ABSTRACT
BACKGROUND: Cancer is the most serious world's health problems on the global level and various strategies have been developed for cancer therapy. Pillar[5]arene-based supramolecular therapeutic nano-platform (SP/GOx NPs) was constructed successfully via orthogonal dynamic covalent bonds and intermolecular H-bonds with the assistance of glucose oxidase (GOx) and exhibited efficient targeted/synergistic chemo-chemodynamic cancer therapy. METHODS: The morphology of SP/GOx NPs was characterized by DLS, TEM, SEM and EDS mapping. The cancer therapy efficinecy was investigated both in vivo and in vitro. RESULTS: SP/GOx NPs can load drug molecules (Dox) and modify target molecule (FA-Py) on its surface conveniently. When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2. Subsequently, the generated H2O2 in cancer cells catalyzed by ferrocene unit to form â¢OH, which can kill cancer cells. Furthermore, the loaded Dox molecules released under acid microenvironment, which can further achieve chemo-therapy. CONCLUSION: All the experiments showed that the excellent antitumor performance of FA-Py/SP/GOx/Dox NPs, which provided an new method for pillar[5]arene-based supramolecular polymer for biomedical applications.
Subject(s)
Antineoplastic Agents , Calixarenes , Glucose Oxidase , Nanoparticles , Quaternary Ammonium Compounds , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/metabolism , Antineoplastic Agents/pharmacology , Calixarenes/chemistry , Calixarenes/metabolism , Cell Survival/drug effects , Doxorubicin/chemistry , Doxorubicin/metabolism , Doxorubicin/pharmacology , Drug Synergism , Glucose Oxidase/chemistry , Glucose Oxidase/metabolism , Hydrogen Peroxide , Mice , Nanoparticles/chemistry , Nanoparticles/metabolism , Polymers/chemistry , Polymers/metabolism , Quaternary Ammonium Compounds/chemistry , Quaternary Ammonium Compounds/metabolismABSTRACT
The development of the supramolecular coordination complex with different shapes and dimensionalities lays the basis for its application in different areas. In this study, a porphyrin-based 3D organo-Pt(II) metallatriangle (MTA) was fabricated through the reported method termed as "coordination driven self-assembly". 31P NMR, 1H NMR, HR-MS, and theoretical calculation were employed to characterize the resultant MTA fully. Furthermore, the fabricated nanocomposite through coassembly of MTA and an amphiphilic polypeptide (PEG-PPT) could generate singlet oxygen (1O2) under the NIR irradiation and release a Pt drug under a low-pH microenvironment. 1O2 and the Pt drug can both damage the cancer cells, which improves the efficiency of cancer therapies. The fabrication of a Pt-porphyrin metallatriangle expands the topological structures, and the Pt-porphyrin metallatriangle can be applied to the combined cancer therapies. Moreover, various stimuli-responsive groups can be modified to the triangle, so a new method is created to develop high-performance biosupramolecular materials.
Subject(s)
Antineoplastic Agents/pharmacology , Organoplatinum Compounds/pharmacology , Peptides/pharmacology , Photochemotherapy , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Cell Proliferation/drug effects , Cell Survival/drug effects , Drug Screening Assays, Antitumor , HeLa Cells , Humans , Molecular Structure , Organoplatinum Compounds/chemical synthesis , Organoplatinum Compounds/chemistry , Particle Size , Peptides/chemistryABSTRACT
Pillar[n]arene-based supramolecular polymers have attracted great interest because of their tunable morphologies and external stimuli responsiveness. However, most of the investigations of supramolecular polymers previously reported were focused on their formation and transformation, and investigations on their applications are rare. Herein, we designed and prepared hybrid polymeric materials by incorporating Pd nanoparticles into a supramolecular polymer, constructed from a pillar[5]arene dimer and a three-arm guest. The obtained hybrid polymer was fully characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, scanning electron microscopy-energy-dispersive X-ray mapping, and X-ray diffraction technologies. Importantly, the hybrid supramolecular polymeric materials exhibited desirable catalytic activity for reductions of toxic nitroaromatics and C-C bond-forming Suzuki-Miyaura reaction in aqueous solution.
ABSTRACT
The first pillar[6]arene-based supramolecular polymeric material constructed from electrostatic interactions was designed and prepared successfully. Importantly, it can adsorb and remove organic dye from water efficiently.
ABSTRACT
An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions.
Subject(s)
Copper/chemistry , Mitochondria/metabolism , Nanocapsules/chemistry , Nitric Oxide/chemistry , Sulfides/chemistry , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Drug Liberation , Gene Expression Regulation/drug effects , HSP90 Heat-Shock Proteins/genetics , HSP90 Heat-Shock Proteins/metabolism , Humans , Hyperthermia, Induced , Infrared Rays , Nitric Oxide/pharmacology , Organophosphorus Compounds/chemistry , Photothermal Therapy , Polyethyleneimine/chemistry , Theranostic NanomedicineABSTRACT
With the rapid progress of nanotechnology, near-infrared (NIR), light-assisted phototherapy as a minimally invasive local cancer therapy, especially photothermal therapy (PTT), has captured broad research attention in recent years. However, combined target molecules with a PTT system through reversible supramolecular interactions has been reported rarely. In this work, we constructed a supramolecular nanosystem combining ATP capture and target PTT based on cationic pillar[5]arene (CWP5)-functionalized Cu2-xSe nanoparticles (Cu2-xSe@CWP5 NPs). Cu2-xSe@CWP5 NPs, with an average diameter of approximately 100 nm and strong absorption in the near-infrared-II window, were prepared in water through a facile one-step in situ synthesis method, then (4-carboxybutyl)triphenylphosphonium bromide (TPP), a mitochondria-targeted molecule, was modified on the surface of the particles through the host-guest recognition. Upon irradiation with a 1064 nm laser, the obtained Cu2-xSe@CWP5/TPP NPs showed remarkably photothermal ablation capability to HeLa cells. Importantly, our Cu2-xSe@CWP5/TPP NPs exhibited excellent therapeutic effect due to the combination of inhibited hydrolysis of ATP and targeted photothermal therapy upon in vitro and in vivo studies. Significantly, through host-guest interactions, we can modify different types of target molecules within this PTT system at will.
ABSTRACT
A new amphiphilic organoplatinum(ii) metallaclip was designed and fabricated successfully through coordination driven self-assembly. It can further self-assemble into multi-dimensional well-defined micro-structures with different CH3OH/H2O ratios, and show enhanced fluorescence emission in water.
ABSTRACT
Water-soluble -CH2- bridged acyclic naphthalene oligomers (WN2 and WN3) were designed and prepared successfully. Interestingly, WN3 can be used in reversible dispersion of carbon nanotubes in water by changing the pH efficiently.
ABSTRACT
An amphiphilic metallacage with tetragonal prismatic frameworks as a hydrophobic core and pendent tri(ethylene glycol) chains as hydrophilic tails was prepared successfully and showed controllable self-assembly behaviour in water.
ABSTRACT
A new amphiphilic pillar[5]arene with excellent surface activity was designed and synthesized successfully for the first time. Interestingly, this pillar[5]arene shows controllable self-assembly behaviour in water and can be applied in white-light-emitting systems.
