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1.
J Ultrasound Med ; 32(12): 2083-9, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24277889

ABSTRACT

OBJECTIVES: The primary purpose of this study was to describe and validate a novel sonographically guided costotransverse (CTRV) joint injection technique. METHODS: The bilateral T3-T10 CTRV joints of an unembalmed cadaveric specimen were localized using a 12-3-MHz linear array transducer. A 22-gauge, 2.5-in spinal needle was directed into the CTRV joint using an in-plane, lateral-to-medial approach under direct sonographic guidance. After needle placement, 3-dimensional computed tomographic (CT) images were obtained to assess the locations of the needle tips. This step was followed by injection of an iodinated contrast agent and repeated CT to assess the contrast flow pattern. An experienced musculoskeletal radiologist reviewed the CT images and assessed the accuracy of the injections (intra- or extra-articular). For intra-articular injections, a quantitative assessment of the percentage of injectate within the joint was performed. RESULTS: A total of 16 sonographically guided CTRV joint injections were completed on a single torso-pelvis specimen. Using our technique, 11 of 16 sonographically guided CTRV joint injections (68.8%) placed the contrast agent into the target joint. Quantitative analysis of the arthrograms showed 6 of 11 intra-articular injections (54.5%) with greater than 50% injectate within the joint capsule. CONCLUSIONS: To our knowledge, this study is the first to determine the feasibility of sonographically guided CTRV joint injections. Overall, 68.8% of injection attempts produced acceptable CTRV joint arthrograms, which compares favorably to a previously reported 76% accuracy rate for fluoroscopically guided CTRV joint injections. Although these injections are technically challenging, the use of sonographic guidance to perform CTRV joint injections is feasible and warrants further investigation to establish its role in the management of patients presenting with thoracic pain syndromes.


Subject(s)
Injections, Intra-Articular/methods , Ribs/diagnostic imaging , Tomography, X-Ray Computed/methods , Ultrasonography, Interventional/methods , Zygapophyseal Joint/diagnostic imaging , Aged , Aged, 80 and over , Cadaver , Feasibility Studies , Female , Humans , Male , Reproducibility of Results , Sensitivity and Specificity , Thoracic Vertebrae/diagnostic imaging
2.
Curr Pharm Des ; 18(38): 6266-83, 2012.
Article in English | MEDLINE | ID: mdl-22762466

ABSTRACT

The operating room offers a unique setting where anesthetics, preoperative medications, patient comorbidities, and surgery all merge. Anesthesiologists are responsible for combining these concerns into a dependable and safe approach. From formulation to administration, enhancements in nearly every aspect of a given drug have improved the ability of anesthesiologists to accomplish this. Some of these methodologies, including novel anesthetics and analgesics, drug delivery and administration including infusion pumps, antithrombotics, and a reappraisal of previous medications are highlighted in this review. While these advancements are significant, patients and healthcare systems globally are rightfully demanding safer application of drugs at every level. On May 1, 2012, a report issued by the Institute of Medicine advised the United States Food and Drug Administration to undertake a much more rigorous patient-centered effort to evaluate a drug's safety over its entire life-cycle. This recommendation is in agreement with the objectives of the Anesthesia Patient Safety Foundation. With these mutual goals shared by many stakeholders and their continued efforts, the future of the estimated 200 million global surgeries to be undertaken this year hopefully provides a safer experience while under anesthesia.


Subject(s)
Adjuvants, Anesthesia/adverse effects , Analgesics/adverse effects , Anesthesia/adverse effects , Anesthetics/adverse effects , Medication Errors/prevention & control , Patient Safety , Perioperative Care/adverse effects , Adjuvants, Anesthesia/administration & dosage , Adjuvants, Anesthesia/chemistry , Analgesics/administration & dosage , Analgesics/chemistry , Anesthesia/mortality , Anesthetics/administration & dosage , Anesthetics/chemistry , Animals , Drug Delivery Systems , Drug Design , Humans , Perioperative Care/methods , Perioperative Care/mortality , Risk Assessment , Risk Factors
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