Subject(s)
2S Albumins, Plant/immunology , Antigens, Plant/immunology , Arachis/immunology , Basophils/immunology , Glycoproteins/immunology , Peanut Hypersensitivity/diagnosis , Plant Extracts/immunology , Basophil Degranulation Test , Cells, Cultured , Follow-Up Studies , Humans , Immune Tolerance , Immunization , Phosphoric Diester Hydrolases/metabolism , Predictive Value of Tests , Prognosis , Pyrophosphatases/metabolism , Tetraspanin 30/metabolismABSTRACT
We report a 69-year-old adult case with a monoclonal gammopathy incidentally discovered, associated with a moderate thrombocytopenia of 90 G/L. Study of blood smear revealed the presence of tumor cells presenting Auer rod-like inclusions, although there were not blast cells. Blood cytology as well as immunophenotyping allowed us to make the diagnosis of malignant hemopathy.
Subject(s)
Carcinoma, Hepatocellular/diagnosis , Inclusion Bodies/pathology , Leukocytes/pathology , Liver Neoplasms/diagnosis , Paraproteinemias/pathology , Aged , Carcinoma, Hepatocellular/complications , Carcinoma, Hepatocellular/pathology , Diagnosis, Differential , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/pathology , Liver Neoplasms/complications , Liver Neoplasms/pathology , Male , Paraproteinemias/complications , Paraproteinemias/diagnosis , Thrombocytopenia/complications , Thrombocytopenia/pathologyABSTRACT
BACKGROUND: The case of a central nervous system human herpes virus type 6 (HHV-6) and Toxoplasma gondii co-infection after an umbilical cord blood transplantation in a chronic myelomonocytic leukaemia patient is reported. CASE REPORT: A 65-year-old Caucasian man underwent an umbilical cord blood transplantation within the context of chronic myelomonocytic leukaemia. On day 37 post-graft, he presented with a severe headache; PCRs of cerebrospinal fluid and blood were positive for T. gondii and HHV-6. The patient was treated with pyrimethamine and sulfadiazine associated with ganciclovir. CONCLUSION: HHV-6 reactivation can trigger a reactivation of T. gondii. This case suggests that patients who are seropositive for T. gondii and who present with HHV-6 reactivation should be monitored closely for toxoplasmosis.
