"Empty" sac in pregnant women with bleeding: are measurements answering the right question?

PURPOSE: To assess the percentage of first-trimester pregnancies with bleeding that demonstrate a visible sac but lack an identifiable embryo and have a mean sac diameter (MSD) in the controversial range of 16-20 mm. METHODS: Retrospective study of all first-trimester sonograms among women with vaginal bleeding during a 4-year interval. RESULTS: The study cohort consisted of 546 first- trimester sonograms. An embryo was not seen in 132 cases (24%). Of these, the MSD in 69 cases (52%) was <16 mm, between 16 and 19 mm in 20 cases (15%), or >or=20 mm in 39 cases (30%). The percentage of women who were threatening to abort who demonstrated a visible sac but lacked an identifiable embryo and had a MSD in the controversial range of 16-20 mm was 3.7% (20/546). CONCLUSION: We found that of 546 sonograms undertaken in pregnant women with vaginal bleeding in the first trimester, only 20 patients (3.7%) fell in the MSD range of 16-20 mm. Therefore, even among those diagnosticians who adopt the most stringent criterion (MSD = 20 mm), an additional examination would be requested in fewer than 1 in 25 patients.

Second trimester prenatal ultrasound for the detection of pregnancies at increased risk of Trisomy 18 based on serum screening.

OBJECTIVE: To describe ultrasound findings in fetuses with Trisomy 18. METHODS: Prospective population-based cohort study of second trimester ultrasound among Californian women who were at increased risk of chromosome abnormality based on serum screening between November 1999 and April 2001. Structural anomalies plus the following soft markers were assessed: nuchal fold thickening, choroid plexus cyst (CPC), echogenic intracardiac focus, echogenic bowel, renal pyelectasis, clenched hands; clinodactyly; short femur, short humerus and a single umbilical artery (SUA). RESULTS: Overall, 8763 women underwent ultrasound evaluation, including 56 whose fetuses had Trisomy 18. Ultrasound anomalies were seen in 89% of Trisomy 18 fetuses, as compared with 14% of normal fetuses. If the genetic sonogram was normal (no structural anomaly and no soft marker), the risk was reduced by approximately 90%. The ultrasound soft markers were typically seen in conjunction with structural anomalies in affected fetuses and in the absence of a structural anomaly, most isolated ultrasound soft markers were not associated with Trisomy 18. The only exception was an isolated CPC, seen as the only finding in 11% of fetuses with Trisomy 18. CONCLUSIONS: If the genetic sonogram is used as a sequential test following serum biochemistry, a normal ultrasound study reduces the likelihood of Trisomy 18 substantially even if a woman has abnormal serum biochemistry. The presence of an isolated CPC raises the risk, but not high enough to prompt invasive testing.

Five-millimeter and smaller embryos without embryonic cardiac activity: outcomes in women with vaginal bleeding.

OBJECTIVE: The purpose of this study was to assess outcomes in embryos with a crown-rump length (CRL) of 5 mm or less without embryonic cardiac activity (ECA) among pregnant women with vaginal bleeding in the first trimester. METHODS: A retrospective study of all first-trimester sonograms in women with vaginal bleeding from 1999 to 2002 was conducted. RESULTS: Thirty-seven embryos without detectable ECA that had a CRL of 5 mm or less were identified. All resulted in pregnancy failure. The breakdown of these embryos by CRL was as follows: 13 were 5 mm; 10 ranged from 4 to 4.9 mm; 11 ranged from 3 to 3.9 mm; and 3 ranged from 2 to 2.9 mm. CONCLUSIONS: In pregnant women with vaginal bleeding, embryos of 5 mm and smaller without a heartbeat all resulted in pregnancy failure.