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1.
J Vet Med Sci ; 86(6): 677-683, 2024 Jun 19.
Article in English | MEDLINE | ID: mdl-38692860

ABSTRACT

Mastectomy is the standard treatment for mammary gland tumors in dogs. In addition to traditional therapy, sodium dichloroacetate (DCA) can act as target therapy, as it may promote autophagy, reduce metastatic potential, and tumor proliferation in mammary tumor cell lines. This study aimed to analyze the effects of DCA as preoperative therapy for mammary tumors in bitches. Nineteen animals were selected, and they received DCA at a dose of 10 mg/kg orally every 12 hr, for 15 days. The periodic evaluation included hematological analysis (complete blood count and biochemical markers), evaluation of gastrointestinal adverse effects, evaluation of tumor volume, histopathological analysis, and immunohistochemical evaluation (Ki67 and cyclooxygenase-2/COX-2 markers). After treatment, there was a significant reduction in hematocrit (P=0.02) and leukocyte (P=0.04) means. Despite the variations for these two hematological parameters, the means remained within the reference range for the species. There were two cases of vomiting and one case of diarrhea. Most cases were classified as carcinoma in mixed tumor (n=7, 36.8%), followed by solid carcinoma (n=6, 31.6%). Nine cases (47.4%) showed reduced tumor volume, nine (47.4%) had stable disease, and one showed progressive disease. While there was no sample with a COX-2 score higher than 6, tumor samples with COX-2 scores 3 and 4 were significantly associated with stable disease or progression. DCA preoperative treatment for bitches with mammary gland tumors showed safety and potential cytoreduction in some cases.


Subject(s)
Dichloroacetic Acid , Dog Diseases , Mammary Neoplasms, Animal , Neoadjuvant Therapy , Animals , Dogs , Female , Mammary Neoplasms, Animal/drug therapy , Mammary Neoplasms, Animal/surgery , Dog Diseases/drug therapy , Dichloroacetic Acid/therapeutic use , Neoadjuvant Therapy/veterinary
2.
Cells ; 11(4)2022 02 10.
Article in English | MEDLINE | ID: mdl-35203268

ABSTRACT

Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.


Subject(s)
Dog Diseases , Myeloproliferative Disorders , Skin Neoplasms , Animals , Dog Diseases/diagnosis , Dog Diseases/therapy , Dogs , Mast Cells/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/therapy , Skin Neoplasms/veterinary , Subcutaneous Tissue/pathology
3.
R. bras. Ci. Vet. ; 28(3): 142-145, 2021. ilus
Article in Portuguese | VETINDEX | ID: vti-765270

ABSTRACT

Os retalhos cutâneos são técnicas de escolha para reconstrução de grandes defeitos. Objetivou-se relatar o emprego do retalho de padrão axial da artéria torácica lateral em paciente com ferida cirúrgica ocasionada imediatamente após exérese de neoformação na região da articulação do cotovelo. Foi atendido paciente canino macho, 10 anos, pesando 12 kg, apresentando neoformação em tecidos moles, de grande volume, localizada na região medial do cotovelo. Como tratamento definitivo, implementou-se a exérese marginal da neoplasma seguida de reconstrução com a técnica de retalho de padrão axial da artéria torácica lateral. A técnica possibilitou completa síntese e oclusão do defeito, obtendo-se ótima recuperação pós operatória, não sendo observada deiscência de sutura ou necrose do retalho. Conclui-se que a implementação do retalho da artéria torácica lateral foi uma técnica viável na reconstrução em cotovelo após a exérese do neoplasma no paciente relatado, observando resultados satisfatórios quanto aos aspectos funcionais e cosméticos, após o período cicatricial.(AU)


Skin flaps are suitable methods of wound closure in large cutaneous defects. I The present study aims to report the use of lateral thoracic axial pattern flap to repair an elbow wound secondary to a neoplasm resection. A 10-year-old male dog weighing 12 kg was presented with a large soft tissue neoplasm in the medial aspect of the elbow. The patient underwent surgical resection of the neoplasm using the lateral thoracic cutaneous flap to achieve a complete defect closure, resulting in an excellent postoperative wound healing without suture failure or skin flap necrosis. It is concluded that the implementation of the lateral thoracic artery flap was a viable technique in elbow reconstruction after neoplasm excision in the reported patient, with satisfactory results regarding functional and cosmetic aspects after the healing period.(AU)


Subject(s)
Animals , Dogs , Free Tissue Flaps , Thoracic Arteries/injuries , Dogs/surgery
5.
Rev. bras. ciênc. vet ; 28(3): 142-145, jul./set. 2021. il.
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1363958

ABSTRACT

Os retalhos cutâneos são técnicas de escolha para reconstrução de grandes defeitos. Objetivou-se relatar o emprego do retalho de padrão axial da artéria torácica lateral em paciente com ferida cirúrgica ocasionada imediatamente após exérese de neoformação na região da articulação do cotovelo. Foi atendido paciente canino macho, 10 anos, pesando 12 kg, apresentando neoformação em tecidos moles, de grande volume, localizada na região medial do cotovelo. Como tratamento definitivo, implementou-se a exérese marginal da neoplasma seguida de reconstrução com a técnica de retalho de padrão axial da artéria torácica lateral. A técnica possibilitou completa síntese e oclusão do defeito, obtendo-se ótima recuperação pós operatória, não sendo observada deiscência de sutura ou necrose do retalho. Conclui-se que a implementação do retalho da artéria torácica lateral foi uma técnica viável na reconstrução em cotovelo após a exérese do neoplasma no paciente relatado, observando resultados satisfatórios quanto aos aspectos funcionais e cosméticos, após o período cicatricial.


Skin flaps are suitable methods of wound closure in large cutaneous defects. I The present study aims to report the use of lateral thoracic axial pattern flap to repair an elbow wound secondary to a neoplasm resection. A 10-year-old male dog weighing 12 kg was presented with a large soft tissue neoplasm in the medial aspect of the elbow. The patient underwent surgical resection of the neoplasm using the lateral thoracic cutaneous flap to achieve a complete defect closure, resulting in an excellent postoperative wound healing without suture failure or skin flap necrosis. It is concluded that the implementation of the lateral thoracic artery flap was a viable technique in elbow reconstruction after neoplasm excision in the reported patient, with satisfactory results regarding functional and cosmetic aspects after the healing period.


Subject(s)
Animals , Dogs , Soft Tissue Neoplasms/veterinary , Plastic Surgery Procedures/veterinary , Dogs/surgery , Free Tissue Flaps/veterinary , Surgery, Veterinary , Thoracic Arteries/surgery , Elbow , Surgical Wound/veterinary
6.
Rev. bras. ciênc. vet ; 28(3): 142-145, jul./set. 2021. ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1491716

ABSTRACT

Os retalhos cutâneos são técnicas de escolha para reconstrução de grandes defeitos. Objetivou-se relatar o emprego do retalho de padrão axial da artéria torácica lateral em paciente com ferida cirúrgica ocasionada imediatamente após exérese de neoformação na região da articulação do cotovelo. Foi atendido paciente canino macho, 10 anos, pesando 12 kg, apresentando neoformação em tecidos moles, de grande volume, localizada na região medial do cotovelo. Como tratamento definitivo, implementou-se a exérese marginal da neoplasma seguida de reconstrução com a técnica de retalho de padrão axial da artéria torácica lateral. A técnica possibilitou completa síntese e oclusão do defeito, obtendo-se ótima recuperação pós operatória, não sendo observada deiscência de sutura ou necrose do retalho. Conclui-se que a implementação do retalho da artéria torácica lateral foi uma técnica viável na reconstrução em cotovelo após a exérese do neoplasma no paciente relatado, observando resultados satisfatórios quanto aos aspectos funcionais e cosméticos, após o período cicatricial.


Skin flaps are suitable methods of wound closure in large cutaneous defects. I The present study aims to report the use of lateral thoracic axial pattern flap to repair an elbow wound secondary to a neoplasm resection. A 10-year-old male dog weighing 12 kg was presented with a large soft tissue neoplasm in the medial aspect of the elbow. The patient underwent surgical resection of the neoplasm using the lateral thoracic cutaneous flap to achieve a complete defect closure, resulting in an excellent postoperative wound healing without suture failure or skin flap necrosis. It is concluded that the implementation of the lateral thoracic artery flap was a viable technique in elbow reconstruction after neoplasm excision in the reported patient, with satisfactory results regarding functional and cosmetic aspects after the healing period.


Subject(s)
Animals , Dogs , Thoracic Arteries/injuries , Dogs/surgery , Free Tissue Flaps
7.
Acta sci. vet. (Online) ; 49(suppl.1): Pub. 604, 10 fev. 2021. ilus
Article in Portuguese | VETINDEX | ID: vti-30140

ABSTRACT

Background: Large skin defects are caused by tumor excision, making appropriate reconstruction and complete healingof the lesion a challenge for surgeons. There are some difficulties in reaching these goals, especially in cases of surgicalwound in the limbs, due to the scarce amount of skin and its reduced elasticity, which limit the possibility of flaps whencompared to the head, neck, and trunk. This study reports a case of wound closure on the lateral skin in the femoral regionof a dogs pelvic limb via island skin graft associated with the implantation of a non-adherent cellulose acetate mesh andintensive postoperative care.Case: An 8-year-old Rottweiler female dog was attended at Pontifical Catholic University of Paranás Veterinary Clinic(CVE) in Curitiba, Paraná, presenting a tumor located laterocaudally to the right stifle joint. After preoperative examinations the patient underwent tumor surgery; however, two more surgical procedures were required due to suture dehiscence in the region, which resulted in increased wound size. At first, the wound was treated for granulation tissue to beformed. Subsequently, the island skin grafting technique was chosen to close the wound, associated with the implantationof a non-adherent cellulose acetate mesh imbibed with petrolatum emulsion to keep the grafted fragments in place. Themesh was fixed in a simple interrupted suture pattern using 2-0 nylon thread. The lateral regions of the chest and abdomen were chosen as donor skin beds due to their large dimensions, skin elasticity, and ease in defect reconstruction. Thefragments were obtained using a 10-mm biopsy punch and scalpel, and the defects were sutured in a simple interruptedpattern using 2-0 nylon thread. The patient remained hospitalized for movement restriction and postoperative monitoringfor 72 h, and the bandage remained untouched during this time interval. Thereafter, the patient...(AU)


Subject(s)
Animals , Female , Dogs , Transplants , Skin , Dogs/surgery , Neoplasms/veterinary , Surgical Procedures, Operative/veterinary
8.
Acta sci. vet. (Online) ; 49(suppl.1): Pub. 601, Feb. 2, 2021. ilus
Article in English | VETINDEX | ID: vti-13074

ABSTRACT

Background: Hermaphroditism is a rare congenital disease that causes ambiguous sexual features. True hermaphroditeshave testicular and ovarian tissue, whereas pseudohermaphrodites have only one type of gonadal tissue and genitalia, butsecondary characteristics of the opposite sex. Pseudohermaphrodites are classified as male or female according to theirgonads. Treatment of pseudohermaphroditism consists of surgical removal of the gonads including reconstruction of abnormal genitalia, especially if the urethra is involved. Therefore, the objective of this report is to describe a case of a malepseudohermaphrodite in a dog treated with clitoridectomy with urethrostomy.Case: A 7-month-old, mixed-breed dog was referred due to the presence of a flaccid structure similar to a small penis,containing an os clitoris, bulbourethral glands, and urethra protruding from the vulva. Physical examination, completeblood count and serum biochemistry were within normal ranges. Hormonal levels of estradiol, testosterone, and progesterone were 56.39 pg/mL, 127.9 ng/mL, and 0.892 ng/mL, respectively. The abdominal ultrasound and posteriorly theexploratory celiotomy found a normal size prostate and two round organs resembling testicles connected to a uterus-liketubular structure. The patient underwent surgical abdominal exploration that confirmed the ultrasonographic findings andled to gonadohysterectomy. Also, clitoridectomy and urethrostomy were performed to excise the protruded structure andmaintain normal urethral patency. The histopathological examination of the clitoris and penis confirmed it was a malegenital organ, however, the abdominal structures were compatible with the testicles, epididymis, uterus, and even a broadligament. These organs are normally found in cases of male pseudohermaphroditism. The...(AU)


Subject(s)
Animals , Dogs , Dogs/abnormalities , Disorders of Sex Development/veterinary , Castration/veterinary , Ultrasonography/veterinary
9.
Acta sci. vet. (Impr.) ; 49(suppl.1): Pub.601-Jan 4, 2021. ilus
Article in English | VETINDEX | ID: biblio-1458464

ABSTRACT

Background: Hermaphroditism is a rare congenital disease that causes ambiguous sexual features. True hermaphroditeshave testicular and ovarian tissue, whereas pseudohermaphrodites have only one type of gonadal tissue and genitalia, butsecondary characteristics of the opposite sex. Pseudohermaphrodites are classified as male or female according to theirgonads. Treatment of pseudohermaphroditism consists of surgical removal of the gonads including reconstruction of abnormal genitalia, especially if the urethra is involved. Therefore, the objective of this report is to describe a case of a malepseudohermaphrodite in a dog treated with clitoridectomy with urethrostomy.Case: A 7-month-old, mixed-breed dog was referred due to the presence of a flaccid structure similar to a small penis,containing an os clitoris, bulbourethral glands, and urethra protruding from the vulva. Physical examination, completeblood count and serum biochemistry were within normal ranges. Hormonal levels of estradiol, testosterone, and progesterone were 56.39 pg/mL, 127.9 ng/mL, and 0.892 ng/mL, respectively. The abdominal ultrasound and posteriorly theexploratory celiotomy found a normal size prostate and two round organs resembling testicles connected to a uterus-liketubular structure. The patient underwent surgical abdominal exploration that confirmed the ultrasonographic findings andled to gonadohysterectomy. Also, clitoridectomy and urethrostomy were performed to excise the protruded structure andmaintain normal urethral patency. The histopathological examination of the clitoris and penis confirmed it was a malegenital organ, however, the abdominal structures were compatible with the testicles, epididymis, uterus, and even a broadligament. These organs are normally found in cases of male pseudohermaphroditism. The...


Subject(s)
Animals , Dogs , Dogs/abnormalities , Disorders of Sex Development/veterinary , Castration/veterinary , Ultrasonography/veterinary
10.
Acta sci. vet. (Impr.) ; 49(suppl.1): Pub.604-Jan 4, 2021. ilus
Article in Portuguese | VETINDEX | ID: biblio-1458467

ABSTRACT

Background: Large skin defects are caused by tumor excision, making appropriate reconstruction and complete healingof the lesion a challenge for surgeons. There are some difficulties in reaching these goals, especially in cases of surgicalwound in the limbs, due to the scarce amount of skin and its reduced elasticity, which limit the possibility of flaps whencompared to the head, neck, and trunk. This study reports a case of wound closure on the lateral skin in the femoral regionof a dog’s pelvic limb via island skin graft associated with the implantation of a non-adherent cellulose acetate mesh andintensive postoperative care.Case: An 8-year-old Rottweiler female dog was attended at Pontifical Catholic University of Paraná’s Veterinary Clinic(CVE) in Curitiba, Paraná, presenting a tumor located laterocaudally to the right stifle joint. After preoperative examinations the patient underwent tumor surgery; however, two more surgical procedures were required due to suture dehiscence in the region, which resulted in increased wound size. At first, the wound was treated for granulation tissue to beformed. Subsequently, the island skin grafting technique was chosen to close the wound, associated with the implantationof a non-adherent cellulose acetate mesh imbibed with petrolatum emulsion to keep the grafted fragments in place. Themesh was fixed in a simple interrupted suture pattern using 2-0 nylon thread. The lateral regions of the chest and abdomen were chosen as donor skin beds due to their large dimensions, skin elasticity, and ease in defect reconstruction. Thefragments were obtained using a 10-mm biopsy punch and scalpel, and the defects were sutured in a simple interruptedpattern using 2-0 nylon thread. The patient remained hospitalized for movement restriction and postoperative monitoringfor 72 h, and the bandage remained untouched during this time interval. Thereafter, the patient...


Subject(s)
Female , Animals , Dogs , Dogs/surgery , Skin , Transplants , Neoplasms/veterinary , Surgical Procedures, Operative/veterinary
11.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 547, Nov. 10, 2020. ilus, tab
Article in English | VETINDEX | ID: vti-765621

ABSTRACT

Background: Reconstructive surgery is an important area of veterinary surgery because it allows the reconstruction of large cutaneous defects in areas where a primary approach is not possible. Axial patterns flaps are composed by one direct cutaneous artery and vein, leading to a better blood supply with a good survival outcome. The angularis oris axial pattern buccal flap was introduced for correction of facial defects, but its versatility is not really explored in the existing literature. This article reports the use and complications of the angularis oris axial pattern buccal flap in six dogs, to treat defects in mandibular, temporal or labial regions. Cases: Five mixed breed dogs and one Labrador, with age between 4 and 9-year-old were submitted for surgery and the angularis oris axial pattern buccal flap was used to close the different defects. Causes of defect included a lesion caused by myiasis in three of the dogs, and tumoral removal in the other three, where two were mast cell tumors and one a keratinizing basal cell carcinoma. The regions affected included rostral mandible with oral mucosa, intermandibular region, temporal region and upper lip. Before flap confection the tissue was cleaned, resected and prepared properly, according to each cause of lesion. The flap was made with two parallel incisions, which center was usually the labial commissure, with the dorsal limits at the ventral aspect of the zygomatic arch, and the ventral incision on the ventral aspect of the mandibular ramus. Caudal extension was based on the length needed for surgical closure, but stained between the vertical auditory canal or up to atlas wing. Suture size and pattern depend the region and patient size. Patients were observed closely for any complication in the surgical site. From the six dogs presented here, five got some complications in the surgical site, including: lymphedema (2), suture dehiscence (4) and hematoma (1); however...(AU)


Subject(s)
Animals , Dogs , Free Tissue Flaps/transplantation , Free Tissue Flaps/veterinary , Facial Transplantation/veterinary , Skin Transplantation/veterinary , Facial Injuries/surgery , Facial Injuries/veterinary
12.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 535, Sept. 30, 2020. ilus, tab
Article in English | VETINDEX | ID: vti-765361

ABSTRACT

Background: The thrombotic aortic disease in dogs and cats is characterized by the pathological formation of blood clots that can rupture and obstruct the blood flow. Abdominal ultrasonography can identify the location and extension of thrombus in the main vasculature and using the doppler it is possible to observe the blood flow around the thrombus. Stents are expandable tube-shaped endoprosthesis characterized as a metal mesh and used to prevent or repair stenoses, allowing liquid, gas, or solids to flow. This report aims to describe the surgical and medical treatment of aortic thrombotic disease followed by coronary stents placement in a bitch. Case: An 8-year-old Shih Tzu bitch, presented for evaluation of a 1-month progressive hind limbs paresis. Nociception was present in both limbs, but the patient presented discomfort and vocalization when manipulating the pelvic limbs. A complete blood count demonstrated anemia, mild neutrophilia, and lymphopenia. Serum biochemistry found an increase in ALT, ALP, blood urea nitrogen, and CK. Abdominal ultrasonography detected mild bulging of the caudal aorta and trifurcation of the iliac arteries. Increased intraluminal echogenicity and absence of blood flow were also detected using duplex doppler. The initial medical treatment was ineffective in improving clinical signs, therefore surgical repair was performed. The aorta was isolated and clamped with Satinsky forceps and incised. The thrombus fragmented during removal. A non-compliant high-pressure balloon was used to dilated and remove small fragments of blood clots from the right and left external iliac arteries. Coronary stents of 32 mm length by 2.75 mm diameter were placed to keep both iliac arteries free. Immediately after the procedure, there was a detectable distal pulse in both hind limbs...(AU)


Subject(s)
Animals , Female , Dogs , Thrombectomy/veterinary , Thrombectomy/methods , Stents/veterinary , Venous Thrombosis/veterinary , Aorta/pathology , Aortic Diseases/veterinary
13.
Rev. bras. ciênc. vet ; 27(1): 7-13, jan./mar. 2020. il.
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1379228

ABSTRACT

O objetivo do presente estudo é relatar a construção de um retalho direto de bolsa bipediculada com fixação apendicular à região torácica para o tratamento de lesões extensas no membro torácico direito de um gato. Foi tratado no Hospital Veterinário Unicesumar Maringá - Paraná, um felino de 1 ano de idade, apresentando lesão no membro torácico, após história de briga com outro animal da mesma espécie. Ao exame físico, apresentava fístula e edema no membro torácico direito. O paciente foi anestesiado e foi realizado o desbridamento das áreas desvitalizadas. Como terapia inicial, a lesão foi tratada como ferida aberta, até a formação de tecido de granulação, para posterior correção do defeito empregando retalho bipediculado em bolsa direta, com fixação temporária do membro à parede torácica. Após duas semanas, o membro foi desimplantado e os pontos foram removidos 21 dias após a aplicação do retalho. O uso do retalho permitiu completa cicatrização da ferida, sem ocorrência de hematomas, necrose ou deiscência de sutura. Conclui-se que a utilização do retalho bipedicular é aplicável ao tratamento de feridas traumáticas em membro torácico de felinos.


The aim of the present study is to report the construction of a direct bipedicled pouch flap with appendicular fixation to the thoracic region for the treatment of extensive lesions in the right thoracic limb of a cat. He was treated on Hospital Veterinário Unicesumar Maringá - Paraná, a 1-year-old feline, presenting injury to the thoracic limb after a history of fighting with another animal of the same species. On physical examination, he presented fistula and edema in the right thoracic limb. The patient was anesthetized and debridement of the devitalized areas was performed. As an initial therapy, the lesion was treated as an open wound until granulation tissue was formed for subsequent correction of the defect using a direct pouch bipedicled flap, with temporary fixation of the limb to the chest wall. After two weeks, the limb was unimplanted and the stitches were removed 21 days after flap application. The use of the flap allowed complete wound healing without bruising, necrosis or suture dehiscence. It is concluded that the use of bipedicular flap is applicable to the treatment of traumatic wounds in feline thoracic limb.


Subject(s)
Animals , Cats , Surgical Flaps/veterinary , Wounds and Injuries/veterinary , Cats/surgery , Free Tissue Flaps/veterinary , Forearm Injuries/surgery , Surgery, Veterinary/methods , Wound Healing , Granulation Tissue/surgery
14.
Acta sci. vet. (Impr.) ; 48: Pub.1739-Jan. 30, 2020. tab, graf
Article in English | VETINDEX | ID: biblio-1458262

ABSTRACT

Background: Mast cell tumors (MCT) are among the most common malignant cutaneous neoplasm in dogs with variable biologic behavior and remain a therapeutic challenge in high-grade cases. Surgery remains the primary treatment for canine MCT; however, chemotherapy and radiation therapy are commonly used to treat aggressive cases. The combination of vinblastine (VBL) at a dose of 2 mg/m² and prednisone is the classically described protocol for MCT treatment. Studies have shown the safety of higher VBL doses for dogs with MCT, but there is a lack of information regarding dose intensity and outcome as a goal after chemotherapy. This study aimed to evaluate the impact of a higher dose of VBL on MCT treatment outcome. Materials, Methods & Results: This was an observational and comparative study conducted in two different Veterinary Teaching Hospitals. Client-owned dogs with histopathological diagnosis of grade II or III MCT were selected and underwent at least four chemotherapy sessions with VBL and prednisone. The experimental group (EG) consisted of 18 dogs that received a dose of 3 mg/m² VBL treated in one institution. The control group (CG) included 31 dogs that received a dose of 2 mg/m² VBL treated at the other institution. All dogs treated in both groups had a clinical and complete blood count (CBC) evaluation performed previous the start of chemotherapy (T0) and before each weekly treatment (T1, T2, T3, and T4). After treatment, dogs in both groups were followed-up for the recurrence rate and overall survival time after diagnosis. There was no significant difference in clinical variables between EG and CG. During treatment, dogs of EG showed a significant reduction in erythrocyte, hemoglobin, and hematocrit values between T0 and T1, T2, T3, and T4 (P < 0.001). Comparatively, the CG showed significant reduction in hemoglobin (P = 0.02) and total leucocytes (P = 0.001) values in the same period. Despite these findings, these hematological...


Subject(s)
Animals , Dogs , Mastocytoma, Skin/drug therapy , Mastocytoma, Skin/veterinary , Prednisone/administration & dosage , Vinblastine/administration & dosage , Vinblastine/therapeutic use , Blood Cell Count/veterinary
15.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.535-4 jan. 2020. ilus, tab
Article in English | VETINDEX | ID: biblio-1458362

ABSTRACT

Background: The thrombotic aortic disease in dogs and cats is characterized by the pathological formation of blood clots that can rupture and obstruct the blood flow. Abdominal ultrasonography can identify the location and extension of thrombus in the main vasculature and using the doppler it is possible to observe the blood flow around the thrombus. Stents are expandable tube-shaped endoprosthesis characterized as a metal mesh and used to prevent or repair stenoses, allowing liquid, gas, or solids to flow. This report aims to describe the surgical and medical treatment of aortic thrombotic disease followed by coronary stents placement in a bitch. Case: An 8-year-old Shih Tzu bitch, presented for evaluation of a 1-month progressive hind limbs paresis. Nociception was present in both limbs, but the patient presented discomfort and vocalization when manipulating the pelvic limbs. A complete blood count demonstrated anemia, mild neutrophilia, and lymphopenia. Serum biochemistry found an increase in ALT, ALP, blood urea nitrogen, and CK. Abdominal ultrasonography detected mild bulging of the caudal aorta and trifurcation of the iliac arteries. Increased intraluminal echogenicity and absence of blood flow were also detected using duplex doppler. The initial medical treatment was ineffective in improving clinical signs, therefore surgical repair was performed. The aorta was isolated and clamped with Satinsky forceps and incised. The thrombus fragmented during removal. A non-compliant high-pressure balloon was used to dilated and remove small fragments of blood clots from the right and left external iliac arteries. Coronary stents of 32 mm length by 2.75 mm diameter were placed to keep both iliac arteries free. Immediately after the procedure, there was a detectable distal pulse in both hind limbs...


Subject(s)
Female , Animals , Dogs , Aorta/pathology , Stents/veterinary , Thrombectomy/methods , Thrombectomy/veterinary , Venous Thrombosis/veterinary , Aortic Diseases/veterinary
16.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.547-4 jan. 2020. ilus, tab
Article in English | VETINDEX | ID: biblio-1458374

ABSTRACT

Background: Reconstructive surgery is an important area of veterinary surgery because it allows the reconstruction of large cutaneous defects in areas where a primary approach is not possible. Axial patterns flaps are composed by one direct cutaneous artery and vein, leading to a better blood supply with a good survival outcome. The angularis oris axial pattern buccal flap was introduced for correction of facial defects, but its versatility is not really explored in the existing literature. This article reports the use and complications of the angularis oris axial pattern buccal flap in six dogs, to treat defects in mandibular, temporal or labial regions. Cases: Five mixed breed dogs and one Labrador, with age between 4 and 9-year-old were submitted for surgery and the angularis oris axial pattern buccal flap was used to close the different defects. Causes of defect included a lesion caused by myiasis in three of the dogs, and tumoral removal in the other three, where two were mast cell tumors and one a keratinizing basal cell carcinoma. The regions affected included rostral mandible with oral mucosa, intermandibular region, temporal region and upper lip. Before flap confection the tissue was cleaned, resected and prepared properly, according to each cause of lesion. The flap was made with two parallel incisions, which center was usually the labial commissure, with the dorsal limits at the ventral aspect of the zygomatic arch, and the ventral incision on the ventral aspect of the mandibular ramus. Caudal extension was based on the length needed for surgical closure, but stained between the vertical auditory canal or up to atlas wing. Suture size and pattern depend the region and patient size. Patients were observed closely for any complication in the surgical site. From the six dogs presented here, five got some complications in the surgical site, including: lymphedema (2), suture dehiscence (4) and hematoma (1); however...


Subject(s)
Animals , Dogs , Free Tissue Flaps/transplantation , Free Tissue Flaps/veterinary , Facial Transplantation/veterinary , Skin Transplantation/veterinary , Facial Injuries/surgery , Facial Injuries/veterinary
17.
Nosso Clín. ; 22(132): 22-25, nov.-dez. 2019. ilus
Article in Portuguese | VETINDEX | ID: vti-26975

ABSTRACT

O tricolemoma é uma neoplasia benigna, rara em cães, que se originam da bainha externa da raiz do folículo piloso. O presente trabalho relata um caso de tricolemoma em cadela da raça Serra da Estrela, fêmea de 9 anos que veio para atendimento no Hospital Veterinário Central - Portugal. O tumor apresentava 9 cm de diâmetro, não aderido, de consistência firme e ulcerado. Foi associada, após ressecção do nódulo, reconstrução com retalho de padrão subdérmico em H-plastia. Após 10 dias houve deiscência na porção medial do retalho, necessitando de nova intervenção cirúrgica. O laudo histológico revelou tricolemoma Istmico, neoplasia que apresenta o prognóstico bom, pois após a excisão cirúrgica raramente apresentam recidiva tendo efeito curativo.(AU)


The tricholemmoma is a benign neoplasm, rare in dogs, which originate from the outer sheath of the hair follicle root. This paper reports a case of tricholemmoma in the Serra da Estrela dog race, female and 9 years old, who came to be attended in the Central Veterinary Hospital - PT. The nodule had 9 cm of diameter, not joined, firm consistency and ulcerated. Was associated reconstruction with subdermal flap inH-plastia after ressection the nodule. It performed excision of the nodule and reconstructive surgery in Hplasty. After 10 days there was dehiscence in the medial part of the flap, requiring further surgical intervention. The histological report revealed tricholemmoma isthmic, neoplasm that presents a good prognosis because after surgical excision rarely suffer relapses with curative effect.(AU)


El tricolemoma es una neoplasia benigna, rara en perros, que se originan de lavaina externade la raiz dei folículo piloso. Se presenta el caso de tricolemoma en la raza de perro Sierra de la Estrella, hembra de 9 anos que vinieron a atención al Hospital Veterinario Central - Portugal. EI tumor presentaba 9 cm de diámetro, no adherido, de consistencia firme y ulcerada. Se asoció, después de Ia resección del nódulo, reconstrucción con el colgajo de patrón subdérmico en H-plastia. Después de 10 dias hubo dehiscencia en la porción medial del colgajo, necesitando de nueva intervención quirúrgica. El laudo histológico reveló tricolemoma Istmico, neoplasia que presenta el pronóstico bueno, pues después de la excisión quirúrgica raramente presentan recidiva teniendo efecto curativo.(AU)


Subject(s)
Animals , Female , Dogs , Neoplasms/surgery , Neoplasms/rehabilitation , Hair Follicle , Plastic Surgery Procedures , Surgical Wound Dehiscence
18.
Nosso clínico ; 22(132): 22-25, nov.-dez. 2019. ilus
Article in Portuguese | VETINDEX | ID: biblio-1486150

ABSTRACT

O tricolemoma é uma neoplasia benigna, rara em cães, que se originam da bainha externa da raiz do folículo piloso. O presente trabalho relata um caso de tricolemoma em cadela da raça Serra da Estrela, fêmea de 9 anos que veio para atendimento no Hospital Veterinário Central - Portugal. O tumor apresentava 9 cm de diâmetro, não aderido, de consistência firme e ulcerado. Foi associada, após ressecção do nódulo, reconstrução com retalho de padrão subdérmico em H-plastia. Após 10 dias houve deiscência na porção medial do retalho, necessitando de nova intervenção cirúrgica. O laudo histológico revelou tricolemoma Istmico, neoplasia que apresenta o prognóstico bom, pois após a excisão cirúrgica raramente apresentam recidiva tendo efeito curativo.


The tricholemmoma is a benign neoplasm, rare in dogs, which originate from the outer sheath of the hair follicle root. This paper reports a case of tricholemmoma in the Serra da Estrela dog race, female and 9 years old, who came to be attended in the Central Veterinary Hospital - PT. The nodule had 9 cm of diameter, not joined, firm consistency and ulcerated. Was associated reconstruction with subdermal flap inH-plastia after ressection the nodule. It performed excision of the nodule and reconstructive surgery in Hplasty. After 10 days there was dehiscence in the medial part of the flap, requiring further surgical intervention. The histological report revealed tricholemmoma isthmic, neoplasm that presents a good prognosis because after surgical excision rarely suffer relapses with curative effect.


El tricolemoma es una neoplasia benigna, rara en perros, que se originan de lavaina externade la raiz dei folículo piloso. Se presenta el caso de tricolemoma en la raza de perro Sierra de la Estrella, hembra de 9 anos que vinieron a atención al Hospital Veterinario Central - Portugal. EI tumor presentaba 9 cm de diámetro, no adherido, de consistencia firme y ulcerada. Se asoció, después de Ia resección del nódulo, reconstrucción con el colgajo de patrón subdérmico en H-plastia. Después de 10 dias hubo dehiscencia en la porción medial del colgajo, necesitando de nueva intervención quirúrgica. El laudo histológico reveló tricolemoma Istmico, neoplasia que presenta el pronóstico bueno, pues después de la excisión quirúrgica raramente presentan recidiva teniendo efecto curativo.


Subject(s)
Female , Animals , Dogs , Surgical Wound Dehiscence , Hair Follicle , Neoplasms/surgery , Neoplasms/rehabilitation , Plastic Surgery Procedures
19.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 426, Oct. 5, 2019. ilus
Article in English | VETINDEX | ID: vti-25715

ABSTRACT

Background: The ectopic ureter (EU) is considered a congenital anomaly in which the ureteral aperture opens in a positionother than the bladder neck. The diagnosis involves the use of different methods or combination of image exams, including excretory urography, pneumocystography, ultrasonography, cystoscopy and computed tomography. The technics forsurgical repair should be considered evaluating the number and functionality of the EU, the location of the ureteral opening, functional condition of ipsilateral kidney and the presence of other abnormalities. The case reports aims to show thesurgical repair of an intramural EU in an English Bulldog bitch by cystoscopy-guided monopolar cautery.Case: A 1-year-old English Bulldog bitch received medical care due to a history of urinary incontinence since a few monthsof life. The animal had laboratory abnormalities compatible with lower urinary tract infection, followed by a profoundgrowth of Klebsiella sp in urine culture, and received antibiotic treatment for 21 days based on antibiogram results. Dueto a suspect EU, a urinary tract tomography was performed and indicated a congenital kidney malformation (renal dysplasia), enlargement and distal insertion of the left ureter (in comparison with the contralateral one), rising suspiciously ofits intramural progression. We choose to proceed to cystoscopy examination, in which both right and left ureteral ostiumcould be seen in the urethral region. A guide of a pigtail catheter was inserted through both ureteral ostia in order to orientthe ureteral incision. The monopolar cautery was inserted in cystoscopy working channel to section the mucosa of EUchannel on urethra region, separating the lumen of EU from the urethra and extending the incision cranially inside theurinary bladder lumen. After a complete section of the ectopic tissue, a pigtail urinary catheter was correctly placed inboth ureters...(AU)


Subject(s)
Animals , Female , Dogs , Cautery/methods , Cautery/veterinary , Cystoscopy/veterinary , Ureter/surgery
20.
Open Vet J ; 9(2): 106-108, 2019 07.
Article in English | MEDLINE | ID: mdl-31360647

ABSTRACT

An 8-yr old, neutered female Doberman Pinscher was presented for dermatological evaluation due to numerous pruritic, non-pigmented nodules that created a plaque in the lumbo-sacral region. This report is the first published photographic record of an acrochordonous plaque in a dolichocephalic dog and is the first reported case in Brazil.


Subject(s)
Dog Diseases/diagnosis , Lumbosacral Region/pathology , Skin Neoplasms/veterinary , Animals , Brazil , Diagnosis, Differential , Dog Diseases/pathology , Dogs , Female , Skin Neoplasms/diagnosis
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