1.
Org Lett
; 11(19): 4438-40, 2009 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-19719157
ABSTRACT
The first synthesis of carbon-stapled beta(3)-peptides is reported. The precursor beta(3)-peptides, with O-allyl beta-serines located in an i/i+3 relationship, were prepared on solid phase. We show that efficient ring-closing metathesis (RCM) of these new beta(3)-peptides proceeds smoothly either in solution or on an appropriate solid support. All products were generated with high selectivity for the E-isomer.