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Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine; Lakaye, Bernard; Risold, Pierre-Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis; Guyon, Alice.

Nat Neurosci ; 16(7): 845-7, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23708141

ABSTRACT

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Subject(s)

Cerebral Ventricles/anatomy & histology , Cilia/physiology , Ependyma/anatomy & histology , Hypothalamic Hormones/pharmacology , Melanins/pharmacology , Pituitary Hormones/pharmacology , Adenosine Triphosphate/pharmacology , Animals , Brain/cytology , Calcium/metabolism , Cerebral Ventricles/drug effects , Cerebrospinal Fluid/drug effects , Cerebrospinal Fluid/metabolism , Cilia/drug effects , Electric Stimulation , Female , Hormone Antagonists/pharmacology , Hypothalamic Hormones/deficiency , In Vitro Techniques , Male , Melanins/deficiency , Mice , Mice, Inbred C57BL , Mice, Transgenic , Nerve Tissue Proteins/metabolism , Neurons/drug effects , Neurons/metabolism , Pituitary Hormones/deficiency , Receptors, Somatostatin/deficiency , Receptors, Somatostatin/genetics , Serotonin/pharmacology

ABSTRACT

Subject(s)

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