Factors associated with moderate sedation attendance at a university-based pediatric dental clinic.

PURPOSE/OBJECTIVES: To evaluate patient attendance for moderate sedation (MS) at a university-based pediatric dental clinic; to identify factors with negative impact on MS being completed and to assess for associations between no-show appointments and patient variables METHODS: The electronic health records of patients scheduled for MS appointments in a 22-month period were assessed by a single investigator. Demographic and clinical data related to appointment attendance and MS procedure performance were collected and statistically analyzed using chi-square, Spearman's rho correlation tests, and logistic regression (p < 0.05) RESULTS: A total of 618 scheduled MS appointments were included. The MS appointment no-show-rate was 17.1 percent. Appointment confirmation (p = 0.001) and dmft score ≥ 9 (p = 0.039) had positive correlation with attendance, while "no-shows" history (p = 0.024) and longer waiting time (p = 0.040) had negative impact on attendance. About 20% of attended MS were not completed, with main reasons of airway risk (32.3%), ongoing illness (28.4%), and violation of NPO guidelines (21.5%). Race, ethnicity, language spoken, child's behavior, and distance traveled had no significant impact on attendance CONCLUSION: Interventions to decrease non-attendance rates should target patients who are unconfirmed, have a history of no-show appointments, and are scheduled well before the sedation appointment.

Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology.

Mescaline and phencyclidine (PCP) are potent hallucinogenic agents affecting human and animal behavior. As their psychotropic effects remain poorly understood, further research is necessary to characterize phenotypes they evoke in various animal models. Zebrafish (Danio rerio) are rapidly emerging as a new model organism for neuroscience research. Here, we examine the effects of mescaline (5-20mg/l) and PCP (0.5-3mg/l) in several zebrafish paradigms, including the novel tank, open field and shoaling tests. Mescaline and PCP dose-dependently increased top activity in the novel tank test, also reducing immobility and disrupting the patterning of zebrafish swimming, as assessed by ethograms. PCP, but not mescaline, evoked circling behavior in the open field test. At the highest doses tested, mescaline markedly increased, while PCP did not affect, zebrafish shoaling behavior. Finally, 20mg/l mescaline did not alter, and 3mg/l PCP elevated, whole-body cortisol levels. Overall, our studies indicate high sensitivity of zebrafish models to hallucinogenic compounds with complex behavioral and physiological effects.