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1.
Front Med (Lausanne) ; 10: 1242260, 2023.
Article in English | MEDLINE | ID: mdl-37964885

ABSTRACT

Introduction: Randomized controlled trials have demonstrated a reduction in the decline of lung function and a reduced risk of acute exacerbation in patients with idiopathic pulmonary fibrosis treated with the antifibrotic prifenidone. The present study aimed to investigate the real-world effectiveness and safety profile of pirfenidone treatment for patients with IPF in Taiwan. Methods: Between January 1, 2019 and December 31, 2020, we enrolled 50 patients who were newly diagnosed with IPF and had at least 12 months follow-up period after pirfenidone administration. Result: The primary outcome of pharmacologic effect showed that the mean differences in the absolute values of forced vital capacity from baseline were 0.2 liter (n = 36), 0.13 liter (n = 32), 0.04 liter (n = 26), and - 0.004 liter (n = 26) after 3, 6, 9, and 12 months of administration, respectively. A slight improvement in quality of life, including scores of chronic obstructive pulmonary disease assessment test and St. George's respiratory questionnaire scores. The most common adverse effects were gastrointestinal upset and dermatological problems. No new safety concerns were observed in the present study. Conclusion: Our real-world study describe for the first time in Taiwan, the use of pirfenidone over a 12 months period. This drug preserves the lung function and improves quality of life with tolerable side effects.

2.
Environ Sci Pollut Res Int ; 30(48): 106068-106082, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37726623

ABSTRACT

A unique triple perovskite-type catalyst was successfully synthesized using the simple sol-gel approach, and surface acid modification was added to improve the ozone catalytic oxidation (OZCO) process ability to remove toluene more effectively. Our study indicates that La3MnCuNiO9 catalyst treated with KMnO4 shows the best toluene oxidation activity. At 250 °C, the rates of conversion and mineralization were 100% and 83%, respectively, under thermal catalytic system when C7H8 concentration = 500 ppm. During the OZCO system ([C7H8] = 20 ppm, O3/C7H8=8; room temperature), for 6 h, the conversion rate remained at 100%. The high ratios of Mn4+/(Mn4++Mn3+), Cu2+, and abundant surface oxygen species, high specific surface area, and pore volume lead to remarkable catalytic performance of this catalyst. Meanwhile, the catalyst contributes to superior stability and water resistance. The catalytic mechanism of La3MnCuNiO9 after KMnO4 treatment in the context of OZCO was further discussed. Overall, after KMnO4 treatment, the La3MnCuNiO9 catalyst reveals extraordinary catalytic activity and excellent stability combination of this catalyst with ozone exhibits high toluene removal efficiency in the OZCO system and has a good potential for industrial applications.


Subject(s)
Ozone , Toluene , Oxides , Oxidation-Reduction , Catalysis
3.
Environ Sci Pollut Res Int ; 30(12): 32696-32709, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36469276

ABSTRACT

Manganese oxide-based catalysts have attracted extensive attention due to their relatively low cost and remarkable performance for removing VOCs. In this research, we used the Pechini method to synthesize manganese-cerium-nickel ternary oxide catalysts (MCN) and evaluated the effectiveness of catalytic destruction of formaldehyde (HCHO) and ozone at room temperature. FeOx prepared by the impregnation method was applied to modify the catalyst. After FeOx treatment, the catalyst represented the best performance on both HCHO destruction and ozone decomposition under dry conditions and exhibited excellent water vapor resistance. The as-prepared catalysts were next characterized via H2-temperature programmed reduction (H2-TPR), temperature programmed desorption of O2 (O2-TPD), and X-ray photoelectron spectroscopy (XPS), and the results demonstrated that addition of FeOx increased Mn3+ and Ce3+ concentrations, oxygen vacancies and surface lattice oxygen species, facilitated adsorption, and redox properties. Based on the results of in situ diffuse reflectance infrared Fourier transform spectrometry (DRIFTS), possible mechanisms of ozone catalytic oxidation of HCHO were proposed. Overall, the ternary mixed-oxide catalyst developed in this study holds great promise for HCHO and ozone decomposition in the indoor environment.


Subject(s)
Ozone , Ozone/chemistry , Oxidation-Reduction , Oxides/chemistry , Oxygen , Catalysis , Formaldehyde/chemistry
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