ABSTRACT
Schizophrenia is a serious mental health illness with unknown etiology, high prevalence, high morbidity and heavy social burden. Some RNAs with regulatory functions may be involved in pathogenesis of many complex diseases, including schizophrenia. miRNAs are non-coding RNAs that negatively regulate gene expression. Differential miRNA expression has been found in the brain and peripheral blood of patients with schizophrenia. miR-195 is an important member of the miR-15/16/195/497 family. Previous studies have implicated that miR-195 may be involved in the pathogenesis of schizophrenia due to its differential expression. This review aimed to clarify the function of miR-195 and summarized the recent researches of miR-195 in schizophrenia.
ABSTRACT
A novel enzymatic hydrogen peroxide sensor was successfully fabricated based on the nanocomposites containing of Ag/C nanocables and gold nanoparticles (AuNPs). Ag/C nanocables have been synthesized by a hydrothermal method and then AuNPs were assembled on the surface of Ag/C nanocables. The nanocomposites were confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometry (EDS). The above nanocomposites have satisfactory chemical stability and excellent biocompatibility. Cyclic voltammetry (CV) was used to evaluate the electrochemical performance of the Ag/C/Au nanocomposites at glassy carbon electrode (GCE). The results indicated that the Ag/C/Au nanocomposites exhibited excellent electrocatalytic activity to the reduction of H(2)O(2). It offered a linear range of 6.7×10(-9) to 8.0×10(-6) M, with a detection limit of 2.2×10(-9) M. The apparent Michaelis-Menten constant of the biosensor was 51.7×10(-6) M. These results indicated that Ag/C/Au nanocomposites have potential for constructing of a variety of electrochemical biosensors.