ABSTRACT
AIM: To explore the value of radiomics for predicting the expression of programmed death ligand 1 (PD-L1) in non-small-cell lung cancer (NSCLC) based on multiparameter spectral computed tomography (CT) images. MATERIALS AND METHODS: A total of 220 patients with NSCLC were enrolled retrospectively and divided into the training (n=176) and testing (n=44) cohorts. The radiomics features were extracted from the conventional CT images, mono-energy 40 keV images, iodine density (ID) maps, Z-effective maps, and electron density maps. The logistic regression (LR) and support vector machine (SVM) algorithms were employed to build models based on radiomics signatures. The prediction abilities were qualified by the area under the curve (AUC) obtained from the receiver operating characteristic (ROC) curve. Internal validation was performed on the independent testing dataset. RESULTS: The combined model for PD-L1 ≥1%, which consisted of the radiomics score (rad-score; p<0.0001), white blood cell (WBC; p=0.027) counts, and air bronchogram (p=0.003), reached the highest performance with the AUCs of 0.873 and 0.917 in the training and testing dataset, respectively, which was better than the radiomics model with the AUCs of 0.842 and 0.886. The combined model for PD-L1 ≥50%, which consisted of rad-score (p<0.0001) and WBC counts (p=0.027), achieved the highest performance in the training and testing dataset with AUCs of 0.932 and 0.903, respectively, which was better than the radiomics model with AUCs of 0.920 and 0.892, respectively. CONCLUSION: The radiomics model based on the multiparameter images of spectral CT can predict the expression level of PD-L1 in NSCLC. The combined model can obtain higher prediction efficiency and serves as a promising method for immunotherapy selection.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Humans , B7-H1 Antigen , Carcinoma, Non-Small-Cell Lung/diagnostic imaging , Radiomics , Retrospective Studies , Lung Neoplasms/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Using optical visual aids, visual rehabilitation was performed in 14 cases (25 eyes) for low-vision patients with aging macular degeneration (AMD). With distance aids, visual acuity improvements were recorded for 24 eyes (95 percent) out of 25 eyes. Twelve eyes (48 percent) achieved vision equal to or better than 0.4. Utilizing near visual aids, the near visual acuity for all eyes (100 percent) were improved. Thirteen eyes (52 percent) received near vision equal to or better than 0.5. Ten patients were able to read No. 5 equal to or better than 0.5. Ten patients were able to read No. 5 Chinese print (corresponding visual angle is 0.67 at 30 cm of reading distance). The reading success rate was 71.4 percent. The results suggest that the application of visual aids is an effective method to improve the distance and near visual acuity of low vision patients with AMD.
Subject(s)
Lenses , Macular Degeneration/complications , Vision, Low/rehabilitation , Aged , Female , Humans , Male , Middle Aged , Sensory Aids , Vision, Low/etiology , Visual AcuityABSTRACT
Using optical visual aids, visual rehabilitation was performed in 14 low vision patients (25 eyes) with age-related macular degeneration. With distance aids, visual acuity improvement appeared in 24 eyes (95%) out of the 25 eyes. Twelve eyes (48%) obtained a visual acuity equal to or better than 0.4. With near visual aids, near acuity of all eyes (100%) was improved. Thirteen eyes (52%) got the near vision equal to or better than 0.5. Ten patients could read No. 5 Chinese Reading Card. The reading success rate was 71.4%. The results suggest that application of visual aids is an effective method to improve the distant and near visual acuity of low vision patients with AMD.
Subject(s)
Audiovisual Aids , Macular Degeneration/rehabilitation , Vision, Low/rehabilitation , Aged , Female , Humans , Macular Degeneration/complications , Male , Middle Aged , Vision, Low/etiology , Visual AcuityABSTRACT
Using optical visual aids, visual rehabilitation were performed in 14 cases (25 eye) of low vision patients with aging macular unity of all eyes (100%) was improved. Thirteen eyes (52%) got the near vision equal to or better than 0.5. Ten patients could read No. 5 Chinese Reading Card. The reading success rate was 71.4%. The results suggest that application of visual aids is an effective method to improve the distance and near visual acuity of low vision patients with AMD.
