ABSTRACT
BACKGROUND: Our study explored the relationship between the molecular changes in cancer and the maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) with [18F] fluorodeoxyglucose (18F-FDG). RESULTS: A higher SUVmax correlated with TP53 alterations, but not with histologic diagnosis or other gene/pathway mutations or copy number alterations. In data from breast, lung and colon cancer, patients with the highest SUVmax show more genomic anomalies compared to those with the lowest SUVmax (P < 0.005). CONCLUSIONS: A higher SUVmax on 18F-FDG PET/CT is associated with TP53 tumor suppressor gene anomalies and the presence of more genomic anomalies. Since TP53 alterations and high SUVmax both correlate with a poor prognosis, the underlying mechanism/implications of this association merit further study. METHODS: Overall, 176 patients with diverse cancers had a tumor biopsy within 6 months after a PET/CT image for SUVmax measurement. The biopsy was interrogated by next generation sequencing (182 to 315 genes). TP53, EGFR, ALK, MYC, MET and FGF/FGFR genes and DNA repair, PI3K/Akt/mTOR (PAM), MEK, CYCLIN, and WNT pathway genes were analyzed.
ABSTRACT
UNLABELLED: Given the frequency and severity of overuse injuries in pediatric athletes and the potential for long-term deleterious effects, it is important for radiologists to have a comprehensive understanding of these injuries and their imaging spectrum. This article addresses chronic overuse injuries involving the upper extremity in the pediatric athlete. Chronic upper extremity overuse injuries in competitive pediatric athletes yield imaging findings that can be subtle, obvious and characteristic, or atypical. Prompt application of the appropriate imaging modalities and their accurate interpretation expedites management, returning the pediatric athlete to the playing field while minimizing long-term adverse outcomes. SUMMARY STATEMENT: Proper modality selection and interpretation in the imaging evaluation of upper extremity overuse injuries in pediatric athletes include an understanding of skeletal development, mechanism of injury, and clinical presentation to provide accurate diagnoses and mitigate long-term adverse sequelae. LEARNING OBJECTIVES: After reading this article and taking the test, the reader will be able to: ⢠Describe the clinical presentation and imaging characteristics of a variety of pediatric overuse injuries in the upper extremity including little league shoulder, rotator cuff tendinosis, gymnast wrist, climber's finger, and myriad pathologies about the elbow. ⢠Explain how the physis plays a crucial role in pediatric overuse injury and how to evaluate physeal injury in a multimodal approach. ⢠Understand the clinical management for certain pediatric overuse injuries, especially those that have potential for long-term and/or permanent disability.
Subject(s)
Athletes , Athletic Injuries/diagnosis , Cumulative Trauma Disorders/diagnosis , Diagnostic Imaging , Upper Extremity/pathology , Child , HumansABSTRACT
Objective. To present a unique case report of a Lisfranc fracture in a patient with a bipartite medial cuneiform and to evaluate the prevalence of the bipartite medial cuneiform in a retrospective review of 1000 magnetic resonance (MR) imaging studies of the foot. Materials and Methods. Case report followed by a retrospective review of 1000 MR imaging studies of the foot for the presence or absence of a bipartite medial cuneiform. Results. The incidence of the bipartite medial cuneiform is 0.1%. Conclusion. A bipartite medial cuneiform is a rare finding but one with both clinical and surgical implications.
ABSTRACT
Paralleling the growing popularity of organized sports among pediatric athletes, the stress and intensity of training regimens has escalated the frequency and severity of pediatric overuse injuries. It is essential that radiologists have a thorough knowledge of the pathogenesis of these injuries and of their characteristic patterns with different imaging techniques in order to appropriately diagnose overuse injuries in the pediatric skeleton. Knowledge of the classification, mechanism, clinical and imaging manifestations of acute and chronic overuse injuries of the lower extremities common among pediatric athletes can assist in imaging-based diagnosis and characterization of injury.
