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Eur J Orthop Surg Traumatol ; 33(6): 2489-2496, 2023 Aug.
Article in English | MEDLINE | ID: mdl-36547706

ABSTRACT

PURPOSE: Bone transport is one of the most frequently used techniques for critical-sized bone defects due to trauma or infection. To fill the defect area and avoid the collapse of soft tissues during transport, some authors have described the use of polymethylmethacrylate or absorbable antibiotic carriers in the form of cylindrical blocks. METHODS: In this article, we present our experience in the treatment of post-traumatic osteomyelitis of the lower and upper limbs, using a bone transport technique with antibiotic-loaded calcium sulfate in the form of beads. Results With the progressive absorption of calcium sulfate, we observed the formation of a bone-like tissue envelope at the periphery of the defect area. Histological analysis and direct visualization during open revision surgery of the docking site in all patients confirmed the presence of newly formed bone tissue with a high presence of osteoblasts and few osteoclasts; no areas of necrosis or signs of infection were observed. This bone envelope maintained the mechanical protective function of the transport path and docking site, and also provided a biological stimulus to avoid the development of necrotic areas and optimize the consolidation phase. Conclusion Bone transport with calcium sulfate beads improves biological and mechanical support and reduces the number of surgeries required.


Subject(s)
Anti-Bacterial Agents , Osteomyelitis , Humans , Anti-Bacterial Agents/therapeutic use , Calcium Sulfate , Osteogenesis , Bone and Bones , Osteomyelitis/drug therapy , Osteomyelitis/surgery , Treatment Outcome
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