ABSTRACT
Se presentó el caso de un paciente con transplante renal, de 64 años, trabajador de una granja avícola, que sufrió una meningoencefalitis a los 6 meses de recibir tratamiento inmunosupresor. El diagnóstico rápido se realizó a partir de una muestra de líquido cefalorraquídeo mediante el empleo de partículas de látex para la detección de antígeno de Cryptococcus spp. Después se confirmó con el cultivo de la muestra clínica empleando agar-Sabouraud-cloranfenicol; la identificación bioquímica se realizó con el sistema API 20C AUX. Inmediatamente se inició el tratamiento con anfotericina B, con posterior cambio a fluconazol hasta negativizar los exámenes microbiológicos. Pasados 5 meses presentó una recaída, y se reinició el tratamiento específico. Se le dio seguimiento por consulta y presentó una evolución favorable hasta 2 años después del trasplante de órgano(AU)
This article presented the case of a 64 years-old renal transplant recipient, who was a poultry farm worker and had suffered meningoencephalitis six months after receiving immunosuppressive therapy. Rapid diagnosis was based on a cerebrospinal fluid sample analyzed with latex particles for Cryptococcus spp antigen detection. Culture of the clinical sample in agar-Sabouraund-chloramphenicol medium confirmed the initial diagnosis whereas biochemical identification was made with the API 20C AUX system. Amphotericin B treatment was immediately applied to the patient and later fluconazole until microbiological tests yielded negative results. After 5 months, the patient relapsed and restarted the specific treatment. He was followed up on outpatient service and two year after the organ transplantation, his recovery was favourable(AU)
Subject(s)
Humans , Male , Kidney Transplantation , Immunosuppressive Agents/adverse effects , Meningoencephalitis/diagnosis , Meningoencephalitis/therapyABSTRACT
Se presentó el caso de un paciente con transplante renal, de 64 años, trabajador de una granja avícola, que sufrió una meningoencefalitis a los 6 meses de recibir tratamiento inmunosupresor. El diagnóstico rápido se realizó a partir de una muestra de líquido cefalorraquídeo mediante el empleo de partículas de látex para la detección de antígeno de Cryptococcus spp. Después se confirmó con el cultivo de la muestra clínica empleando agar-Sabouraud-cloranfenicol; la identificación bioquímica se realizó con el sistema API 20C AUX. Inmediatamente se inició el tratamiento con anfotericina B, con posterior cambio a fluconazol hasta negativizar los exámenes microbiológicos. Pasados 5 meses presentó una recaída, y se reinició el tratamiento específico. Se le dio seguimiento por consulta y presentó una evolución favorable hasta 2 años después del trasplante de órgano.
This article presented the case of a 64 years-old renal transplant recipient, who was a poultry farm worker and had suffered meningoencephalitis six months after receiving immunosuppressive therapy. Rapid diagnosis was based on a cerebrospinal fluid sample analyzed with latex particles for Cryptococcus spp antigen detection. Culture of the clinical sample in agar-Sabouraund-chloramphenicol medium confirmed the initial diagnosis whereas biochemical identification was made with the API 20C AUX system. Amphotericin B treatment was immediately applied to the patient and later fluconazole until microbiological tests yielded negative results. After 5 months, the patient relapsed and restarted the specific treatment. He was followed up on outpatient service and two year after the organ transplantation, his recovery was favourable.
Subject(s)
Humans , Male , Immunosuppressive Agents/adverse effects , Kidney Transplantation , Meningoencephalitis/diagnosis , Meningoencephalitis/therapyABSTRACT
This article presented the case of a 64 years-old renal transplant recipient, who was a poultry farm worker and had suffered meningoencephalitis six months after receiving immunosuppressive therapy. Rapid diagnosis was based on a cerebrospinal fluid sample analyzed with latex particles for Cryptococcus spp antigen detection. Culture of the clinical sample in agar-Sabouraund-chloramphenicol medium confirmed the initial diagnosis whereas biochemical identification was made with the API 20C AUX system. Amphotericin B treatment was immediately applied to the patient and later fluconazole until microbiological tests yielded negative results. After 5 months, the patient relapsed and restarted the specific treatment. He was followed up on outpatient service and two year after the organ transplantation, his recovery was favourable.
