Subject(s)
Lymphedema/pathology , Adult , Female , Foot , Humans , Hypothyroidism/complications , Lymphedema/etiologyABSTRACT
A 12-year-old Scottish terrier had a scrotal mass which was diagnosed as a malignant mesothelioma of the tunica vaginalis. The tumour resulted in a rapidly fatal clinical course with direct extension into the peritoneal cavity via the inguinal canal; there were no haematogenous or lymphatic metastases. This is the first case report of such a tumour in the dog. The histology and differential diagnoses of these tumours and a review of similar tumours in other species and possible causative agents are given.
Subject(s)
Dog Diseases/pathology , Mesothelioma/veterinary , Testicular Neoplasms/veterinary , Animals , Dogs , Male , Mesothelioma/pathology , Testicular Neoplasms/pathologyABSTRACT
A rare instance of renal cell carcinoma metastatic to the prostate gland is described. The prostatic metastases caused acute urinary retention and were clinically thought to represent benign prostatic hypertrophy. Histologic examination of the transurethral resection specimen demonstrated the true nature of the tumor.
Subject(s)
Adenocarcinoma/secondary , Kidney Neoplasms , Prostatic Neoplasms/secondary , Adenocarcinoma/pathology , Aged , Humans , Kidney Neoplasms/pathology , Male , Prostatic Hyperplasia/surgery , Prostatic Neoplasms/pathologyABSTRACT
Malignant neoplasms of the mucosa and minor salivary glands of the paranasal sinuses may involve the skin by direct extension. When a tumor appears on the overlying skin, these sinuses should be considered as a possible site of origin. Adenoid cystic carcinoma of the paranasal sinuses arise from minor salivary glands. They can infiltrate overlying skin and easily be confused with a primary cutaneous adenoid cystic carcinoma. Malignant melanomas of the paranasal sinuses are clinically very aggressive. They are often amelanotic, and this may lead to an incorrect histopathologic diagnosis. Hence, physical and radiological examination of the nose, mouth, and paranasal sinuses should be performed whenever a tumor appears in the overlying skin that does not have a clear cutaneous origin or whenever the primary site of a metastatic malignant melanoma is unknown.
Subject(s)
Carcinoma, Adenoid Cystic/pathology , Melanoma/pathology , Paranasal Sinus Neoplasms/pathology , Skin Neoplasms/pathology , Aged , Ethmoid Sinus/pathology , Female , Frontal Sinus/pathology , Humans , Male , Maxillary Sinus/pathology , Neoplasm MetastasisABSTRACT
A woman in whom the use of dextrothyroxine was associated with clinical hyperthyroidism is described. She had a markedly elevated T3 level while receiving the drug, apparently resulting from conversion of the dextrothyroxine to triiodothyronine. The T3 levels fell to normal after withdrawal. Patients receiving dextrothyroxine should be examined for possible elevation of T4 and T3 thyrotoxicosis.
Subject(s)
Dextrothyroxine/blood , Hyperthyroidism/etiology , Triiodothyronine/blood , Aged , Dextrothyroxine/adverse effects , Dextrothyroxine/metabolism , Female , Humans , Hyperthyroidism/chemically induced , Iatrogenic Disease , Triiodothyronine/metabolismABSTRACT
The apparent effect of ionizing radiation on lung cancer in A-bomb survivors has not been large enough to still doubts as to its validity. It has seemed essential to determine whether the apparent radiation effect could have resulted from a confounding of heavy smoking and high radiation dose, or if the occupational exposure of high-dose subjects with lung cancer was suggestive of the influence of environmental hazards other than radiation. The available series consists of 204 subjects with lung cancer verified by autopsy, 61 of whom were low-dose (less than 1 rad) and 13 high-dose (200 + rads) subjects. No evidence could be found that the influence of either smoking or occupational exposure upon lung cancer was exerted so as to suggest that the apparent radiation effect is other than real. The study also provides additional evidence of the relationship between lung cancer and smoking in Japanese.
Subject(s)
Lung Neoplasms/etiology , Occupational Diseases/complications , Radioactive Fallout , Smoking/complications , Aged , Autopsy , Female , Humans , Japan , Male , Middle Aged , Nuclear Warfare , Radiation Dosage , Radiation Injuries/complications , RiskABSTRACT
A reappraisal was made of the relationship between exposure to atomic radiation in 1945 and the occurrence of salivary gland tumors in heavily exposed survivors. This was made possible by the discovery of 8 additional patients; the total now reported consists of 30 cases. In those exposed to 300+ rads, the number of cases was significantly (p less than .01) greater than expected. This was found for the combined group and for malignant types, but not for histologically benign tumors. Our prior conclusion regarding the high-dose radiation effect upon salivary gland neoplasia remains unchanged in the reanalysis; however, our suggestion that younger persons were at significantly greater risk is weakened.