Subject(s)
Cyclosporine/administration & dosage , Dermatitis, Atopic/diagnosis , Dermatitis, Atopic/therapy , Ultraviolet Therapy/methods , Administration, Oral , Adult , Combined Modality Therapy , Dose-Response Relationship, Drug , Dose-Response Relationship, Radiation , Female , Follow-Up Studies , Humans , Male , Prospective Studies , Severity of Illness Index , Treatment OutcomeABSTRACT
Autologous bone marrow transplantation and autologous peripheral blood stem cell transplantation (APBSCT) are alternative therapeutic options in the treatment of various malignancies. We describe four patients undergoing APBSCT for malignancies; they developed a cutaneous eruption characterized by confluent erythematous and hyperpigmented patches within the flexural areas during the first month after transplantation. The lesions were poorly circumscribed without epidermal changes such as scaling, xerosis, erosions or atrophy. The skin patches were treated with topical corticosteroids and resolved within a few days with discoloration. Histopathological findings were characterized by focal vacuolar degeneration of the basal layer with epidermal dysmaturation. We believe that these cutaneous eruptions are consistent with an interplay of high-dose chemotherapy and local factors such as friction, local skin temperature and eccrine gland distribution, which could explain the constant location of this eruption in the axillae and genital area.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Drug Eruptions/etiology , Erythema/etiology , Hematopoietic Stem Cell Transplantation/adverse effects , Drug Eruptions/pathology , Erythema/pathology , Female , Humans , Male , Middle Aged , Neoplasms/therapyABSTRACT
Reactive cutaneous angioendotheliomatosis (RCA) is an uncommon benign disease characterized by intravascular proliferation of endothelial cells. The observation of RCA in infants is exceedingly rare. We describe a case of RCA in a 3-month-old infant. The lesions were characterized by six small purpuric papules (1-2 mm in diameter), distributed on the thighs and neck. The general condition of the patient was good, with no lymphadenopathy, systemic involvement, or fever. The histopathologic features of a papule were characterized by the presence of cohesive aggregates of large mononucleated cells protruding into the lumina of dilated vessels and filling some of them completely. Neither an inflammatory infiltrate nor a proliferation of pericytes were present around blood vessels. Intravascular proliferating cells demonstrated positive staining for Ulex europaeus agglutinin 1 (UEA-1) and for Factor VIII-RA and CD34 antigens. The course of the disease was unremarkable with persistence of the lesions for 8 months; no treatment was started.
