among the drugs used to induce controlled hypotension.The aim of our study was to compare the hemodynamic effects of remifentanil and nitroglycerin in this patient population. METHODS: All consecutive patients who underwent middle ear surgery between January and December 2016, at the University Hospital Vittorio Emanuele in Catania were included in a retrospective study. Patients who were given nitroglycerin to induce controlled hypotension were compared to those given remifentanil. The following parameters were measured systolic and diastolic blood pressure, heart rate, peripheral (capillary) oxygen saturation, and fraction of expired carbon dioxide. A mean arterial pressure of 50-70 mmHg was considered optimal. RESULTS: Thirty patients who underwent stapedioplasty and tympanoplasty, 25 men and 5 women,with a mean age of 43 years (range 32-58 years) were included in the study. Fifteen patients had received nitroglycerin (group A) and 15 patients remifentanil (group B). The target blood pressure was reached in all patients and no significant difference was found between the groups with regard to the level of systolic and diastolic blood pressure, heart rate, peripheral (capillary) oxygen saturation, and fraction of expired carbon dioxide. However the heart rate of 2 younger patients in group A rose to > 100 bpm after the administration of nitroglycerin. CONCLUSION: Both remifentanil and nitroglycerin are effective in inducing controlled hypotension. In younger patients administration of nitroglycerin is associated with an increase in heart rate. KEY WORDS: Controlled hypotension, Middle ear surgery, Nitroglycerin, Remifentanil.