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CONTEXT: Ammonium perchlorate (NH4ClO4, abbreviated as AP) has the advantages of high oxygen content, high density, and good compatibility, and has significant application prospects in the field of energetic materials. The crystal morphology has a great influence on the properties and sensibility of energetic materials, and a single experimental means is difficult in exploring the crystals; therefore, the crystal morphology of AP is investigated using molecular dynamics simulation complemented with experiments, to theoretically analyze the differences in AP crystal habit and the interactions between solvent molecules and the main growing crystal surfaces of AP. The results show that AP crystal is mainly composed of five independent crystal surfaces (0 0 1), (0 1 0), (1 0 0), (1 0 1), and (1 0 -1) in vacuum using the BFDH laws, with (0 0 1) surface being the main growth crystal surface. In contrast, in H2O solvent, the (1 0 1) and (1 0 -1) surfaces disappear, and the AP mainly consists of (0 0 1), (0 1 0), and (1 0 0) surfaces with a rectangular shape. The crystal morphology obtained from theoretical prediction is in good agreement with that obtained from experimental culture. This paper can provide a new idea for the cultivation and preparation of AP large crystals, and promote the application of AP crystals in energetic materials. METHODS: The crystal morphologies of AP in vacuum and H2O solvent under Dreiding force field were predicted based on attachment energy model by using molecular dynamics method in Materials Studio 2019 software. The entire molecular dynamics simulation was carried out under the NTV system, the temperature control method was selected as Anderson, and the system temperature was set to 298 K. The simulation time was set to 40 ps, the step size was set to 1 fs, and the data were outputted every 5000 steps.
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BACKGROUND: More than 83% of the world's population lives under light-polluted skies while information about health effects of outdoor light at night (LAN) is limited. We examined the association of LAN with natural cause (NC) and cardiovascular disease (CVD) mortality using the UK Biobank. METHODS: We included 273 335 participants recruited between 2006 and 2010. Level of LAN was estimated at each participant's address using time-varying satellite data for a composite of persistent night-time illumination at ~1 km2 scale. Information on causes of death until 12 November 2021 was obtained through record linkage. Cox proportional hazards regression was used. RESULTS: In the follow-up with an average of 12.4 years, 14 864 NC and 3100 CVD deaths were identified. Compared with the participants exposed to the first quartile of LAN, participants exposed to the highest quartile showed an 8% higher risk of NC mortality (HR: 1.08, 95% CI 1.03 to 1.13) after adjusting for age, sex, social-economic status, shift work, lifestyle factors and body mass index. However, the association disappeared after further adjustment for PM2.5 and evening noise, with HRs (95% CIs) of 1.02 (0.97 to 1.07), 1.01 (0.97 to 1.06) and 1.03 (0.97 to 1.08), respectively, for the participants exposed to the second, third and fourth quartiles of LAN. No significant associations were observed between LAN and CVD mortality, either. CONCLUSIONS: We did not observe significant associations of LAN with NC and CVD mortality in this large nationwide cohort. The health effects of LAN remain unclear. Further studies are warranted to address this public health concern.
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Background: Studies have highlighted the impacts of temperature variability (TV) on mortality from respiratory diseases and cardiovascular diseases, with inconsistent results specifically in subtropical urban areas than temperate ones. We aimed to fully determine TV-associated health risks over a spectrum of diseases and various subgroups in a subtropical setting. Methods: Using inpatient data from all public hospitals in Hong Kong from 1999 to 2019, we examined the TV-hospitalisation associations by causes, ages, and seasons by fitting a quasi-Poisson regression. We presented the results as estimated percentage changes of hospitalisations per interquartile range (IQR) of TV. Results: TVs in exposure days from 0-5 days (TV0-5) to 0-7 days (TV0-7) had detrimental effects on hospitalisation risks in Hong Kong. The overall population was significantly affected over TV0-5 to TV0-7 in endocrine, nutritional and metabolic (from 0.53% to 0.58%), respiratory system (from 0.38% to 0.53%), and circulatory systems diseases (from 0.47% to 0.56%). While we found no association with seasonal disparities, we did observe notable disparities by age, highlighting older adults' vulnerability to TVs. For example, people aged ≥65 years experienced the highest change of 0.88% (95% CI = 0.34%, 1.41%) in hospitalizations for injury and poisoning per IQR increase in TV0-4. Conclusions: Our population-based study highlighted that TV-related health burden, usually regarded as minimal compared to other environmental factors, should receive more attention and be addressed in future relevant health policies, especially for vulnerable populations during the cold seasons.
Subject(s)
Cardiovascular Diseases , Respiration Disorders , Respiratory Tract Diseases , Humans , Aged , Hong Kong/epidemiology , Temperature , Hospitalization , Respiratory Tract Diseases/epidemiology , SeasonsABSTRACT
BACKGROUND: Heatwaves have significant adverse effects on human health. The frequency, duration, and intensity of heatwaves are projected to increase dramatically, in the context of global warming. However, there are few comprehensive assessments of the health impact of heatwaves considering different definitions, and their characteristics under climate change scenarios. OBJECTIVE: We aimed to compare future excess mortality related to heatwaves among different definitions under climate change, population, and adaptation scenarios in China and further explore the mortality burden associated with heatwave characteristics. METHODS: Daily data during 2010-2019 were collected in Guangzhou, China. We adopted nine common heatwave definitions and applied quasi-Poisson models to estimate the effects of heatwaves and their characteristics' impact on mortality. We then projected the excess mortality associated with heatwaves and their characteristics concerning climate change, population, and adaptation scenarios. RESULTS: The relative risks of the nine common heatwave definitions ranged from 1.05 (95% CI: 1.01, 1.10) to 1.24 (95% CI: 1.13, 1.35). Heatwave-related excess mortality will consistently increase in the future decades considering multiple heatwave definitions, with more rapidly increasing rates under the Shared Socioeconomic Path5-8.5 and non-adaptability scenarios. Regarding heatwave characteristics, the intensity is the main factor involved in the threat of heatwaves. The increasing trend of characteristic-related mortality burden is similar to that of heatwaves, and the mortality burden caused by the duration of the heatwaves was the largest among all characteristics. CONCLUSIONS: This study provides a comprehensive picture of the impact of heatwaves and their characteristics on public health under various climate change scenarios, population changes, and adaptive assumptions. The results may provide important public health implications for policymakers in planning climate change adaptation and mitigation policies, and implementing specific plans.
Subject(s)
Climate Change , Global Warming , Humans , Risk , Infrared Rays , China/epidemiology , Hot Temperature , MortalityABSTRACT
Background: T cell exhaustion (TEX) is an important immune escape mechanism, and an in-depth understanding of it can help improve cancer immunotherapy. However, the prognostic role of TEX in malignant lung adenocarcinoma (LUAD) remains unclear. Methods: Through TCGA and GEO datasets, we enrolled a total of 498 LUAD patients. The patients in TCGA-LUAD were unsupervised clustered into four clusters according to TEX signaling pathway. WGCNA analysis, survival random forest analysis and lasso regression analysis were used to select five differentially expressed genes among different clusters to construct a TEX risk model. The risk model was subsequently validated with GEO31210. By analyzing signaling pathways, immune cells and immune checkpoints using GSEA, GSVA and Cibersortx, the relationship between TEX risk score and these variables was evaluated. In addition, we further analyzed the expression of CCL20 at the level of single-cell RNA-seq and verified it in cell experiments. Results: According to TEX signaling pathway, people with better prognosis can be distinguished. The risk model constructed by CD109, CCL20, DKK1, TNS4, and TRIM29 genes could further accurately identify the population with poor prognosis. Subsequently, it was found that dendritic cells, CD44 and risk score were closely related. The final single-cell sequencing suggested that CCL2O is a potential therapeutic target of TEX, and the interaction between TEX and CD8 + T is closely related. Conclusion: The classification of T cell depletion plays a crucial role in the clinical decision-making of lung adenocarcinoma and needs to be further deepened.
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Despite increasing concerns about the detrimental effects of air pollution on respiratory health, limited evidence is available on these effects in the Hong Kong population, especially in children. In this prospective cohort study between 2012 and 2017, we aimed to investigate the associations between exposure to air pollution (concentrations of fine particulate matter [PM2.5] and nitrogen dioxide [NO2]) and respiratory health (lung function parameters and respiratory diseases and symptoms) in schoolchildren. We recruited 5612 schoolchildren aged 6-16 years in Hong Kong. We estimated the annual average concentrations of ambient PM2.5 and NO2 at each participant's address using spatiotemporal models. We conducted spirometry tests on all participants to measure their lung function parameters and used a self-administered questionnaire to collect information on their respiratory diseases and symptoms and a wide range of covariates. Linear mixed models were used to investigate the associations between exposure to air pollution and lung function. Mixed-effects logistic regression models with random effects were used to investigate the associations of exposure to air pollution with respiratory diseases and symptoms. In all of the participants, every 5-µg/m3 increase in the ambient PM2.5 concentration was associated with changes of - 13.90 ml (95 % confidence interval [CI]: -23.65 ml, -4.10 ml), - 4.20 ml (-15.60 ml, 7.15 ml), 27.20 ml/s (-3.95 ml/s, 58.35 ml/s), and - 19.80 ml/s (-38.35 ml/s, -1.25 ml/s) in forced expiratory volume in 1 s, forced vital capacity, peak expiratory flow, and maximal mid-expiratory flow, respectively. The corresponding lung function estimates for every 5-µg/m3 increase in the ambient NO2 concentration were - 2.70 ml (-6.05 ml, 0.60 ml), - 1.40 ml (-5.40 ml, 2.60 ml), - 6.60 ml/s (-19.75 ml/s, 6.55 ml/s), and - 3.05 ml/s (-11.10 ml/s, 5.00 ml/s), respectively. We did not observe significant associations between PM2.5/NO2 exposure and most respiratory diseases and symptoms. Stratified analyses by sex and age showed that the associations between exposure to air pollution and lung function parameters were stronger in male participants and older participants (11-14 year old group) than in female participants and younger participants (6-10 year old group), respectively. Our results suggest that chronic exposure to air pollution is detrimental to the respiratory health of schoolchildren, especially that of older boys. Our findings reinforce the importance of air pollution mitigation to protect schoolchildren's respiratory health.
Subject(s)
Air Pollutants , Air Pollution , Respiratory Tract Diseases , Humans , Male , Female , Child , Adolescent , Nitrogen Dioxide/analysis , Hong Kong/epidemiology , Prospective Studies , Particulate Matter/toxicity , Particulate Matter/analysis , Air Pollution/adverse effects , Air Pollution/analysis , Respiratory Tract Diseases/epidemiology , Environmental Exposure/analysis , Air Pollutants/toxicity , Air Pollutants/analysisABSTRACT
BACKGROUND: To investigate the associations between long-term exposure to ambient air pollution and age at menopause and the risk of early menopause in two Asian cohorts. METHODS: A total of 53,167 female adults were enrolled from two ongoing cohorts, one each in Taiwan and Hong Kong, between 2003 and 2018, yielding 200,000 person-years of follow-up. We performed a Cox regression model with time-dependent covariates to investigate associations between air pollution and menopause. RESULTS: The mean age at baseline and at natural menopause was 34.4 and 51.0 years, respectively. In the single-pollutant models, we found that increase in PM2.5 and NO2 was associated a younger age at menopause [hazard ratios (HRs) (95% confidence interval, CI): 1.16 (1.09-1.23) and 1.04 (1.01-1.06), respectively, for each 10 µg/m3 increase in air pollution]. In the multiple-pollutant models, the NO2-menopause associations were attenuated after adjusting for PM2.5 and O3, whereas the associations of menopause with PM2.5 and O3 remained stable. Similar associations were observed for the risk of early menopause (age at menopause ≤ 45 years). CONCLUSIONS: Long-term exposure to ambient air pollution was associated with the age at menopause and the risk of early menopause. More effective strategies to mitigate air pollution are required.
Subject(s)
Air Pollutants , Air Pollution , Adult , Female , Humans , Middle Aged , Air Pollutants/adverse effects , Air Pollutants/analysis , Nitrogen Dioxide/adverse effects , Nitrogen Dioxide/analysis , Longitudinal Studies , Air Pollution/adverse effects , Air Pollution/analysis , Cohort Studies , Menopause , Particulate Matter/adverse effects , Particulate Matter/analysis , Environmental Exposure/adverse effects , Environmental Exposure/analysisABSTRACT
OBJECTIVE: Ambient particulate pollution, especially PM2.5, has adverse impacts on health and welfare. To manage and control PM2.5 pollution, it is of great importance to determine the factors that affect PM2.5 levels. Previous studies commonly focused on a single or several cities. This study aims to analyze the impacts of meteorological and socio-economic factors on daily concentrations of PM2.5 in 109 Chinese cities from January 1, 2015 to December 31, 2015. METHODS: To evaluate potential risk factors associated with the spatial and temporal variations in PM2.5 levels, we developed a Bayesian spatio-temporal model in which the potential temporal autocorrelation and spatial autocorrelation of PM2.5 levels were taken into account to ensure the independence of the error term of the model and hence the robustness of the estimated parameters. RESULTS: Daily concentrations of PM2.5 peaked in winter and troughed in summer. The annual average concentration reached its highest value (79⯵g/m3) in the Beijing-Tianjin-Hebei area. The city-level PM2.5 was positively associated with the proportion of the secondary industry, the total consumption of liquefied petroleum gas and the total emissions of industrial sulfur dioxide (SO2), but negatively associated with the proportion of the primary industry. A reverse U-shaped relationship between population density and PM2.5 was found. The city-level and daily-level of weather conditions within a city were both associated with PM2.5. CONCLUSION: PM2.5 levels had significant spatio-temporal variations which were associated with socioeconomic and meteorological factors. Particularly, economic structure was a determinant factor of PM2.5 pollution rather than per capita GDP. This finding will be helpful for the intervention planning of particulate pollution control when considering the environmental and social-economic factors as part of the strategies.
Subject(s)
Air Pollutants/analysis , Air Pollution/statistics & numerical data , Environmental Monitoring , Particulate Matter/analysis , Bayes Theorem , Beijing , Cities , Coal , Dust/analysis , Humans , Meteorological Concepts , Population Density , Seasons , Socioeconomic Factors , Spatial Analysis , WeatherABSTRACT
BACKGROUND: In the context of global warming, most researches have been conducted on health influences of heat waves, with limited understanding of health impacts of cold spells, especially for developing countries. METHODS: We collected daily mortality and meteorological data for 31 capital cities across China during the maximum period of 2007-2013. A quasi-Poisson regression model combined with a distributed lag non-linear model was used to estimate the short-term effects of cold spells on mortality in cold seasons (November to March). 19 definitions of cold spell were clearly compared, including three definitions from the China Meteorological Administration (CMA) and 16 definitions by combining two temperature indicators (daily minimum and mean temperature), two temperature thresholds (3rd and 5th percentile) and four durations of at least 2-5â¯days. Then, a random effect meta-analysis was applied to pool the effect estimates at national level. Furthermore, a stratified analysis was constructed to identify the vulnerable subpopulations to cold spells. RESULTS: The definition, in which daily mean temperature falls below 5th percentile for at least two consecutive days, produced the optimum model fit performance. Generally, the mortality risk increased to the maximum after 3-6â¯days' exposure to cold spell and then leveled off in the next 3â¯weeks. The pooled relative risks (RR) of non-accidental mortality for cold spells were 1.03 (95% CI: 1.01-1.05), 1.27 (1.19-1.35) and 1.55 (1.40-1.70) at lag 0, lag 0-14 and lag 0-27â¯days, respectively. The greatest effect estimates of cold spells were found among total respiratory diseases and COPD, with RR of 1.88 (1.65-2.11) and 1.88 (1.58-2.19), respectively. The elderly, less-educated individuals and residents in southern China were more vulnerable to cold spells. CONCLUSION: There are remarkable mortality effects of cold spells, with effect estimates varying with the definition of cold spell and subpopulations. Using the official definition of cold spells may fail to capture the mortality risk associated with cold spells. These findings may facilitate the development of cold alert warning system and preventive actions to the vulnerable populations.