ABSTRACT
We administered a questionnaire to participants who received different vaccination regimens to evaluate the effectiveness of Ad5-vectored COVID-19 vaccines. The results showed that administration of intramuscular Ad5-nCoV provided 21.32% more protection against SARS-CoV-2 infection than that of the inactivated COVID-19 vaccine in people who had received only one type of COVID-19 vaccine. Furthermore, aerosolized Ad5-nCoV exhibited good protection, whether it was administered as a homologous booster to people vaccinated with the intramuscular Ad5-nCoV or as a heterologous booster to people vaccinated with inactivated COVID-19 vaccines. Our research indicates that Ad5-nCoV is an effective booster. This finding supports the future selection of COVID-19 immunization strategies.
Subject(s)
COVID-19 Vaccines , COVID-19 , SARS-CoV-2 , Vaccines, Inactivated , Humans , COVID-19 Vaccines/administration & dosage , COVID-19 Vaccines/immunology , COVID-19/prevention & control , COVID-19/epidemiology , China/epidemiology , Vaccines, Inactivated/administration & dosage , Vaccines, Inactivated/immunology , SARS-CoV-2/immunology , Retrospective Studies , Male , Adult , Female , Immunization, Secondary , Middle Aged , Surveys and Questionnaires , Vaccination , Aged , Vaccine Efficacy , Aerosols , Young Adult , Antibodies, Viral/blood , Antibodies, Viral/immunologyABSTRACT
To determine distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards in Wuhan, China, we tested air and surface samples. Contamination was greater in intensive care units than general wards. Virus was widely distributed on floors, computer mice, trash cans, and sickbed handrails and was detected in air ≈4 m from patients.