Artificial intelligence in breast imaging: Current situation and clinical challenges.

Breast cancer ranks among the most prevalent malignant tumours and is the primary contributor to cancer-related deaths in women. Breast imaging is essential for screening, diagnosis, and therapeutic surveillance. With the increasing demand for precision medicine, the heterogeneous nature of breast cancer makes it necessary to deeply mine and rationally utilize the tremendous amount of breast imaging information. With the rapid advancement of computer science, artificial intelligence (AI) has been noted to have great advantages in processing and mining of image information. Therefore, a growing number of scholars have started to focus on and research the utility of AI in breast imaging. Here, an overview of breast imaging databases and recent advances in AI research are provided, the challenges and problems in this field are discussed, and then constructive advice is further provided for ongoing scientific developments from the perspective of the National Natural Science Foundation of China.

Functional magnetic resonance imaging research in China.

Functional magnetic resonance imaging (fMRI) non-invasively measures the activity of the human brain and provides a unique technological tool for investigating aspects of the human brain including cognition, development, and disorders. As one of the main funding agencies for basic research in China, the National Natural Scientific Foundation of China (NSFC) has initiated various research programs during the last two decades that are related to fMRI research. In this review, we collected and analyzed the metadata of the projects and published studies in research fields using fMRI that were funded by the NSFC. We observed a trend of increasing funding amounts from the NSFC for fMRI research, typically from the General Program and Key Program. Leading research institutes from economically developed municipalities and provinces received the most support and formed close collaboration relationships. Finally, we reviewed several representative achievements from research institutions in china, involving data analysis methods, brain connectomes, and computational platforms in addition to their applications in brain disorders.

Stroke Research in China over the Past Decade: Analysis of NSFC Funding.

We analyzed the projects and published studies funded by NSFC (National Natural Science Foundation of China) in the field of stoke. Further more, we searched the published papers supported by NSFC in the last decade using the keywords of "stroke" or "cerebrovascular disease" and analyzed the results according to the topics associated with the mechanisms of ischemic brain injury, novel techniques and new drugs, medical imaging, translational medicine, and traditional Chinese medicine.

Current aging research in China.

The mini-review stemmed from a recent meeting on national aging research strategies in China discusses the components and challenges of aging research in China. Highlighted are the major efforts of a number of research teams, funding situations and outstanding examples of recent major research achievements. Finally, authors discuss potential targets and strategies of aging research in China.

Progress of basic research in Parkinson's disease in China: data mini-review from the National Natural Science Foundation.

This review is to analyze the role of National Natural Science Foundation of China (NSFC) on the development of basic research of Parkinson's disease from 1990 to 2012. Data on the total number of projects and funding of NSFC allocated to Parkinson's disease, as well as hotspots in western countries, papers published, awards, personnel training, subject construction were collected, and the role of NSFC on other sources of funding was evaluated. Over the past 23 years, a full range of continuous funding from NSFC has led to fruitful results and a strong impetus to the progress of basic research of Parkinson's disease.

Grand Research Plan for Neural Circuits of Emotion and Memory--current status of neural circuit studies in China.

During recent years, major advances have been made in neuroscience, i.e., asynchronous release, three-dimensional structural data sets, saliency maps, magnesium in brain research, and new functional roles of long non-coding RNAs. Especially, the development of optogenetic technology provides access to important information about relevant neural circuits by allowing the activation of specific neurons in awake mammals and directly observing the resulting behavior. The Grand Research Plan for Neural Circuits of Emotion and Memory was launched by the National Natural Science Foundation of China. It takes emotion and memory as its main objects, making the best use of cutting-edge technologies from medical science, life science and information science. In this paper, we outline the current status of neural circuit studies in China and the technologies and methodologies being applied, as well as studies related to the impairments of emotion and memory. In this phase, we are making efforts to repair the current deficiencies by making adjustments, mainly involving four aspects of core scientific issues to investigate these circuits at multiple levels. Five research directions have been taken to solve important scientific problems while the Grand Research Plan is implemented. Future research into this area will be multimodal, incorporating a range of methods and sciences into each project. Addressing these issues will ensure a bright future, major discoveries, and a higher level of treatment for all affected by debilitating brain illnesses.

An update on spinal cord injury research.

Spinal cord injury (SCI) can have a range of debilitating effects and permanently alter the capabilities and quality of life of survivors. The first specialized centers of care for SCI were established in 1944 and since then an increasing amount of research has been carried out in this area. Despite this, the present treatment and care levels for SCI are not comparable to those in other areas of medicine. In the clinic, the aim of SCI treatment is primarily to limit secondary damage by reducing compression in trauma spots and stabilizing the spinal column. Currently, no effective strategy for functional recovery is offered. In this review, we focus on research progress on the molecular mechanisms underlying SCI, and assess the treatment outcomes of SCI in animal models, i.e., neurotrophins and stem cells are discussed as pre-clinical therapies in animal models. We also assess the resources available and national research projects carried out on SCI in China in recent years, as well as making recommendations for the future allocation of funds in this area.