Subject(s)
Phototherapy/methods , Skin Pigmentation , Vitiligo/radiotherapy , Adult , Erythema/etiology , Female , Humans , Male , Middle Aged , Patient Satisfaction , Phototherapy/adverse effects , Prospective Studies , Young AdultSubject(s)
Facial Neoplasms/pathology , Sarcoma, Myeloid/pathology , Skin Neoplasms/pathology , Aged , Female , HumansSubject(s)
Esophageal Neoplasms/pathology , Granular Cell Tumor/pathology , Skin Neoplasms/pathology , Adult , Elbow , Female , Hand , Humans , LipSubject(s)
Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Formaldehyde/adverse effects , Hand Dermatoses/chemically induced , Occupational Exposure/adverse effects , Resins, Plant/adverse effects , Textiles , Adult , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Hand Dermatoses/diagnosis , Humans , Male , Patch TestsSubject(s)
Allergens/adverse effects , Dental Technicians , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Occupational Exposure/adverse effects , Resins, Plant/adverse effects , Adult , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Humans , Male , Patch TestsABSTRACT
17 patients with angry back syndrome were identified over a 4-year period (1994-97). 10 such patients were classified as multiple reactors and 7 as exacerbations of atopic eczema. The 10 multiple reactors reacted most commonly to medicaments, rubber chemicals, fragrances, methylchloroisothiazolinone/methylisothiazolinone, colophonium and nickel. A final diagnosis of relevant allergic contact dermatitis was made in 8 of the 10 patients with multiple reactions. Relevant contact allergens were rubber chemicals, plants, metals and preservatives, all of which can be marginal irritants. None of the reactions in the patients with exacerbation of dermatitis were thought to be relevant or helpful in the further management of the patient. Reactions in the angry back syndrome appear to be due most commonly to marginal irritants. In multiple reactors, marginal irritants were also the most common allergens finally identified.
Subject(s)
Dermatitis, Allergic Contact/diagnosis , Hypersensitivity, Delayed/diagnosis , Irritants , Dermatitis, Allergic Contact/immunology , Diagnosis, Differential , Eczema/diagnosis , False Positive Reactions , Female , Humans , Hypersensitivity, Delayed/immunology , Male , Patch Tests/methods , Retrospective Studies , Sensitivity and Specificity , Severity of Illness IndexABSTRACT
A 61-year-old woman, who was known to have Hailey-Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This may be another example of chronic inflammation of the vulval area leading to the development of squamous cell carcinoma. However, in this case, chronic human papillomavirus may also have played a part, leading to VIN and reactivation of the Hailey-Hailey disease. We can find no previous reports of squamous cell carcinoma developing in the setting of Hailey-Hailey disease.
Subject(s)
Carcinoma in Situ/etiology , Carcinoma, Squamous Cell/etiology , Pemphigus, Benign Familial/complications , Vulvar Diseases/complications , Vulvar Neoplasms/etiology , Female , Humans , Middle Aged , Papillomaviridae , Papillomavirus Infections/complications , Tumor Virus Infections/complicationsABSTRACT
Paraffin-based emollients are widely used in dermatological practice and are not usually absorbed through the skin. We report a case where transcutaneous transfer did occur in the context of damaged skin in Netherton's syndrome, resulting in a reversible lymphadenopathy.
Subject(s)
Emollients/adverse effects , Granuloma, Foreign-Body/etiology , Ichthyosiform Erythroderma, Congenital/pathology , Lymph Nodes/pathology , Adolescent , Emollients/therapeutic use , Granuloma, Foreign-Body/pathology , Humans , Ichthyosiform Erythroderma, Congenital/therapy , Skin AbsorptionSubject(s)
Dermatitis, Exfoliative/chemically induced , Drug Eruptions , Enzyme Inhibitors/adverse effects , Omeprazole/analogs & derivatives , Omeprazole/adverse effects , Proton Pump Inhibitors , 2-Pyridinylmethylsulfinylbenzimidazoles , Aged , Aged, 80 and over , Esophagitis/drug therapy , Female , Humans , Lansoprazole , Male , Middle Aged , Stomach Ulcer/drug therapySubject(s)
Ambulatory Care , Hospitalization , Psoriasis/therapy , Adult , England , Humans , Middle AgedABSTRACT
A 47-year-old man had multiple large congenital melanocytic nevi associated with striking atrophic changes. Biopsy specimens showed a prominent reduction and fragmentation of elastic fibers in the papillary dermis. The anetoderma-like changes may have been secondary to a past inflammatory process but more likely represent a hamartoma.
Subject(s)
Connective Tissue Diseases/pathology , Elastic Tissue/pathology , Hamartoma/pathology , Nevus, Pigmented/congenital , Skin Diseases/pathology , Skin Neoplasms/congenital , Humans , Male , Middle Aged , Nevus, Intradermal/congenital , Nevus, Intradermal/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathologyABSTRACT
An 83-year-old woman presented with a vulval mass. Radical vulvectomy was performed and histology showed a unique mixed picture of spindle, pseudoglandular and classical squamous cell carcinoma arising in vulval lichen sclerosus.
Subject(s)
Carcinoma, Squamous Cell/pathology , Lichen Sclerosus et Atrophicus/complications , Vulvar Neoplasms/pathology , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/etiology , Female , Humans , Vulvar Neoplasms/etiologyABSTRACT
Allergic contact dermatitis from shoes may have a typical pattern of presentation, but we have found that the distribution of dermatitis is often unhelpful in establishing the diagnosis. In this study, we aimed to define the features of foot dermatitis in children and to assess its outcome, in comparison to adults with foot eruptions. Relevant allergens were found in 15 out of 29 children and 26 out of 57 adults with foot eruptions. The most common allergens in children were rubber chemicals and topical medicaments. Adults showed a similar pattern, but also reacted to clothing dyes. The prognosis in both groups was good, with the dermatitis improving or resolving in 2/3.