Longitudinal effects of obesity on pulmonary function in obese children and adolescents.

BACKGROUND: To investigate the longitudinal effects of obesity on change in lung function after 1 year of follow-up in obese children and adolescents. METHODS: Obese children/adolescents aged 8-15 years with pulmonary function test (PFT) results and recorded anthropometric obesity indices from 1 year earlier for comparison were recruited. Multiple linear regression of change in each lung function parameter was applied to determine the effect of sex, change in body mass index (ΔBMI), change in chest circumference (ΔCC), change in waist circumference (ΔWC), and change in waist circumference-to-height ratio (ΔWC/Ht). RESULTS: Sixty-six children/adolescents (mean age: 12.5 ± 2.6 years) were recruited. Multiple linear regression analysis showed that ΔWC negatively affects the ratio of the forced expiratory volume in the first 1 s to the forced vital capacity of the lungs Δ(FEV1/FVC) (b = -0.3, p = 0.002), forced expiratory flow rate within 25-75% of vital capacity (ΔFEF25-75%) (b = -0.92, p = 0.006), and Δ(FEF25-75%/FVC) (b = -0.99, p = 0.003). When replacing ΔWC with Δ(WC/Ht) as the independent variable, Δ(WC/Ht) also negatively affects Δ(FEV1/FVC) (b = -33.71, p = 0.02), ΔFEF25-75% (b = -102.9, p = 0.03) and Δ(FEF25-75%/FVC) (b = -102.7, p = 0.03). CONCLUSION: After 1 year of follow-up, change in abdominal adiposity determined by WC and WC/Ht exerted significant negative effect on lung function change specific to FEV1/FVC, FEF25-75% /FVC, and FEF25-75%. IMPACT: Longitudinal effects of change in obesity on lung function in obese children and adolescents are evidenced. Change in waist circumference or waist-to-height ratio, which indicates abdominal adiposity, was inversely correlated with a change in FEV1/FVC, FEF25-75% /FVC, and FEF25-75% in children and adolescents with obesity after 1 year of follow-up. Our results suggest using waist circumference and/or waist-to-height ratio in addition to BW and/or BMI for monitoring obesity. Fat loss programs, especially those focused on reducing abdominal adiposity should be encouraged to prevent late lung function impairment.

Incidence and risk factors for long COVID in children with COVID-19 pneumonia.

BACKGROUND AND OBJECTIVE: There are only a few reports of long COVID including pulmonary function in children after COVID-19 pneumonia. We determined the incidence of long COVID and abnormal pulmonary function in those children and identify risk factors. METHODS: This cohort study enrolled children admitted with COVID-19 pneumonia during 2021-2022. We gathered clinical characteristics during admission and at follow-up 3 months after. RESULTS: We determined the incidence of long COVID at 39.7% (95% confidence interval [CI]: 30.7%-49.1%). All severe pneumonia cases consistently reported persistent symptoms. Exercise intolerance, cough, and fatigue were the three most common persistent symptoms in 26 (22.4%), 21 (18.1%), and 18 (15.5%) of the patients, respectively. At the follow-up, 21 cases (18.1%) demonstrated persistent abnormal chest radiographs. Three cases (6.9%) demonstrated restrictive ventilatory defects. Among those, one case (2.3%) demonstrated concomitant diffusion defect. Three cases (6.0%) demonstrated exercise-induced hypoxemia after the 6-minute walk test. Comparing spirometry variables between children with long COVID and without revealed significant difference of FEF25-75 (z score) between two groups. Age [adjusted OR (95% CI): 1.13 (1.05-1.22), p value 0.002], allergic diseases [adjusted OR (95% CI): 4.05 (1.36-12.06), p value 0.012], and living in polluted areas [adjusted OR (95% CI): 2.73 (1.18-6.33), p value 0.019] were significantly associated with long COVID. CONCLUSION: A significant percentage of children developed long COVID after COVID-19 pneumonia. We should give additional attention to those who have exercise intolerance, chronic cough, or fatigue, especially older children, severe cases, children with allergic diseases, and those living in polluted areas.

Impact of respiratory care training and family support using telemedicine on tracheostomized children admitted with respiratory infection after discharge.

OBJECTIVE: Children with tracheostomies usually require a long hospital stay, high healthcare costs and caregiver burden. With the help of telemedicine, this study attempted to determine how home respiratory care training and family support affected admission days, admission costs, ICU admission rates, and caregivers' confidence. METHODS: We enrolled children with tracheostomies who were admitted between 2020 and 2022 with respiratory infections. Before discharge, we evaluated the knowledge and skills of the caregivers and gave them practice in home respiratory care while providing them with structured feedback using a checklist, a peer-to-peer mentor assignment, a virtual home visit, teleeducation, and teleconsultation via a mobile application. We compared the admission days, admission costs, and ICU admission rates one year following the program with the historical control one year earlier. RESULTS: Forty-eight children with tracheostomies were enrolled. Thirteen percent of those had a 1-year readmission. The median [IQR] number of admission days decreased from 55 [15-140] to 6 [4-17] days (p value < 0.001). The median [IQR] admission costs decreased from 300,759 [97,032 - 1,132,323] to 33,367 [17,898-164,951] baht (p value < 0.001). The ICU admission rates decreased from 43.8% to 2.1% (p value < 0.001). Immediately after the program, caregivers' confidence increased from 47.9% to 85.5% (p value < 0.001). CONCLUSIONS: This respiratory care training and telehealth program decreased admission days, admission costs, and ICU admission rates for children with tracheostomies admitted with respiratory infections. The confidence of caregivers was also increased immediately after the program.