1.
Chinese Journal of Natural Medicines (English Ed.)
; (6): 540-544, 2021.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-888783
ABSTRACT
A large number of protease inhibitors have been found from leeches, which are essential in various physiological and biological processes. In the curret study, a novel elastase inhibitor was purified and characterized from the leech of Hirudinaria manillensis, which was named HMEI-A. Primary structure analysis showed that HMEI-A belonged to a new family of proteins. HMEI-A exerted inhibitory effects on elastase and showed potent abilities to inhibit elastase with an inhibition constant (K