ABSTRACT
A 82-year-old man had a bulbar exophytic mass protruding through the lids and extending from the nasal side of the limbus to the caruncola in one eye. The lesion appeared 9 months before as a limbal nodule and showed a painless, slow evolution, ultimately leading to enucleation. The histopathologic examination of the neoplasm and eyeball showed an invasive squamous cell carcinoma of the conjunctiva which invaded the deep subepithelial tissue and reached the scleral surface. The evolution and pathologic features of this uncommon neoplasm were similar to that described in other cases previously reported. Such a clinical course is suggestive also of mucoepidermoid carcinoma of the conjunctiva, which closely resembles squamous cell carcinoma, but is more aggressive and locally invasive. However, after staining for mucin, this diagnosis was ruled out.
Subject(s)
Carcinoma, Squamous Cell/pathology , Conjunctival Neoplasms/pathology , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/surgery , Conjunctival Neoplasms/surgery , Eye Enucleation , Humans , Male , Neoplasm InvasivenessABSTRACT
A case of toxic epidermal necrolysis had been observed in a 4-year-old child. This patient has been reexamined by us 21 years later. At that time a biopsy of conjunctival material and a histopathologic and ultrastructural study were done. The long-term ocular complications of the disease caused severe visual impairment with a remarkable sicca syndrome due to extensive scarring and keratinization, as confirmed also by light- and electron-microscopic features. These findings, concerning a particularly long follow-up, suggest that the ocular sequelae of this disease require continuous ophthalmological supervision many years after the acute stage of the disease.
Subject(s)
Conjunctival Diseases/etiology , Stevens-Johnson Syndrome/complications , Adult , Conjunctiva/pathology , Conjunctival Diseases/pathology , Cornea/pathology , Corneal Diseases/etiology , Corneal Diseases/pathology , Humans , Male , Stevens-Johnson Syndrome/pathologyABSTRACT
The purpose of the present study was to evaluate the possible electrophysiological effects of Indoprophene, a new non steroidal analgesic anti-inflammatory agent, which might be employed in the treatment of chest-pain from myocardial ischemia. Ten patient, who were undergoing a electrophysiological study for diagnostic purposes, were given 400 mg of indoprophene by intravenous rapid bolus. The A-V conduction times were recorded in basic condition and 30 minutes after administration of the drug. The data we collected show that Indoprophene does not influences either normal or prolonged A-V conduction times. We conclude that the drug, as it has a good effect on pain and lacks haemodynamic consequences and effects on conduction and excitability, is recommendable for the treatment of chest-pain from myocardial ischemia.